Coxsackievirus A6 2C protein antagonizes IFN-β production through MDA5 and RIG-I depletion.
2C protein
HFMD
IFN-β
MDA5
RIG-I
coxsackievirus A6
enterovirus
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
30 Nov 2023
30 Nov 2023
Historique:
medline:
1
12
2023
pubmed:
17
10
2023
entrez:
17
10
2023
Statut:
ppublish
Résumé
Coxsackievirus A6 (CV-A6) is a major emerging pathogen associated with atypical hand, foot, and mouth disease and can cause serious complications such as encephalitis, acute flaccid paralysis, and neurorespiratory syndrome. Therefore, revealing the associated pathogenic mechanisms could benefit the control of CV-A6 infections. In this study, we demonstrate that the nonstructural 2C
Identifiants
pubmed: 37847581
doi: 10.1128/jvi.01075-23
pmc: PMC10688345
doi:
Substances chimiques
2C protein, viral
EC 3.6.1.-
Interferon-beta
77238-31-4
IFIH1 protein, human
EC 3.6.1.-
RIGI protein, human
EC 3.6.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0107523Subventions
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 81902049
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 32170146
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 32170140
Organisme : The Science and Technology Department of Jilin Province
ID : 20200201525JC
Organisme : The Science and Technology Department of Jilin Province
ID : 20220101285JC
Organisme : The Science and Technology Department of Jilin Province
ID : 20210101314JC
Organisme : The Science and Technology Department of Jilin Province
ID : 20220101301JC
Organisme : The Fundamental Research Funds for the Central Universities
ID : 2017TD-08
Organisme : The Key Laboratory of Molecular Virology, Jilin Province
ID : 20102209
Organisme : The First Hospital of Jilin University
ID : 2020-CXQ-02
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Virol. 2014 Aug;88(16):8936-45
pubmed: 24872591
PLoS One. 2012;7(3):e32405
pubmed: 22479324
J Virol. 2017 Jun 9;91(13):
pubmed: 28424289
J Virol. 2010 Aug;84(16):8051-61
pubmed: 20519382
Immunol Rev. 2007 Dec;220:214-24
pubmed: 17979849
Mob DNA. 2022 Apr 12;13(1):10
pubmed: 35414110
Curr Opin Immunol. 2008 Feb;20(1):17-22
pubmed: 18272355
Emerg Microbes Infect. 2015 Feb;4(2):e12
pubmed: 26038764
Antiviral Res. 2011 Mar;89(3):204-18
pubmed: 21236302
J Virol. 2003 Jul;77(14):7903-13
pubmed: 12829830
J Virol. 1997 Dec;71(12):8962-72
pubmed: 9371552
J Virol. 2021 Feb 24;95(6):
pubmed: 33328314
Nature. 2011 Apr 28;472(7344):481-5
pubmed: 21478870
Sci Adv. 2017 Apr 28;3(4):e1602573
pubmed: 28508043
J Virol. 2008 Jan;82(1):335-45
pubmed: 17942531
Immunity. 2008 Oct 17;29(4):538-50
pubmed: 18818105
Microb Pathog. 2016 Nov;100:84-89
pubmed: 27633794
PLoS Pathog. 2015 Jul 28;11(7):e1005067
pubmed: 26218680
Springerplus. 2016 Sep 23;5(1):1650
pubmed: 27733967
J Virol. 2018 May 14;92(11):
pubmed: 29563294
J Biol Chem. 2007 Feb 23;282(8):5888-98
pubmed: 17182608
J Med Virol. 2015 Sep;87(9):1471-9
pubmed: 25951788
J Biol Chem. 2009 Dec 11;284(50):35060-72
pubmed: 19837671
J Virol Methods. 2013 Feb;187(2):362-7
pubmed: 23178532
mBio. 2021 Oct 26;12(5):e0231621
pubmed: 34488448
J Virol. 2007 Jan;81(2):514-24
pubmed: 17079289
J Infect. 2014 Sep;69(3):303-5
pubmed: 24704297
Lancet Infect Dis. 2010 Nov;10(11):778-90
pubmed: 20961813
J Biomed Sci. 2019 Dec 2;26(1):95
pubmed: 31787104
J Virol. 1988 Nov;62(11):4016-21
pubmed: 2845120
J Gen Virol. 2014 Jun;95(Pt 6):1255-1265
pubmed: 24558221
Virology. 1994 Jul;202(1):129-45
pubmed: 8009827
Cell Death Differ. 2005 Nov;12 Suppl 2:1542-52
pubmed: 16247502
J Virol. 2004 Sep;78(17):9243-56
pubmed: 15308719
J Virol. 2016 Apr 29;90(10):5141-5151
pubmed: 26962213
J Virol. 1997 Nov;71(11):8759-65
pubmed: 9343235
Emerg Infect Dis. 2021 Sep;27(9):2261-2268
pubmed: 34423767
Nat Genet. 2014 May;46(5):503-509
pubmed: 24686847
Virology. 2018 May;518:328-334
pubmed: 29587191
Cleve Clin J Med. 2014 Sep;81(9):537-43
pubmed: 25183845
J Med Virol. 2017 Dec;89(12):2116-2121
pubmed: 28771766
J Virol. 2003 Jan;77(2):891-904
pubmed: 12502805
Antiviral Res. 2000 Oct;48(1):61-9
pubmed: 11080541
PLoS Pathog. 2010 Aug 26;6(8):e1001066
pubmed: 20865167
J Biol Chem. 1999 Mar 12;274(11):6992-7001
pubmed: 10066753
Immunol Rev. 2009 Jan;227(1):75-86
pubmed: 19120477
J Virol. 2012 Sep;86(18):9964-75
pubmed: 22761387
Sci Rep. 2015 Jun 30;5:11700
pubmed: 26121916
Viral Immunol. 2021 May;34(4):218-226
pubmed: 33226912
Nucleic Acids Res. 1989 Nov 11;17(21):8413-40
pubmed: 2555771
J Autoimmun. 2018 Jun;90:105-115
pubmed: 29525183
Nat Immunol. 2004 Jul;5(7):730-7
pubmed: 15208624
J Virol. 2014 Mar;88(6):3369-78
pubmed: 24390337
Biochem Biophys Res Commun. 1995 Jan 5;206(1):64-76
pubmed: 7818552
Annu Rev Biochem. 2017 Jun 20;86:193-224
pubmed: 28460188
J Virol. 2019 May 1;93(10):
pubmed: 30814289
J Immunol. 2011 Sep 1;187(5):2202-12
pubmed: 21810613
J Virol. 2000 Oct;74(19):8953-65
pubmed: 10982339
FEMS Microbiol Rev. 2002 Mar;26(1):91-107
pubmed: 12007645
PLoS Pathog. 2020 Sep 30;16(9):e1008927
pubmed: 32997711
Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):
pubmed: 34930823
Front Microbiol. 2022 Jan 06;12:811553
pubmed: 35069515
Virology. 1994 Feb 15;199(1):176-87
pubmed: 8116241
J Virol. 2000 Nov;74(22):10371-80
pubmed: 11044081
J Biol Chem. 1993 Apr 15;268(11):8105-10
pubmed: 8385138
Immunity. 2011 May 27;34(5):680-92
pubmed: 21616437
PLoS One. 2013 May 01;8(5):e63431
pubmed: 23650567
Nucleic Acids Res. 2018 Nov 30;46(21):11514-11527
pubmed: 30247716
Nat Immunol. 2006 Feb;7(2):131-7
pubmed: 16424890
Mol Cell Biol. 1998 May;18(5):2986-96
pubmed: 9566918
Sci Rep. 2016 Feb 17;6:21888
pubmed: 26883855
Gut Pathog. 2022 Mar 21;14(1):12
pubmed: 35313977
J Immunol. 2013 Jul 15;191(2):660-9
pubmed: 23772026
Sci Rep. 2016 Feb 10;6:20839
pubmed: 26861413
Front Microbiol. 2020 Dec 14;11:615965
pubmed: 33381104