BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.

Mice Humans Animals Mucociliary Clearance / physiology Respiratory System / metabolism Mucus / metabolism Lung Diseases / metabolism Mice, Knockout
mucin mucociliary clearance mucus rheology viscoelasticity

Journal

American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229

Informations de publication

Date de publication:
01 12 2023
Historique:
medline: 6 12 2023
pubmed: 17 10 2023
entrez: 17 10 2023
Statut: ppublish

Résumé

Airway mucociliary clearance (MCC) is required for host defense and is often diminished in chronic lung diseases. Effective clearance depends upon coordinated actions of the airway epithelium and a mobile mucus layer. Dysregulation of the primary secreted airway mucin proteins, MUC5B and MUC5AC, is associated with a reduction in the rate of MCC; however, how other secreted proteins impact the integrity of the mucus layer and MCC remains unclear. We previously identified the gene

Identifiants

DOI: 10.1152/ajplung.00390.2022 PMID: 37847709
pubmed: 37847709
doi: 10.1152/ajplung.00390.2022
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

L765-L775

Subventions

Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : HL122711
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : F31HL143853
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : 5T32 GM007092
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : R01HL125280
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : P01HL164320
Organisme : Cystic Fibrosis Foundation (CFF)
ID : EHRE20XX0
Organisme : Vertex Pharmaceuticals
ID : Ehre Research Innovation Award
Organisme : Cystic Fibrosis Foundation (CFF)
ID : HILL20Y2-OUT
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : HL13691
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : HL108808
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : HL15054

Auteurs

Lauren J Donoghue (LJ)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Matthew R Markovetz (MR)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
ORCID: 0000-0003-3931-0594

Cameron B Morrison (CB)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
ORCID: 0000-0002-4031-9521

Gang Chen (G)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Kathryn M McFadden (KM)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Taraneh Sadritabrizi (T)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Mark I Gutay (MI)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Takafumi Kato (T)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
ORCID: 0000-0003-2248-3376

Troy D Rogers (TD)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Jazmin Y Snead (JY)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Alessandra Livraghi-Butrico (A)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
ORCID: 0000-0001-8751-3631

Brian Button (B)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

Camille Ehre (C)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
ORCID: 0000-0002-0046-0096

Barbara R Grubb (BR)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.

David B Hill (DB)

Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, United States.
ORCID: 0000-0002-9270-777X

Samir N P Kelada (SNP)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
ORCID: 0000-0003-2676-9232

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › BPIFB1 loss alters airway mucus properties and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › BPIFB1 loss alters airway mucus properties and...
questionsmedicales.fr › Eucaryotes › Animaux › BPIFB1 loss alters airway mucus properties and...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Clairance mucociliaire › BPIFB1 loss alters airway mucus properties and...
questionsmedicales.fr › Appareil respiratoire › BPIFB1 loss alters airway mucus properties and...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Mucus › BPIFB1 loss alters airway mucus properties and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › BPIFB1 loss alters airway mucus properties and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › BPIFB1 loss alters airway mucus properties and...