Lysosomes in retinal health and disease.
age-related macular degeneration
glaucoma
lysosome membrane permeabilization
lysosome–mitochondria crosstalk
mTOR signaling
retinitis pigmentosa
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
18
06
2023
revised:
06
09
2023
accepted:
24
09
2023
medline:
24
11
2023
pubmed:
18
10
2023
entrez:
17
10
2023
Statut:
ppublish
Résumé
Lysosomes play crucial roles in various cellular processes - including endocytosis, phagocytosis, and autophagy - which are vital for maintaining retinal health. Moreover, these organelles serve as environmental sensors and act as central hubs for multiple signaling pathways. Through communication with other cellular components, such as mitochondria, lysosomes orchestrate the cytoprotective response essential for preserving cellular homeostasis. This coordination is particularly critical in the retina, given its high metabolic rate and susceptibility to photo-oxidative stress. Consequently, impaired lysosomal function and dysregulated communication between lysosomes and other organelles contribute significantly to the pathobiology of major retinal degenerative diseases. This review explores the pivotal role of lysosomes in retinal cells and their involvement in retinal degenerative diseases.
Identifiants
pubmed: 37848361
pii: S0166-2236(23)00224-2
doi: 10.1016/j.tins.2023.09.006
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1067-1082Subventions
Organisme : NEI NIH HHS
ID : P30 EY008098
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031594
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests D.S. has patents on Cryba1 and TFEB as therapies for eye-related diseases. The other authors declare no competing interests.