Serum sodium improvement: change in Comprehensive Geriatric Assessment parameters in geriatric patients with hyponatremia.
CGA
Comprehensive Geriatric Assessment
Geriatric population
Hyponatremia
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
17 10 2023
17 10 2023
Historique:
received:
26
02
2023
accepted:
08
09
2023
medline:
23
10
2023
pubmed:
18
10
2023
entrez:
17
10
2023
Statut:
epublish
Résumé
Hyponatremia presents with symptoms considered age-associated in the elderly. We assess the change in Comprehensive Geriatric Assessment (CGA) parameters after hyponatremia improvement in hospitalized geriatric patients. We took 100 hyponatremic and same number of eunatremic geriatric patients (> 60 years) who were comorbidity, presenting-complaints, and age-matched. Four CGA parameters were utilized, the new Hindi Mental State Examination (HMSE), Barthel's index of activities of daily living (ADL), Timed up and go Test (TUG), and handgrip strength by hand dynamometer (HG). We analyzed these at admission and discharge, and their relationship with change in sodium levels. Average age was 68.1 ± 5.8 years, with males constituting 75%. The CGA parameters demonstrated worse values amongst the hyponatremia than the normonatremia group. Severe hyponatremia group showed worse CGA scores in comparison with moderate and mild. With improvement in sodium level, the improvements in ADL, TUG, and HMSE scores were greater in the hyponatremia group (8.8 ± 10.1, 2.2 ± 2.5, and 1.7 ± 2.3 respectively) in comparison to the normonatremia reference group (4.7 ± 9.0, 1 ± 2.0, and 0.7 ± 1.3 respectively, P < 0.05). Our study is the first utilizing HMSE to assess change in cognitive ability with improvement in serum sodium levels in the Indian elderly. Hyponatremic patients show worse baseline CGA parameters, and hyponatremia severity correlates with worse motor and cognitive function. Improvement in the serum sodium level improves the CGA parameters. Correction of hyponatremia in the geriatric age group significantly impacts life quality.
Sections du résumé
BACKGROUND
Hyponatremia presents with symptoms considered age-associated in the elderly. We assess the change in Comprehensive Geriatric Assessment (CGA) parameters after hyponatremia improvement in hospitalized geriatric patients.
METHODS
We took 100 hyponatremic and same number of eunatremic geriatric patients (> 60 years) who were comorbidity, presenting-complaints, and age-matched. Four CGA parameters were utilized, the new Hindi Mental State Examination (HMSE), Barthel's index of activities of daily living (ADL), Timed up and go Test (TUG), and handgrip strength by hand dynamometer (HG). We analyzed these at admission and discharge, and their relationship with change in sodium levels.
RESULTS
Average age was 68.1 ± 5.8 years, with males constituting 75%. The CGA parameters demonstrated worse values amongst the hyponatremia than the normonatremia group. Severe hyponatremia group showed worse CGA scores in comparison with moderate and mild. With improvement in sodium level, the improvements in ADL, TUG, and HMSE scores were greater in the hyponatremia group (8.8 ± 10.1, 2.2 ± 2.5, and 1.7 ± 2.3 respectively) in comparison to the normonatremia reference group (4.7 ± 9.0, 1 ± 2.0, and 0.7 ± 1.3 respectively, P < 0.05).
CONCLUSION
Our study is the first utilizing HMSE to assess change in cognitive ability with improvement in serum sodium levels in the Indian elderly. Hyponatremic patients show worse baseline CGA parameters, and hyponatremia severity correlates with worse motor and cognitive function. Improvement in the serum sodium level improves the CGA parameters. Correction of hyponatremia in the geriatric age group significantly impacts life quality.
Identifiants
pubmed: 37848812
doi: 10.1186/s12877-023-04299-x
pii: 10.1186/s12877-023-04299-x
pmc: PMC10580625
doi:
Substances chimiques
Sodium
9NEZ333N27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
666Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Am J Kidney Dis. 2016 Jun;67(6):893-901
pubmed: 26874645
Dtsch Arztebl Int. 2016 Dec 16;113(50):855-862
pubmed: 28098064
Sci Rep. 2019 Aug 29;9(1):12526
pubmed: 31467370
Int J Older People Nurs. 2007 Sep;2(3):204-12
pubmed: 20925877
BMC Emerg Med. 2018 Nov 15;18(1):41
pubmed: 30442112
Am J Med. 2006 Jul;119(7 Suppl 1):S30-5
pubmed: 16843082
Open Med (Wars). 2018 Mar 15;13:22-28
pubmed: 29577092
Clin J Am Soc Nephrol. 2018 Mar 7;13(3):366-374
pubmed: 29439092
Int Psychogeriatr. 2009 Feb;21(1):123-8
pubmed: 18983719
Am J Med. 2013 Oct;126(10 Suppl 1):S1-42
pubmed: 24074529
Gerontology. 2012;58(5):430-40
pubmed: 22722883
PLoS One. 2017 Jun 7;12(6):e0178977
pubmed: 28591195
J Bone Miner Res. 2015 Jun;30(6):970-5
pubmed: 25294595
Am J Med. 2006 Jan;119(1):71.e1-8
pubmed: 16431193
J Korean Med Sci. 2017 May;32(5):868-872
pubmed: 28378563