Clinical study of drug-loaded calcium sulfate in the treatment of hematogenous osteomyelitis in children.
Children
Drug-laden calcium sulfate
Hematogenous osteomyelitis
Vancomycin
Journal
BMC musculoskeletal disorders
ISSN: 1471-2474
Titre abrégé: BMC Musculoskelet Disord
Pays: England
ID NLM: 100968565
Informations de publication
Date de publication:
17 Oct 2023
17 Oct 2023
Historique:
received:
08
06
2023
accepted:
08
10
2023
medline:
23
10
2023
pubmed:
18
10
2023
entrez:
17
10
2023
Statut:
epublish
Résumé
At present, good results have been obtained in the treatment of hematogenous osteomyelitis(HO) in children by the use of drug-loaded calcium sulfate, but there are few clinical studies reported. The aim of this study was to investigate the clinical efficacy of radical debridement combined with drug-laden calcium sulphate antibiotics in paediatric haematogenous osteomyelitis. In this study, we retrospectively analyzed the clinical data of 15 cases of pediatric hematogenous osteomyelitis admitted to our hospital in recent years. A total of 15 pediatric patients with HO treated in our hospital from January 2018 to February 2022 were included for evaluation. All 15 patients were treated with drug-laden calcium sulfate, and the antibiotic of choice was vancomycin in 14 cases and vancomycin combined with gentamicin in 1 case. The follow-up period ranged from 12 to 36 months, with a mean follow-up time of 24.73 months, and all children were treated with drug-laden calcium sulfate with satisfactory clinical outcomes. The results of serological examination showed that the preoperative white blood cell count level, C-reactive protein and erythrocyte sedimentation rate were higher than the postoperative ones, and the differences were statistically significant (P < 0.05).After the operation, referring to the treatment standard of McKee's osteomyelitis, 15 cases were cured without recurrence; According to the Lower Extremities Functional Scale, 12 cases were excellent, 2 cases were good and 1 case was moderate, with an excellent rate of 93.33%. Children with lower limb involvement could walk with full weight bearing, and gait was basically normal. Drug-loaded calcium sulfate is a good therapeutic method for the treatment of hematogenous osteomyelitis in children, with a effect of reducing complications and reducing recurrence.
Sections du résumé
BACKGROUND
BACKGROUND
At present, good results have been obtained in the treatment of hematogenous osteomyelitis(HO) in children by the use of drug-loaded calcium sulfate, but there are few clinical studies reported. The aim of this study was to investigate the clinical efficacy of radical debridement combined with drug-laden calcium sulphate antibiotics in paediatric haematogenous osteomyelitis.
METHODS
METHODS
In this study, we retrospectively analyzed the clinical data of 15 cases of pediatric hematogenous osteomyelitis admitted to our hospital in recent years. A total of 15 pediatric patients with HO treated in our hospital from January 2018 to February 2022 were included for evaluation.
RESULTS
RESULTS
All 15 patients were treated with drug-laden calcium sulfate, and the antibiotic of choice was vancomycin in 14 cases and vancomycin combined with gentamicin in 1 case. The follow-up period ranged from 12 to 36 months, with a mean follow-up time of 24.73 months, and all children were treated with drug-laden calcium sulfate with satisfactory clinical outcomes. The results of serological examination showed that the preoperative white blood cell count level, C-reactive protein and erythrocyte sedimentation rate were higher than the postoperative ones, and the differences were statistically significant (P < 0.05).After the operation, referring to the treatment standard of McKee's osteomyelitis, 15 cases were cured without recurrence; According to the Lower Extremities Functional Scale, 12 cases were excellent, 2 cases were good and 1 case was moderate, with an excellent rate of 93.33%. Children with lower limb involvement could walk with full weight bearing, and gait was basically normal.
CONCLUSION
CONCLUSIONS
Drug-loaded calcium sulfate is a good therapeutic method for the treatment of hematogenous osteomyelitis in children, with a effect of reducing complications and reducing recurrence.
Identifiants
pubmed: 37848868
doi: 10.1186/s12891-023-06948-z
pii: 10.1186/s12891-023-06948-z
pmc: PMC10580590
doi:
Substances chimiques
Vancomycin
6Q205EH1VU
Calcium Sulfate
WAT0DDB505
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
822Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
J Biomater Appl. 2019 Aug;34(2):250-260
pubmed: 31088183
BMC Pediatr. 2008 Oct 20;8:45
pubmed: 18937840
BMC Pediatr. 2022 Dec 23;22(1):732
pubmed: 36564727
BMC Musculoskelet Disord. 2022 Dec 23;23(1):1124
pubmed: 36564738
J Biomater Appl. 2016 May;30(10):1534-44
pubmed: 26847915
J Orthop Surg Res. 2022 Feb 19;17(1):104
pubmed: 35183215
J Pediatric Infect Dis Soc. 2021 Sep 23;10(8):801-844
pubmed: 34350458
J Bone Joint Surg Br. 2012 May;94(5):584-95
pubmed: 22529075
J Pediatr Orthop B. 2019 May;28(3):189-195
pubmed: 29851713
Clin Orthop Surg. 2011 Mar;3(1):1-8
pubmed: 21369472
BMC Musculoskelet Disord. 2016 Dec 22;17(1):502
pubmed: 28007027
Injury. 2019 Feb;50(2):508-514
pubmed: 30447985
Ann Med Surg (Lond). 2022 Sep 08;82:104578
pubmed: 36268342
J Pediatr Orthop. 2017 Apr/May;37(3):222-226
pubmed: 26280295
J Orthop Trauma. 2020 Jan;34(1):30-41
pubmed: 31567902
J Orthop Trauma. 2010 Aug;24(8):483-90
pubmed: 20657257
J Pediatr Orthop B. 2011 Nov;20(6):432-5
pubmed: 21460736
J Pediatr Orthop. 2021 Feb 1;41(2):127-131
pubmed: 33284138
J Biomed Mater Res B Appl Biomater. 2015 May;103(4):870-7
pubmed: 25142105
Expert Rev Anti Infect Ther. 2010 Feb;8(2):175-81
pubmed: 20109047
Curr Opin Pediatr. 2013 Feb;25(1):58-63
pubmed: 23283291