Partial sternectomy with reconstruction of a giant cell tumor of the sternum, a case report, Saudi, Arabia.
Giant cell tumors
Sternum
Subtotal sternectomy
Journal
Journal of cardiothoracic surgery
ISSN: 1749-8090
Titre abrégé: J Cardiothorac Surg
Pays: England
ID NLM: 101265113
Informations de publication
Date de publication:
17 Oct 2023
17 Oct 2023
Historique:
received:
30
01
2023
accepted:
30
09
2023
medline:
23
10
2023
pubmed:
18
10
2023
entrez:
17
10
2023
Statut:
epublish
Résumé
Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor that rarely affects the sternum. We report a case of giant cell tumor of the sternum in a 28-year-old Saudi with painful swelling at the lower part of the sternum. Subtotal sternectomy and reconstruction with a neosternum using two layers of proline mesh, a methyl methacrylate prosthesis, and bilateral pectoralis muscle advancement flaps were performed. Giant cell tumor of the sternum is a rare diagnosis. Surgical resection with negative margins is the ideal management. To avoid defects or instability of the chest wall, reconstruction of the chest wall with neosternum should be considered.
Sections du résumé
BACKGROUND
BACKGROUND
Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor that rarely affects the sternum.
CASE PRESENTATION
METHODS
We report a case of giant cell tumor of the sternum in a 28-year-old Saudi with painful swelling at the lower part of the sternum. Subtotal sternectomy and reconstruction with a neosternum using two layers of proline mesh, a methyl methacrylate prosthesis, and bilateral pectoralis muscle advancement flaps were performed.
CONCLUSIONS
CONCLUSIONS
Giant cell tumor of the sternum is a rare diagnosis. Surgical resection with negative margins is the ideal management. To avoid defects or instability of the chest wall, reconstruction of the chest wall with neosternum should be considered.
Identifiants
pubmed: 37848912
doi: 10.1186/s13019-023-02404-0
pii: 10.1186/s13019-023-02404-0
pmc: PMC10580503
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
296Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Imaduddin M, Ayyanar P, Sultania M, Muduly D, Sable MN, Naik S, et al. Primary malignant giant cell tumor of the sternum. Autops Case Rep. 2021;11:e2021281. https://doi.org/10.4322/acr.2021.281 .
doi: 10.4322/acr.2021.281
pubmed: 34249788
Muramatsu K, Tani Y, Seto T, Roces G, Yamamoto M, Ichihara Y, et al. Two cases with giant cell tumor arising from the sternum: diagnosis and options for treatment. J Orthop Sci. 2022;27(5):1143–8. https://doi.org/10.1016/j.jos.2019.10.014 .
doi: 10.1016/j.jos.2019.10.014
pubmed: 32001081
Fattahi SH, Yousefi Y, Moghimi A. Primary and secondary tumors of the sternum. J Cardiothoracic Med. 2020;8(1):584–6.
Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica. 2021;113(2):70–84. https://doi.org/10.32074/1591-951X-213 .
doi: 10.32074/1591-951X-213
pubmed: 33179614
Van der Heijden L, Dijkstra PD, van de Sande MA, Kroep JR, Nout RA, van Rijswijk CS, et al. The clinical approach toward giant cell tumor of bone. Oncologist. 2014;19(5):550–61. https://doi.org/10.1634/theoncologist.2013-0432 .
doi: 10.1634/theoncologist.2013-0432
pubmed: 24718514
Singh A, Chandrashekhara SH, Triveni GS, Kumar P. Imaging in sternal tumours: a pictorial review. Pol J Radiol. 2017;82:448–56. https://doi.org/10.12659/PJR.901226 .
doi: 10.12659/PJR.901226
pubmed: 29662571
Abate E, Banki F, Hagen JA, Klipfel N. Giant cell tumor of the sternum. Ann Thorac Surg. 2009;88:645–7.
doi: 10.1016/j.athoracsur.2008.12.059
pubmed: 19632429
Gritsiuta AI, Bracken A, Downs P, Lara-Gutierrez J, Beebe K, Pechetov AA, et al. Surgical management of rare benign tumors of the sternum. MOJ Clin Med Case Rep. 2021;11(3):88–94. https://doi.org/10.15406/mojcr.2021.11.00389 .
doi: 10.15406/mojcr.2021.11.00389
pubmed: 34395895
Song Y, Kwon JW. Percutaneous CT-guided sternal biopsy: factors affecting the diagnostic yield. Acta Radiol. 2017;58(7):825–33.
doi: 10.1177/0284185116676652
pubmed: 27852642
Montgomery C, Couch C, Emory CL, Nicholas R. Giant cell tumor of bone: review of current literature, evaluation, and treatment options. J Knee Surg. 2019;32:331–6.
doi: 10.1055/s-0038-1675815
pubmed: 30449024
De Salvo S, Pavone V, Coco S, Dell’Agli E, Blatti C, Testa G. Benign bone tumors: an overview of what we know today. J Clin Med. 2022;11:699. https://doi.org/10.3390/jcm11030699 .
doi: 10.3390/jcm11030699
pubmed: 35160146
Kato I, Furuya M, Matsuo K, Kawabata Y, Tanaka R, Ohashi K. Giant cell tumours of bone treated with denosumab: histological, immunohistochemical and H3F3A mutation analyses. Histopathology. 2018;72(6):914–22. https://doi.org/10.1111/his.13448 .
doi: 10.1111/his.13448
pubmed: 29206281
Kerr DA, Brcic I, Diaz-Perez JA, Shih A, Wilky BA, Pretell-Mazzini J, et al. Immunohistochemical characterization of giant cell tumor of bone treated with denosumab: support for osteoblastic differentiation. Am J Surg Pathol. 2021;45(1):93–100. https://doi.org/10.1097/PAS.0000000000001555 .
doi: 10.1097/PAS.0000000000001555
pubmed: 32773532
Futani H, Okumura Y, Fukuda Y, Fukunaga S, Hasegawa S, Yoshiya S. Giant cell tumor of the sternum: a case report and review of the literature. Anticancer Res. 2008;28(6B):4117–20.
pubmed: 19192670
Ruka W, Rutkowski P, Morysiński T, Nowecki Z, Zdzienicki M, Makula D, et al. The megavoltage radiation therapy in treatment of patients with advanced or difficult giant cell tumors of bone. Int J Radiat Oncol Biol Phys. 2010;78(2):494–8.
doi: 10.1016/j.ijrobp.2009.07.1704
pubmed: 20004531
He SH, Xu W, Sun ZW, Liu WB, Liu YJ, Wei HF, et al. Selective arterial embolization for the treatment of sacral and pelvic giant cell tumor: a systematic review. Orthop Surg. 2017;9(2):139–44.
doi: 10.1111/os.12336
pubmed: 28644557
Kaban LB, Troulis MJ, Ebb D, August M, Hornicek FJ, Dodson TB. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 2002;60(10):1103–11.
doi: 10.1053/joms.2002.34975
pubmed: 12378481
Li H, Gao J, Gao Y, Lin N, Zheng M, Ye Z. Denosumab in giant cell tumor of bone: current status and pitfalls. Front Oncol. 2020;10:580605. https://doi.org/10.3389/fonc.2020.580605 .
doi: 10.3389/fonc.2020.580605
pubmed: 33123484
Singh AS, Chawla NS, Chawla SP. Giant-cell tumor of bone: treatment options and role of denosumab. Biologics. 2015;9:69–74.
pubmed: 26203221
Traub F, Singh J, Dickson BC, Leung S, Mohankumar R, Blackstein ME, et al. Efficacy of denosumab in joint preservation for patients with giant cell tumour of the bone. Eur J Cancer. 2016;59:1–12. https://doi.org/10.1016/j.ejca.2016.01.006 .
doi: 10.1016/j.ejca.2016.01.006
pubmed: 26990281