Exploring alternative approaches to precision medicine through genomics and artificial intelligence - a systematic review.

artificial intelligence biomarkers genomics humans precision medicine

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2023
Historique:
received: 22 05 2023
accepted: 20 09 2023
medline: 18 10 2023
pubmed: 18 10 2023
entrez: 18 10 2023
Statut: epublish

Résumé

The core idea behind precision medicine is to pinpoint the subpopulations that differ from one another in terms of disease risk, drug responsiveness, and treatment outcomes due to differences in biology and other traits. Biomarkers are found through genomic sequencing. Multi-dimensional clinical and biological data are created using these biomarkers. Better analytic methods are needed for these multidimensional data, which can be accomplished by using artificial intelligence (AI). An updated review of 80 latest original publications is presented on four main fronts-preventive medicine, medication development, treatment outcomes, and diagnostic medicine-All these studies effectively illustrated the significance of AI in precision medicine. Artificial intelligence (AI) has revolutionized precision medicine by swiftly analyzing vast amounts of data to provide tailored treatments and predictive diagnostics. Through machine learning algorithms and high-resolution imaging, AI assists in precise diagnoses and early disease detection. AI's ability to decode complex biological factors aids in identifying novel therapeutic targets, allowing personalized interventions and optimizing treatment outcomes. Furthermore, AI accelerates drug discovery by navigating chemical structures and predicting drug-target interactions, expediting the development of life-saving medications. With its unrivaled capacity to comprehend and interpret data, AI stands as an invaluable tool in the pursuit of enhanced patient care and improved health outcomes. It's evident that AI can open a new horizon for precision medicine by translating complex data into actionable information. To get better results in this regard and to fully exploit the great potential of AI, further research is required on this pressing subject.

Identifiants

pubmed: 37849490
doi: 10.3389/fmed.2023.1227168
pmc: PMC10577305
doi:

Types de publication

Systematic Review

Langues

eng

Pagination

1227168

Informations de copyright

Copyright © 2023 Mumtaz, Saqib, Jabeen, Muneeb, Mughal, Sohail, Safdar, Mehmood, Khan and Ismail.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Lancet Oncol. 2018 Jul;19(7):916-929
pubmed: 29908991
PLoS One. 2017 Apr 5;12(4):e0174866
pubmed: 28379999
PLoS One. 2020 Feb 27;15(2):e0229596
pubmed: 32106247
PLoS One. 2019 Jun 19;14(6):e0218253
pubmed: 31216310
Campbell Syst Rev. 2022 Mar 27;18(2):e1230
pubmed: 36911350
PLoS One. 2021 May 17;16(5):e0251800
pubmed: 33999966
PLoS One. 2021 Feb 19;16(2):e0247203
pubmed: 33606819
PLoS One. 2019 Jul 11;14(7):e0219774
pubmed: 31295321
J Invest Dermatol. 2020 May;140(5):1026-1034
pubmed: 31705874
AJNR Am J Neuroradiol. 2020 Mar;41(3):400-407
pubmed: 32029466
Cancer Imaging. 2020 Nov 23;20(1):83
pubmed: 33228815
J Psychiatr Res. 2018 Apr;99:62-68
pubmed: 29407288
PLoS One. 2019 Apr 18;14(4):e0215508
pubmed: 30998730
Artif Intell Med. 2021 Oct;120:102161
pubmed: 34629149
Sensors (Basel). 2021 Feb 21;21(4):
pubmed: 33670066
PLoS One. 2019 Mar 8;14(3):e0213292
pubmed: 30849111
IEEE J Transl Eng Health Med. 2019 Nov 07;7:1900808
pubmed: 32166049
Comput Methods Programs Biomed. 2015 Jan;118(1):69-76
pubmed: 25453384
PLoS One. 2017 Apr 10;12(4):e0175383
pubmed: 28394905
EBioMedicine. 2018 Nov;37:91-100
pubmed: 30361063
Surgery. 2019 May;165(5):1035-1045
pubmed: 30792011
Crit Care. 2021 Mar 19;25(1):114
pubmed: 33741010
PLoS One. 2018 Dec 7;13(12):e0208924
pubmed: 30532223
Psychol Med. 2021 Jan;51(2):279-289
pubmed: 31753043
PLoS One. 2021 Mar 31;16(3):e0248526
pubmed: 33788887
PLoS One. 2017 Oct 26;12(10):e0186906
pubmed: 29073279
PLoS One. 2020 Aug 25;15(8):e0237698
pubmed: 32842139
Nature. 2017 Jul 13;547(7662):217-221
pubmed: 28678778
Neuroimage. 2020 Jul 15;215:116807
pubmed: 32278897
Neuropsychopharmacology. 2018 Oct;43(11):2221-2230
pubmed: 29955151
PLoS One. 2020 Aug 13;15(8):e0237332
pubmed: 32790761
PLoS One. 2020 Apr 6;15(4):e0231227
pubmed: 32251447
Microbiome. 2020 Nov 19;8(1):162
pubmed: 33213511
PLoS One. 2019 Sep 9;14(9):e0222270
pubmed: 31498836
PLoS One. 2018 Nov 21;13(11):e0207455
pubmed: 30462705
PLoS One. 2021 Nov 12;16(11):e0258400
pubmed: 34767577
PLoS One. 2018 Oct 5;13(10):e0205155
pubmed: 30289891
PLoS One. 2020 Apr 6;15(4):e0231059
pubmed: 32251458
PLoS One. 2018 Sep 20;13(9):e0204161
pubmed: 30235308
PLoS One. 2017 Aug 24;12(8):e0183273
pubmed: 28837668
PLoS One. 2018 Jul 26;13(7):e0200699
pubmed: 30048465
PLoS One. 2018 Oct 16;13(10):e0204493
pubmed: 30325934
PLoS One. 2018 Oct 31;13(10):e0206351
pubmed: 30379950
PLoS One. 2018 Aug 31;13(8):e0202344
pubmed: 30169498
Biometrics. 2020 Sep;76(3):778-788
pubmed: 31743424
PLoS One. 2019 Oct 2;14(10):e0218642
pubmed: 31577805
Abdom Radiol (NY). 2021 Mar;46(3):1053-1061
pubmed: 32940759
J Am Soc Nephrol. 2019 Aug;30(8):1514-1522
pubmed: 31270136
PLoS One. 2018 Dec 14;13(12):e0208082
pubmed: 30550560
Brain Stimul. 2020 Nov - Dec;13(6):1753-1764
pubmed: 33049412
PLoS One. 2020 Dec 17;15(12):e0243615
pubmed: 33332440
Clin Cancer Res. 2005 Nov 1;11(21):7872-8
pubmed: 16278411
Stroke. 2017 Jun;48(6):1678-1681
pubmed: 28438906
PLoS One. 2020 Jul 2;15(7):e0235424
pubmed: 32614874
PLoS One. 2021 Mar 31;16(3):e0248375
pubmed: 33788842
PLoS One. 2019 Mar 25;14(3):e0214133
pubmed: 30908513
Brief Bioinform. 2023 Jan 19;24(1):
pubmed: 36545790
PLoS One. 2017 Apr 4;12(4):e0174944
pubmed: 28376093
Kidney Int. 2005 May;67(5):1944-54
pubmed: 15840042
PLoS One. 2017 May 23;12(5):e0177726
pubmed: 28542342
PLoS One. 2019 Jul 10;14(7):e0219452
pubmed: 31291347
PLoS One. 2019 Jul 8;14(7):e0218942
pubmed: 31283759
PLoS One. 2018 Nov 14;13(11):e0207096
pubmed: 30427908
PLoS One. 2018 Jun 5;13(6):e0198116
pubmed: 29870556
PLoS One. 2019 Apr 4;14(4):e0215133
pubmed: 30947300
Neuroimage. 2018 Jun;173:421-433
pubmed: 29471100
PLoS One. 2016 Sep 15;11(9):e0162407
pubmed: 27632168
PLoS One. 2019 Mar 29;14(3):e0214587
pubmed: 30925170
JAMA Netw Open. 2020 Jun 1;3(6):e206653
pubmed: 32568399
PLoS One. 2018 Aug 8;13(8):e0198603
pubmed: 30089110
PLoS One. 2020 May 22;15(5):e0232639
pubmed: 32442178
PLoS One. 2017 Sep 7;12(9):e0184109
pubmed: 28880900
PLoS One. 2019 Aug 9;14(8):e0220711
pubmed: 31398194
PLoS One. 2020 Sep 30;15(9):e0239934
pubmed: 32997716
Sci Rep. 2018 Sep 27;8(1):14487
pubmed: 30262838
PLoS One. 2021 Sep 7;16(9):e0256630
pubmed: 34492046
PLoS One. 2020 Dec 17;15(12):e0243641
pubmed: 33332409
PLoS One. 2018 Nov 28;13(11):e0206686
pubmed: 30485296
Sci Rep. 2021 Jun 29;11(1):13445
pubmed: 34188141
Lung Cancer. 2018 Oct;124:6-11
pubmed: 30268481
Dis Colon Rectum. 2020 Feb;63(2):143-151
pubmed: 31842158
PLoS One. 2020 Apr 23;15(4):e0232103
pubmed: 32324812
PLoS One. 2017 Mar 3;12(3):e0169490
pubmed: 28257413
PLoS One. 2019 Apr 10;14(4):e0213836
pubmed: 30970030
PLoS One. 2021 Sep 10;16(9):e0238757
pubmed: 34506489
Psychol Med. 2019 May;49(7):1118-1127
pubmed: 29962359
PLoS One. 2021 May 21;16(5):e0252068
pubmed: 34019601
PLoS One. 2019 Feb 27;14(2):e0212108
pubmed: 30811440

Auteurs

Hassan Mumtaz (H)

Maroof International Hospital, Islamabad, Pakistan.

Muhammad Saqib (M)

Khyber Medical College, Peshawar, Pakistan.

Sidra Jabeen (S)

Liaquat National Hospital, Karachi, Pakistan.

Muhammad Muneeb (M)

Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Wajiha Mughal (W)

Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Hassan Sohail (H)

Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Myra Safdar (M)

Armed Forces Institute of Cardiology and National Institute of Heart Diseases (AFIC-NIHD), Rawalpindi, Pakistan.

Qasim Mehmood (Q)

Department of Medicine, King Edward Medical University, Lahore, Pakistan.

Muhammad Ahsan Khan (MA)

Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Syed Muhammad Ismail (SM)

Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.

Classifications MeSH