A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus.
Arachidonic acid 15-Lipoxygenase
Diabetes mellitus
Diabetic kidney disease
Ferroptosis
Inflammatory response
Oxidative stress
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2023
2023
Historique:
received:
13
03
2023
accepted:
14
09
2023
medline:
23
10
2023
pubmed:
18
10
2023
entrez:
18
10
2023
Statut:
epublish
Résumé
Arachidonic acid 15-lipoxygenase (ALOX15), as one of the lipoxygenase family, is mainly responsible for catalyzing the oxidation of various fatty acids to produce a variety of lipid components, contributing to the pathophysiological processes of various immune and inflammatory diseases. Studies have shown that ALOX15 and its related products are widely distributed in human tissues and related to multiple diseases such as liver, cardiovascular, cerebrovascular diseases, diabetes mellitus and other diseases. Diabetes mellitus (DM), the disease studied in this article, is a metabolic disease characterized by a chronic increase in blood glucose levels, which is significantly related to inflammation, oxidative stress, ferroptosis and other mechanisms, and it has a high incidence in the population, accompanied by a variety of complications. Figuring out how ALOX15 is involved in DM is critical to understanding its role in diseases. Therefore, ALOX15 inhibitors or combination therapy containing inhibitors may deliver a novel research direction for the treatment of DM and its complications. This article aims to review the biological effect and the possible function of ALOX15 in the pathogenesis of DM.
Identifiants
pubmed: 37849828
doi: 10.7717/peerj.16239
pii: 16239
pmc: PMC10578307
doi:
Substances chimiques
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
Fatty Acids
0
ALOX15 protein, human
EC 1.13.11.33
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e16239Informations de copyright
©2023 He et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
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