An Overview of Antiviral Peptides and Rational Biodesign Considerations.
Journal
Biodesign research
ISSN: 2693-1257
Titre abrégé: Biodes Res
Pays: United States
ID NLM: 9918469288306676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
01
2022
accepted:
04
04
2022
medline:
17
5
2022
pubmed:
17
5
2022
entrez:
18
10
2023
Statut:
epublish
Résumé
Viral diseases have contributed significantly to worldwide morbidity and mortality throughout history. Despite the existence of therapeutic treatments for many viral infections, antiviral resistance and the threat posed by novel viruses highlight the need for an increased number of effective therapeutics. In addition to small molecule drugs and biologics, antimicrobial peptides (AMPs) represent an emerging class of potential antiviral therapeutics. While AMPs have traditionally been regarded in the context of their antibacterial activities, many AMPs are now known to be antiviral. These antiviral peptides (AVPs) have been shown to target and perturb viral membrane envelopes and inhibit various stages of the viral life cycle, from preattachment inhibition through viral release from infected host cells. Rational design of AMPs has also proven effective in identifying highly active and specific peptides and can aid in the discovery of lead peptides with high therapeutic selectivity. In this review, we highlight AVPs with strong antiviral activity largely curated from a publicly available AMP database. We then compile the sequences present in our AVP database to generate structural predictions of generic AVP motifs. Finally, we cover the rational design approaches available for AVPs taking into account approaches currently used for the rational design of AMPs.
Identifiants
pubmed: 37850133
doi: 10.34133/2022/9898241
pii: 9898241
pmc: PMC10521750
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
9898241Informations de copyright
Copyright © 2022 Ying-Chiang J. Lee et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this article.
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