Peppermint as a promising treatment agent in inflammatory conditions: A comprehensive systematic review of literature.
antiinflammatory agent
inflammation
peppermint
systematic review
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
18 Oct 2023
18 Oct 2023
Historique:
revised:
12
09
2023
received:
25
04
2023
accepted:
30
09
2023
medline:
18
10
2023
pubmed:
18
10
2023
entrez:
18
10
2023
Statut:
aheadofprint
Résumé
Inflammation, a type of the body's defense against injury or infection, causes many chronic disorders including diabetes, cardiovascular disease, and cancer. Therefore, discovering natural compounds with numerous biological activities for the management of inflammation is highly recommended. Out of natural compounds, peppermint and its main component, menthol, has been suggested to possess antiinflammatory potential. Four databases including Web of Sciences, PubMed, Scopus, and Embase were searched to identify articles about peppermint and its antiinflammatory effects up to March 2023. Out of 3805 records screened, 14 articles met the study criteria. The evidence reviewed here proposed peppermint as an antiinflammatory agent. Peppermint may suppress inflammation by activating the AMP-activated protein kinase/unc-51 like kinase 1/nuclear factor-E2 associated factor 2 autophagy pathway, downregulating extracellular signal-regulated kinase-nuclear factor kappa B and mitogen activated protein kinases pathways, attenuating oxidative stress, suppressing the production of pro-inflammatory mediators and nitric oxide, and inducing the production of antiinflammatory prostaglandins. Due to the promising antiinflammatory effects of peppermint and the lack of human studies in this regard, future randomized clinical trials examining the effects of peppermint on inflammation and its related maladies are warranted.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
Abdolmaleki, A., Rajabi, A., & Sanginabadi, F. (2013). Evaluation of the analgesic and anti-inflammatory effects of aqueous extract of peppermint (Mentha piperita). HBI Journals, 18(1), 67-74.
Alliger, K., Khalil, M., König, B., Weisenburger, S., Koch, E., & Engel, M. (2020). Menthacarin attenuates experimental colitis. Phytomedicine, 77, 153212.
Atta, A. H., & Alkofahi, A. (1998). Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. Journal of Ethnopharmacology, 60(2), 117-124.
Bastaki, S. M., Adeghate, E., Amir, N., Ojha, S., & Oz, M. (2018). Menthol inhibits oxidative stress and inflammation in acetic acid-induced colitis in rat colonic mucosa. American Journal of Translational Research, 10(12), 4210-4222.
Caro, D. C., Rivera, D. E., Ocampo, Y., Franco, L. A., & Salas, R. D. (2018). Pharmacological evaluation of Mentha spicata L. and Plantago major L., medicinal plants used to treat anxiety and insomnia in Colombian Caribbean coast. Evidence-Based Complementary and Alternative Medicine, 2018, 5921514.
Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2018). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204-7218.
Cronkite, D. A., & Strutt, T. M. (2018). The regulation of inflammation by innate and adaptive lymphocytes. Journal of Immunology Research, 2018, 1467538.
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., Miller, A. H., Mantovani, A., Weyand, C. M., Barzilai, N., Goronzy, J. J., Rando, T. A., Effros, R. B., Lucia, A., Kleinstreuer, N., & Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25(12), 1822-1832.
Ghasemi-Pirbaluti, M., Motaghi, E., & Bozorgi, H. (2017). The effect of menthol on acute experimental colitis in rats. European Journal of Pharmacology, 805, 101-107.
Graham-Engeland, J. E., Sin, N. L., Smyth, J. M., Jones, D. R., Knight, E. L., Sliwinski, M. J., Almeida, D. M., Katz, M. J., Lipton, R. B., & Engeland, C. G. (2018). Negative and positive affect as predictors of inflammation: Timing matters. Brain, Behavior, and Immunity, 74, 222-230.
Hanafy, D. M., Burrows, G. E., Prenzler, P. D., & Hill, R. A. (2020). Potential role of phenolic extracts of Mentha in managing oxidative stress and Alzheimer's disease. Antioxidants (Basel, Switzerland), 9(7), 631.
Hejna, M., Kovanda, L., Rossi, L., & Liu, Y. (2021). Mint oils: In vitro ability to perform anti-inflammatory, antioxidant, and antimicrobial activities and to enhance intestinal barrier integrity. Antioxidants (Basel, Switzerland), 10(7), 1004.
Juergens, U. R., Stöber, M., & Vetter, H. (1998). The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: A novel perspective for its therapeutic use in inflammatory diseases. European Journal of Medical Research, 3(12), 539-545.
Kehili, S., Boukhatem, M. N., Belkadi, A., Ferhat, M. A., & Setzer, W. N. (2020). Peppermint (Mentha piperita L.) essential oil as a potent anti-inflammatory, wound healing and anti-nociceptive drug. European Journal of Biological Research, 10, 132-149.
Keifer, D., Ulbricht, C., Abrams, T. R., Basch, E., Giese, N., Giles, M., DeFranco Kirkwood, C., Miranda, M., & Woods, J. (2007). Peppermint (Mentha piperita): An evidence-based systematic review by the natural standard research collaboration. Journal of Herbal Pharmacotherapy, 7(2), 91-143.
Kim, S. Y., Han, S. D., Kim, M., Mony, T. J., Lee, E. S., Kim, K. M., Choi, S. H., Hong, S. H., Choi, J. W., & Park, S. J. (2021). Mentha arvensis essential oil exerts anti-inflammatory in LPS-stimulated inflammatory responses via inhibition of ERK/NF-κB signaling pathway and anti-atopic dermatitis-like effects in 2,4-dinitrochlorobezene-induced BALB/c mice. Antioxidants (Basel, Switzerland), 10(12), 1941.
Liu, S., Guo, W., Jia, Y., Ye, B., Liu, S., Fu, S., Liu, J., & Hu, G. (2021). Menthol targeting AMPK alleviates the inflammatory response of bovine mammary epithelial cells and restores the synthesis of milk fat and milk protein. Frontiers in Immunology, 12, 782989.
Madsen, C., Würtzen, G., & Carstensen, J. (1986). Short-term toxicity study in rats dosed with menthone. Toxicology Letters, 32(1-2), 147-152.
Modarresi, M., Farahpour, M. R., & Baradaran, B. (2019). Topical application of Mentha piperita essential oil accelerates wound healing in infected mice model. Inflammopharmacology, 27(3), 531-537.
Mogosan, C., Vostinaru, O., Oprean, R., Heghes, C., Filip, L., Balica, G., & Moldovan, R. (2017). A comparative analysis of the chemical composition, anti-inflammatory, and antinociceptive effects of the essential oils from three species of mentha cultivated in Romania. Molecules (Basel, Switzerland), 22(2), 263.
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine, 6(7), e1000097.
Peiris, M., Weerts, Z. Z. R., Aktar, R., Masclee, A. A., Blackshaw, A., & Keszthelyi, D. (2021). A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome-An exploratory study. Neurogastroenterology & Motility, 33(9), e14170.
Rozza, A., Hiruma-Lima, C., Takahira, R. K., Padovani, C., & Pellizzon, C. (2013). Effect of menthol in experimentally induced ulcers: Pathways of gastroprotection. Chemico-Biological Interactions, 206(2), 272-278.
Singh, S., Bhatt, D., Singh, M. K., Maurya, A. K., Israr, K. M. M., Chauhan, A., Padalia, R. C., Verma, R. S., & Bawankule, D. U. (2022). p-Menthadienols-rich essential oil from Cymbopogon martini ameliorates skin inflammation. Inflammopharmacology, 30(3), 895-905.
Sun, Z., Wang, H., Wang, J., Zhou, L., & Yang, P. (2014). Chemical composition and anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita grown in China. PLoS One, 9(12), e114767.
Vonkeman, H. E., & van de Laar, M. A. (2010). Nonsteroidal anti-inflammatory drugs: Adverse effects and their prevention. Seminars in Arthritis and Rheumatism, 39(4), 294-312.
Zaia, M. G., Cagnazzo, T., Feitosa, K. A., Soares, E. G., Faccioli, L. H., Allegretti, S. M., Afonso, A., & Anibal, F. D. (2016). Anti-inflammatory properties of menthol and menthone in Schistosoma mansoni infection. Frontiers in Pharmacology, 7, 170.
Zhao, H., Ren, S., Yang, H., Tang, S., Guo, C., Liu, M., Tao, Q., Ming, T., & Xu, H. (2022). Peppermint essential oil: Its phytochemistry, biological activity, pharmacological effect and application. Biomedicine & Pharmacotherapy, 154, 113559.
Zhao, Q., Zhu, L., Wang, S., Gao, Y., & Jin, F. (2023). Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review. Journal of Ethnopharmacology, 301, 115829.