Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins.
cardiac imaging
cardiomyopathy
computational biology
computer modeling
electrophysiology
genetics
human
systems biology
ventricular arrhythmia
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
18 10 2023
18 10 2023
Historique:
medline:
23
10
2023
pubmed:
18
10
2023
entrez:
18
10
2023
Statut:
epublish
Résumé
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease that leads to ventricular tachycardia (VT), a life-threatening heart rhythm disorder. Treating ARVC remains challenging due to the complex underlying arrhythmogenic mechanisms, which involve structural and electrophysiological (EP) remodeling. Here, we developed a novel genotype-specific heart digital twin (Geno-DT) approach to investigate the role of pathophysiological remodeling in sustaining VT reentrant circuits and to predict the VT circuits in ARVC patients of different genotypes. This approach integrates the patient's disease-induced structural remodeling reconstructed from contrast-enhanced magnetic-resonance imaging and genotype-specific cellular EP properties. In our retrospective study of 16 ARVC patients with two genotypes: plakophilin-2 (
Identifiants
pubmed: 37851708
doi: 10.7554/eLife.88865
pii: 88865
pmc: PMC10584370
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142496
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126802
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007227
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL165535
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023, Zhang et al.
Déclaration de conflit d'intérêts
YZ, KZ, AP, CJ, SZ, RC, ES, AG, CT, BM, HC, NT No competing interests declared
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