Expanding the synthesis of a library of potent glucuronic acid glycodendrons for Dengue virus inhibition.
Carbohydrate-Protein interactions
Click chemistry
Dengue virus
Glucuronic acid
Glycodendrons
Glycosaminoglycan mimetics
Multivalency
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
14
08
2023
revised:
28
09
2023
accepted:
08
10
2023
medline:
3
11
2023
pubmed:
19
10
2023
entrez:
18
10
2023
Statut:
ppublish
Résumé
Multivalent glycodendrons are valuable tools to mimic many structural and functional features of cell-surface glycoconjugates and its focal position scaffolds represent important components to increase specificity and affinity. Previous work in our group described the preparation of a tetravalent glucuronic acid dendron that binds with good affinity to Dengue virus envelope protein (K
Identifiants
pubmed: 37852115
pii: S0045-2068(23)00574-6
doi: 10.1016/j.bioorg.2023.106913
pii:
doi:
Substances chimiques
Glucuronic Acid
8A5D83Q4RW
Azides
0
Viral Envelope Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106913Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: María J Hernáiz reports financial support was provided by Complutense University of Madrid. María J Hernáiz reports a relationship with Complutense University of Madrid that includes: employment. No conflict of interest.