An increase in a long noncoding RNA ANRIL in peripheral plasma is an indicator of stable angina.
ANRIL
Acute coronary syndrome
Coronary heart disease
Myocardial infarction
Stable angina
Journal
Clinics (Sao Paulo, Brazil)
ISSN: 1980-5322
Titre abrégé: Clinics (Sao Paulo)
Pays: United States
ID NLM: 101244734
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
03
2023
revised:
15
09
2023
accepted:
26
09
2023
medline:
1
11
2023
pubmed:
19
10
2023
entrez:
18
10
2023
Statut:
epublish
Résumé
Stable angina develops during physical activity or stress, and it is typically an aspect of Coronary Heart Disease (CHD) that can lead to arrhythmia, heart failure and even sudden death. ANRIL, an Antisense Noncoding RNA gene in the INK4 Locus, is associated with multiple disorders including CHD; however, expressional levels of ANRIL in between patients with stable angina and myocardial infarction, one of the acute coronary syndrome, have not been clarified yet. The authors enrolled 62 patients with myocardial infarction and 59 with stable angina before primary percutaneous coronary intervention, as well as 48 healthy volunteers. Their peripheral blood was collected for analysis of ANRIL and cardiac troponin I, a traditional diagnostic index of CHD by real-time PCR. The data showed that ANRIL is a better diagnostic indicator than cardiac troponin I in patients with stable angina and that the levels of ANRIL are higher in patients with stable angina than those with the myocardial infarction. The levels of ANRIL in peripheral plasma could be used as a good biomarker for stable angina.
Identifiants
pubmed: 37852142
pii: S1807-5932(23)00125-4
doi: 10.1016/j.clinsp.2023.100289
pmc: PMC10585623
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
Troponin I
0
RNA, Antisense
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100289Informations de copyright
Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hetian Lei reports financial support was provided by National Natural Science Foundation of China.
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