Dopaminergic denervation and associated MRI microstructural changes in the nigrostriatal projection in early Parkinson's disease patients.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
received:
20
02
2023
accepted:
03
10
2023
medline:
19
10
2023
pubmed:
19
10
2023
entrez:
18
10
2023
Statut:
epublish
Résumé
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and a profound reduction of striatal dopamine are two hallmarks of Parkinson's disease (PD). However, it's unclear whether degeneration starts at the neuronal soma or the striatal presynaptic terminals, and how microstructural degeneration is linked to dopaminergic loss is also uncertain. In this study, thirty de novo PD patients and twenty healthy subjects (HS) underwent 6-[
Identifiants
pubmed: 37852988
doi: 10.1038/s41531-023-00586-x
pii: 10.1038/s41531-023-00586-x
pmc: PMC10584921
doi:
Types de publication
Journal Article
Langues
eng
Pagination
144Informations de copyright
© 2023. Springer Nature Limited.
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