Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 10 2023
18 10 2023
Historique:
received:
31
05
2023
accepted:
12
10
2023
medline:
23
10
2023
pubmed:
19
10
2023
entrez:
18
10
2023
Statut:
epublish
Résumé
The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and inflammatory changes in liver of rats during their fetal development period. Fifty-two Sprague-Dawley pregnant rats were equally divided into control and exposed groups. Whole embryos were removed at 7.5 dpc (days post coitus), while liver tissues were extracted from embryos at 11.5, 15.5, and 19.5 dpc. For exposed animals, results showed an increased OS reflected by high levels of malondialdehyde (MDA), a decrease in cytosolic superoxide dismutase (cytoSOD) activity, in mitochondrial superoxide dismutase (mitoSOD) levels and catalase (CAT) mRNA expression but also in hepatic nuclear factor erythroïd 2-related Factor 2 (Nrf-2), protein kinase B (Akt1), and intercellular adhesion molecule-1 (ICAM-1) mRNA expression at 15.5 dpc. Moreover, GSM-EMR exposure was shown to significantly decrease mitoSOD and CAT activities at almost all studied ages. Thus, rat embryos may be protected by their mothers from OS, apoptotic, and pro-inflammatory responses till a sensitive developmental stage, during a continuous prenatal EMR exposure. This protection could be then created from the embryos themselves.
Identifiants
pubmed: 37853153
doi: 10.1038/s41598-023-44814-z
pii: 10.1038/s41598-023-44814-z
pmc: PMC10584814
doi:
Substances chimiques
Superoxide Dismutase
EC 1.15.1.1
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17806Informations de copyright
© 2023. Springer Nature Limited.
Références
Cell Physiol Biochem. 2019;52(6):1398-1411
pubmed: 31075190
J Indian Assoc Pediatr Surg. 2015 Oct-Dec;20(4):179-83
pubmed: 26628809
PLoS One. 2012;7(8):e42332
pubmed: 22870319
Electromagn Biol Med. 2012 Mar;31(1):57-66
pubmed: 22268709
Basic Clin Neurosci. 2016 Oct;7(4):315-322
pubmed: 27872692
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Nov;31(6):567-71
pubmed: 27215026
Biol Trace Elem Res. 2020 Apr;194(2):368-378
pubmed: 31317470
Oncotarget. 2017 Jan 17;8(3):3773-3780
pubmed: 27980225
Ann Agric Environ Med. 2017 Mar 31;24(1):13-18
pubmed: 28378967
Heliyon. 2022 Dec 17;8(12):e12367
pubmed: 36590500
J Leukoc Biol. 2020 Sep;108(3):787-799
pubmed: 32182390
J Matern Fetal Neonatal Med. 2009 Oct;22(10):867-72
pubmed: 19488955
Oxid Med Cell Longev. 2019 Nov 25;2019:2053149
pubmed: 31885775
Respir Investig. 2020 Jan;58(1):28-35
pubmed: 31704266
J Matern Fetal Neonatal Med. 2014 Dec;27(18):1915-21
pubmed: 24580725
Ann N Y Acad Sci. 2010 Aug;1203:151-9
pubmed: 20716298
Int J Radiat Biol. 2018 Sep;94(9):850-857
pubmed: 29913098
Biomed Pharmacother. 2020 Sep;129:110373
pubmed: 32603894
Nucleic Acids Res. 2016 Jan 4;44(D1):D917-24
pubmed: 26507857
Biomed Pharmacother. 2019 Apr;112:108635
pubmed: 30798126
Toxicol In Vitro. 2021 Apr;72:105106
pubmed: 33539984
Birth Defects Res B Dev Reprod Toxicol. 2010 Apr;89(2):106-15
pubmed: 20127827
Sci Rep. 2018 May 9;8(1):7323
pubmed: 29743626
Biol Trace Elem Res. 2013 Dec;156(1-3):221-9
pubmed: 24101576
J Chem Neuroanat. 2016 Sep;75(Pt B):85-93
pubmed: 26371078
Turk J Med Sci. 2015;45(2):291-7
pubmed: 26084117
J Chem Neuroanat. 2016 Sep;75(Pt B):52-61
pubmed: 26686296
J Chem Neuroanat. 2016 Sep;75(Pt B):62-9
pubmed: 26686295
Free Radic Biol Med. 2014 Jan;66:36-44
pubmed: 23434765
Curr Opin Nephrol Hypertens. 2020 Jan;29(1):128-135
pubmed: 31592832
Int J Environ Res Public Health. 2020 Jan 28;17(3):
pubmed: 32013005
Biochem J. 2016 Dec 15;473(24):4527-4550
pubmed: 27941030
Am J Pathol. 2000 Dec;157(6):2111-22
pubmed: 11106583
Oxid Med Cell Longev. 2018 Nov 8;2018:5076271
pubmed: 30533171
BMC Genomics. 2011 Dec 20;12:616
pubmed: 22185473
Oxid Med Cell Longev. 2012;2012:740280
pubmed: 22778799
Int J Radiat Biol. 2010 Nov;86(11):935-45
pubmed: 20807176
Biotech Histochem. 2015 Feb;90(2):93-101
pubmed: 25158858
J Med Life. 2019 Jul-Sep;12(3):253-259
pubmed: 31666827
Carcinogenesis. 2020 Jun 17;41(4):405-416
pubmed: 32347301
Electromagn Biol Med. 2015;34(4):390-7
pubmed: 25166431
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
J Matern Fetal Neonatal Med. 2017 Oct;30(19):2297-2300
pubmed: 27724130
J Chem Neuroanat. 2016 Sep;75(Pt B):134-9
pubmed: 26520617
Cutan Ocul Toxicol. 2012 Jun;31(2):89-94
pubmed: 22335472
Free Radic Biol Med. 2010 Dec 1;49(11):1603-16
pubmed: 20840865
Molecules. 2020 Sep 26;25(19):
pubmed: 32993187
Jundishapur J Nat Pharm Prod. 2012 Fall;7(4):168-75
pubmed: 24624177
J Microsc Ultrastruct. 2017 Oct-Dec;5(4):167-176
pubmed: 30023251
Neuropharmacology. 2020 May 1;167:107989
pubmed: 32032607
Cell Mol Life Sci. 2016 Sep;73(17):3221-47
pubmed: 27100828
Int J Mol Sci. 2020 Jul 06;21(13):
pubmed: 32640524
Int J Mol Sci. 2015 Nov 02;16(11):26087-124
pubmed: 26540040
Electromagn Biol Med. 2015;34(4):279-84
pubmed: 24712749
Biomol Ther (Seoul). 2019 May 1;27(3):265-275
pubmed: 30481957
Int J Radiat Biol. 2010 Dec;86(12):1088-94
pubmed: 20701462
Environ Pollut. 2022 Jan 1;292(Pt B):118444
pubmed: 34742820
J Trace Elem Med Biol. 2021 Mar;64:126707
pubmed: 33360647
J Microsc Ultrastruct. 2017 Oct-Dec;5(4):216-224
pubmed: 30023257
Bioelectromagnetics. 2021 Jan;42(1):76-85
pubmed: 33368426