Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.

Humans COVID-19 SARS-CoV-2 / metabolism Cathepsins Antiviral Agents / pharmacology Protease Inhibitors / pharmacology Cysteine Endopeptidases / metabolism

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
18 10 2023
Historique:
received: 12 01 2023
accepted: 01 09 2023
medline: 23 10 2023
pubmed: 19 10 2023
entrez: 18 10 2023
Statut: epublish

Résumé

Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (M

Identifiants

DOI: 10.1038/s42003-023-05317-9 PMID: 37853179 PMC: PMC10584882
pubmed: 37853179
doi: 10.1038/s42003-023-05317-9
pii: 10.1038/s42003-023-05317-9
pmc: PMC10584882
doi:

Substances chimiques

calpeptin 18X9FR245W
Cathepsins EC 3.4.-
Antiviral Agents 0
Protease Inhibitors 0
Cysteine Endopeptidases EC 3.4.22.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1058

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Patrick Y A Reinke (PYA)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
ORCID: 0000-0002-7354-0839

Edmarcia Elisa de Souza (EE)

Department of Parasitology, Institute of Biomedical Sciences at the University of São Paulo, São Paulo, Brazil.

Sebastian Günther (S)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
ORCID: 0000-0002-7329-6653

Sven Falke (S)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
ORCID: 0000-0003-3409-1791

Julia Lieske (J)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
ORCID: 0000-0002-5439-5082

Wiebke Ewert (W)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
ORCID: 0000-0001-8626-4864

Jure Loboda (J)

Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.
Jožef Stefan International Postgraduate School, Jamova 39, Ljubljana, Slovenia.
ORCID: 0000-0002-9601-3484

Alexander Herrmann (A)

Institute of Virology, Helmholtz Munich, Munich, Germany.
ORCID: 0000-0002-2749-9003

Aida Rahmani Mashhour (A)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
ORCID: 0000-0001-9177-5589

Katarina Karničar (K)

Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.
Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, Jamova 39, 1000, Ljubljana, Slovenia.
ORCID: 0000-0002-7033-9224

Aleksandra Usenik (A)

Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.
Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, Jamova 39, 1000, Ljubljana, Slovenia.
ORCID: 0000-0003-2366-2886

Nataša Lindič (N)

Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.
ORCID: 0000-0001-7681-3436

Andreja Sekirnik (A)

Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.

Viviane Fongaro Botosso (VF)

Virology Laboratory, Center of Development and Innovation, Butantan Institute, São Paulo, Brazil.
ORCID: 0000-0002-7876-3687

Gláucia Maria Machado Santelli (GMM)

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Josana Kapronezai (J)

Virology Laboratory, Center of Development and Innovation, Butantan Institute, São Paulo, Brazil.
ORCID: 0000-0002-2182-4549

Marcelo Valdemir de Araújo (MV)

Virology Laboratory, Center of Development and Innovation, Butantan Institute, São Paulo, Brazil.
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
ORCID: 0000-0001-9695-3225

Taiana Tainá Silva-Pereira (TT)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.

Antônio Francisco de Souza Filho (AFS)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
ORCID: 0000-0003-4728-1228

Mariana Silva Tavares (MS)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Lizdany Flórez-Álvarez (L)

Department of Parasitology, Institute of Biomedical Sciences at the University of São Paulo, São Paulo, Brazil.

Danielle Bruna Leal de Oliveira (DBL)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
ORCID: 0000-0002-0534-0886

Edison Luiz Durigon (EL)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Paula Roberta Giaretta (PR)

Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, 4474 TAMU, School Station, TX, USA.
ORCID: 0000-0003-2261-281X

Marcos Bryan Heinemann (MB)

Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
ORCID: 0000-0001-6444-9788

Maurice Hauser (M)

Institute for Organic Chemistry and BMWZ, Leibniz University of Hannover, Schneiderberg 38, 30167, Hannover, Germany.

Brandon Seychell (B)

Department of Chemistry, Institute of Physical Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.

Hendrik Böhler (H)

Department of Chemistry, Institute of Physical Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.

Wioletta Rut (W)

Department of Chemical Biology and Bioimaging, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.

Marcin Drag (M)

Department of Chemical Biology and Bioimaging, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.
ORCID: 0000-0001-8510-1967

Tobias Beck (T)

Department of Chemistry, Institute of Physical Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.
Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
ORCID: 0000-0001-7398-3982

Russell Cox (R)

Institute for Organic Chemistry and BMWZ, Leibniz University of Hannover, Schneiderberg 38, 30167, Hannover, Germany.
ORCID: 0000-0002-1844-0157

Henry N Chapman (HN)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Department of Physics, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
ORCID: 0000-0002-4655-1743

Christian Betzel (C)

Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.
Department of Chemistry, Institute of Biochemistry and Molecular Biology and Laboratory for Structural Biology of Infection and Inflammation, c/o DESY, Universität Hamburg, 22607, Hamburg, Germany.
ORCID: 0000-0002-3879-5019

Wolfgang Brehm (W)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.

Winfried Hinrichs (W)

Universität Greifswald, Institute of Biochemistry, Felix-Hausdorff-Str. 4, 17489, Greifswald, Germany.
ORCID: 0000-0002-0435-4565

Gregor Ebert (G)

Institute of Virology, Helmholtz Munich, Munich, Germany.
Institute of Virology, Technical University of Munich, Munich, Germany.
ORCID: 0000-0002-5318-3037

Sharissa L Latham (SL)

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia.
St Vincent's Hospital Clinical School, UNSW, Sydney, NSW, Australia.

Ana Marcia de Sá Guimarães (AMS)

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
ORCID: 0000-0002-8261-5863

Dusan Turk (D)

Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia. dusan.turk@ijs.si.
Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, Jamova 39, 1000, Ljubljana, Slovenia. dusan.turk@ijs.si.
ORCID: 0000-0003-0205-6609

Carsten Wrenger (C)

Department of Parasitology, Institute of Biomedical Sciences at the University of São Paulo, São Paulo, Brazil. cwrenger@icb.usp.br.
ORCID: 0000-0001-5987-1749

Alke Meents (A)

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany. alke.meents@desy.de.
ORCID: 0000-0001-6078-4095

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Calpeptin is a potent cathepsin inhibitor and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Calpeptin is a potent cathepsin inhibitor and...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Calpeptin is a potent cathepsin inhibitor and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Cathepsines › Calpeptin is a potent cathepsin inhibitor and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Calpeptin is a potent cathepsin inhibitor and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Calpeptin is a potent cathepsin inhibitor and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Calpeptin is a potent cathepsin inhibitor and...