Neurochemical Effects of Methylphenidate and Modafinil in Ameliorating Stress-Induced Cognitive Deficits.

Journal

ACS pharmacology & translational science

ISSN: 2575-9108

Titre abrégé: ACS Pharmacol Transl Sci

Pays: United States

ID NLM: 101721411

Informations de publication

Date de publication:
13 Oct 2023

Historique:

received: 07 04 2023

pmc-release: 08 09 2024

medline: 19 10 2023

pubmed: 19 10 2023

entrez: 19 10 2023

Statut: epublish

Résumé

Chronic stressful situations result in altered monoaminergic activity of neurotransmitters, resulting in various conditions characterized by deficits in learning, memory and attention. Stimulant effects can be visualized in terms of increased cognitive abilities through enhancement of dopamine (DA) release. This study examined cognitive responses and brain DA and 5-hydroxytryptamine (5HT) levels after prolonged methylphenidate (MPH) and modafinil administration, to demonstrate their effect on stress-induced cognitive deficits in rats. Effects on cognition were evaluated by passive avoidance and water maze tests. Furthermore brain levels of DA, homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC), 5HT and 5-hydroxyindoleacetic acid (5HIAA) were analyzed by high-performance liquid chromatography coupled with electrochemical detection. We found that both MPH and modafinil improved cognition in both restrained and unrestrained rats, as examined through water maze and passive avoidance tests. Furthermore, these substance were associated with increased brain DA and 5-HT levels. Notabily, we observed decrease in DOPAC and HVA levels, while 5-HIAA levels exhibited a slight increase. The prevention of stress-induced cognitive deficits by MPH and modafinil could be elucidated through the interaction between 5HT and DA in regulating cognitive function.

Identifiants

DOI: 10.1021/acsptsci.3c00077 PMID: 37854618 PMC: PMC10580386

pubmed: 37854618

doi: 10.1021/acsptsci.3c00077

pmc: PMC10580386

doi:

Types de publication

Journal Article

Langues

eng

Pagination

1357-1372

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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