Detection of Minute virus of mice strains in different cell lines: Implications for adventitious agent testing.
Chinese hamster ovary
HEK-293 cells
MVM
detection of adventitious contamination
human embryo kidney
mouse minute virus
Journal
Biotechnology and bioengineering
ISSN: 1097-0290
Titre abrégé: Biotechnol Bioeng
Pays: United States
ID NLM: 7502021
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
revised:
20
09
2023
received:
21
08
2023
accepted:
02
10
2023
pubmed:
19
10
2023
medline:
19
10
2023
entrez:
19
10
2023
Statut:
aheadofprint
Résumé
Minute virus of mice (MMV) has contaminated biotechnological processes in the past and specific MMV testing is therefore recommended, if the production cell line is known to be permissive for this virus. Testing is widely done using cell-culture-based adventitious virus assays, yet MMV strains may differ in their in vitro cell tropism. Here, we investigated the growth characteristics of different MMV strains on A9 and 324K cells and identified significant differences in susceptibility of these widely used indicator cell lines to infection by different strains of MMV, which has implications for MMV detectability during routine testing of biotechnology process harvests. An MMV-specific polymerase chain reaction was evaluated as a more encompassing method and was shown as suitable replacement for cell culture-based detection of the different MMV strains, with the additional benefit that detection is more rapid and can be extended to other rodent parvoviruses that might contaminate biotechnological processes. Although no MMV contamination event of human-derived cell lines has happened in the past, biotechnological processes that are based on these also need to consider MMV-specific testing, as, for example, HEK293, a human-derived cell line commonly used in biopharmaceutical manufacturing, was shown as susceptible to productive MMV infection in the current work.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Takeda Manufacturing Austria AG
Informations de copyright
© 2023 Takeda Manufacturing Austria AG and The Authors. Biotechnology and Bioengineering published by Wiley Periodicals LLC.
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