Hereditary transthyretin amyloidosis in middle-aged and elderly patients with idiopathic polyneuropathy: a nationwide prospective study.
Amyloidosis
TTR gene
epidemiology
neuropathy
transthyretin
Journal
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
ISSN: 1744-2818
Titre abrégé: Amyloid
Pays: England
ID NLM: 9433802
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
medline:
19
10
2023
pubmed:
19
10
2023
entrez:
19
10
2023
Statut:
aheadofprint
Résumé
Hereditary transthyretin amyloidosis (ATTRv) is an adult-onset autosomal dominant disease resulting from In this 5 year-long (2017-2021) nationwide prospective study, we systematically analysed the 553 patients (70% males) with a mean age of 70 years were included. A In this nationwide prospective study, we found ATTRv in 2.7% of patients with age >50 years with a progressive polyneuropathy. These results are highly important for the early identification of patients in need of disease-modifying treatments.
Sections du résumé
BACKGROUND
UNASSIGNED
Hereditary transthyretin amyloidosis (ATTRv) is an adult-onset autosomal dominant disease resulting from
METHODS
UNASSIGNED
In this 5 year-long (2017-2021) nationwide prospective study, we systematically analysed the
RESULTS
UNASSIGNED
553 patients (70% males) with a mean age of 70 years were included. A
CONCLUSION
UNASSIGNED
In this nationwide prospective study, we found ATTRv in 2.7% of patients with age >50 years with a progressive polyneuropathy. These results are highly important for the early identification of patients in need of disease-modifying treatments.
Identifiants
pubmed: 37855400
doi: 10.1080/13506129.2023.2270661
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM