A third of the radiotracer dose: two decades of progress in pediatric [
Pediatrics
Positron emission tomography
Radiation dose
Radioactive tracers
[18F]fluorodeoxyglucose
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
received:
14
04
2023
accepted:
18
08
2023
revised:
11
08
2023
pubmed:
19
10
2023
medline:
19
10
2023
entrez:
19
10
2023
Statut:
aheadofprint
Résumé
To assess the evolution of administered radiotracer activity for F-18-fluorodeoxyglucose (18F-FDG) PET/CT or PET/MR in pediatric patients (0-16 years) between years 2000 and 2021. Pediatric patients (≤ 16 years) referred for 18F-FDG PET/CT or PET/MR imaging of the body during 2000 and 2021 were retrospectively included. The amount of administered radiotracer activity in megabecquerel (MBq) was recorded, and signal-to-noise ratio (SNR) was measured in the right liver lobe with a 4 cm Two hundred forty-three children and adolescents underwent a total of 466 examinations. The median injected 18F-FDG activity in MBq decreased significantly from 296 MBq in 2000-2005 to 100 MBq in 2016-2021 (p < 0.001), equaling approximately one-third of the initial amount. The median SNR ratio was stable during all years with 11.7 (interquartile range [IQR] 10.7-12.9, p = 0.133). Children have benefited from a massive reduction in the administered 18F-FDG dose over the past 20 years without compromising objective image quality. Radiotracer dose was reduced considerably over the past two decades of pediatric F-18-fluorodeoxyglucose PET/CT and PET/MR imaging highlighting the success of technical innovations in pediatric PET imaging. • The evolution of administered radiotracer activity for F-18-fluorodeoxyglucose (18F-FDG) PET/CT or PET/MR in pediatric patients (0-16 years) between 2000 and 2021 was assessed. • The injected tracer activity decreased by 66% during the study period from 296 megabecquerel (MBq) to 100 MBq (p < 0.001). • The continuous implementation of technical innovations in pediatric hybrid 18F-FDG PET has led to a steady decrease in the amount of applied radiotracer, which is particularly beneficial for children who are more sensitive to radiation.
Identifiants
pubmed: 37855853
doi: 10.1007/s00330-023-10319-6
pii: 10.1007/s00330-023-10319-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023. The Author(s).
Références
Freebody J, Wegner EA, Rossleigh MA (2014) 2-Deoxy-2-((18)F)fluoro-D-glucose positron emission tomography/computed tomography imaging in paediatric oncology. World J Radiol 6:741–755
doi: 10.4329/wjr.v6.i10.741
Harrison DJ, Parisi MT, Shulkin BL (2017) The role of (18)F-FDG-PET/CT in pediatric sarcoma. Semin Nucl Med 47:229–241
doi: 10.1053/j.semnuclmed.2016.12.004
Kluge R, Kurch L, Georgi T, Metzger M (2017) Current role of FDG-PET in pediatric Hodgkin’s lymphoma. Semin Nucl Med 47:242–257
doi: 10.1053/j.semnuclmed.2017.01.001
Uslu L, Donig J, Link M, Rosenberg J, Quon A, Daldrup-Link HE (2015) Value of 18F-FDG PET and PET/CT for evaluation of pediatric malignancies. J Nucl Med 56:274–286
doi: 10.2967/jnumed.114.146290
Gungor T, Engel-Bicik I, Eich G et al (2001) Diagnostic and therapeutic impact of whole body positron emission tomography using fluorine-18-fluoro-2-deoxy-D-glucose in children with chronic granulomatous disease. Arch Dis Child 85:341–345
doi: 10.1136/adc.85.4.341
Garg G, DaSilva R, Bhalakia A, Milstein DM (2016) Utility of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in a child with chronic granulomatous disease. Indian J Nucl Med 31:62–64
doi: 10.4103/0972-3919.172366
Theobald I, Fischbach R, Hulskamp G et al (2002) Pulmonary aspergillosis as initial manifestation of septic granulomatosis (chronic granulomatous disease, CGD) in a premature monozygotic female twin and FDG-PET diagnosis of spread of the disease. Radiologe 42:42–45
doi: 10.1007/s117-002-8116-0
Meller J, Sahlmann CO, Scheel AK (2007) 18F-FDG PET and PET/CT in fever of unknown origin. J Nucl Med 48:35–45
Baum SH, Fruhwald M, Rahbar K, Wessling J, Schober O, Weckesser M (2011) Contribution of PET/CT to prediction of outcome in children and young adults with rhabdomyosarcoma. J Nucl Med 52:1535–1540
doi: 10.2967/jnumed.110.082511
Ricard F, Cimarelli S, Deshayes E, Mognetti T, Thiesse P, Giammarile F (2011) Additional benefit of F-18 FDG PET/CT in the staging and follow-up of pediatric rhabdomyosarcoma. Clin Nucl Med 36:672–677
doi: 10.1097/RLU.0b013e318217ae2e
London K, Stege C, Cross S et al (2012) 18F-FDG PET/CT compared to conventional imaging modalities in pediatric primary bone tumors. Pediatr Radiol 42:418–430
doi: 10.1007/s00247-011-2278-x
Boktor RR, Omar WS, Mousa E et al (2012) A preliminary report on the impact of (1)(8)F-FDG PET/CT in the management of paediatric head and neck cancer. Nucl Med Commun 33:21–28
doi: 10.1097/MNM.0b013e32834c3ebe
Halalsheh H, Kaste SC, Navid F et al (2018) The role of routine imaging in pediatric cutaneous melanoma. Pediatr Blood Cancer 65:e27412
doi: 10.1002/pbc.27412
Daldrup-Link HE, Theruvath AJ, Baratto L, Hawk KE (2021) One-stop local and whole-body staging of children with cancer. Pediatr Radiol. https://doi.org/10.1007/s00247-021-05076-x
doi: 10.1007/s00247-021-05076-x
Biassoni L, Easty M (2017) Paediatric nuclear medicine imaging. Br Med Bull 123:127–148
doi: 10.1093/bmb/ldx025
Cheng G, Servaes S, Zhuang H (2013) Value of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scan versus diagnostic contrast computed tomography in initial staging of pediatric patients with lymphoma. Leuk Lymphoma 54:737–742
doi: 10.3109/10428194.2012.727416
Jadvar H, Connolly LP, Fahey FH, Shulkin BL (2007) PET and PET/CT in pediatric oncology. Semin Nucl Med 37:316–331
doi: 10.1053/j.semnuclmed.2007.04.001
London K, Cross S, Onikul E, Dalla-Pozza L, Howman-Giles R (2011) 18F-FDG PET/CT in paediatric lymphoma: comparison with conventional imaging. Eur J Nucl Med Mol Imaging 38:274–284
doi: 10.1007/s00259-010-1619-6
Colleran GC, Kwatra N, Oberg L et al (2017) How we read pediatric PET/CT: indications and strategies for image acquisition, interpretation and reporting. Cancer Imaging 17:28
doi: 10.1186/s40644-017-0130-8
Foucault A, Ancelet S, Dreuil S et al (2022) Childhood cancer risks estimates following CT scans: an update of the French CT cohort study. Eur Radiol 32:5491–5498
doi: 10.1007/s00330-022-08602-z
Kutanzi KR, Lumen A, Koturbash I, Miousse IR (2016) Pediatric exposures to ionizing radiation: carcinogenic considerations. Int J Environ Res Public Health 13(11):1057. https://doi.org/10.3390/ijerph13111057
Mathews JD, Forsythe AV, Brady Z et al (2013) Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ 346:f2360
doi: 10.1136/bmj.f2360
Nikkila A, Raitanen J, Lohi O, Auvinen A (2018) Radiation exposure from computerized tomography and risk of childhood leukemia: Finnish register-based case-control study of childhood leukemia (FRECCLE). Haematologica 103:1873–1880
doi: 10.3324/haematol.2018.187716
Pearce MS, Salotti JA, Little MP et al (2012) Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380:499–505
doi: 10.1016/S0140-6736(12)60815-0
Chawla SC, Federman N, Zhang D et al (2010) Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review. Pediatr Radiol 40:681–686
doi: 10.1007/s00247-009-1434-z
Nievelstein RA, Quarles van Ufford HM, Kwee TC et al (2012) Radiation exposure and mortality risk from CT and PET imaging of patients with malignant lymphoma. Eur Radiol 22:1946–1954
doi: 10.1007/s00330-012-2447-9
Schafer JF, Gatidis S, Schmidt H et al (2014) Simultaneous whole-body PET/MR imaging in comparison to PET/CT in pediatric oncology: initial results. Radiology 273:220–231
doi: 10.1148/radiol.14131732
Gatidis S, Schmidt H, Gucke B et al (2016) Comprehensive oncologic imaging in infants and preschool children with substantially reduced radiation exposure using combined simultaneous (1)(8)F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging: a direct comparison to (1)(8)F-fluorodeoxyglucose positron emission tomography/computed tomography. Invest Radiol 51:7–14
doi: 10.1097/RLI.0000000000000200
Gatidis S, Bender B, Reimold M, Schafer JF (2017) PET/MRI in children. Eur J Radiol 94:A64–A70
doi: 10.1016/j.ejrad.2017.01.018
Treves ST, Gelfand MJ, Fahey FH, Parisi MT (2016) 2016 Update of the North American Consensus Guidelines for Pediatric Administered Radiopharmaceutical Activities. J Nucl Med 57:15N-18N
Lassmann M, Treves ST (2014) Pediatric Radiopharmaceutical Administration: harmonization of the 2007 EANM Paediatric Dosage Card (Version 1.5.2008) and the 2010 North American Consensus guideline. Eur J Nucl Med Mol Imaging 41:1636
doi: 10.1007/s00259-014-2817-4
Sah BR, Stolzmann P, Delso G et al (2017) Clinical evaluation of a block sequential regularized expectation maximization reconstruction algorithm in 18F-FDG PET/CT studies. Nucl Med Commun 38:57–66
doi: 10.1097/MNM.0000000000000604
Vandenberghe S, D’Asseler Y, Van de Walle R et al (2001) Iterative reconstruction algorithms in nuclear medicine. Comput Med Imaging Graph 25:105–111
doi: 10.1016/S0895-6111(00)00060-4
Riddell C, Carson RE, Carrasquillo JA et al (2001) Noise reduction in oncology FDG PET images by iterative reconstruction: a quantitative assessment. J Nucl Med 42:1316–1323
Gong K, Kim K, Cui J, Wu D, Li Q (2021) The evolution of image reconstruction in PET: from filtered back-projection to artificial intelligence. PET Clin 16:533–542
doi: 10.1016/j.cpet.2021.06.004
(2021) R: A language and environment for statistical computing. Vienna, Austria. Version 4.1.1, https://www.rproject.org
Brenner DJ, Doll R, Goodhead DT et al (2003) Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proc Natl Acad Sci U S A 100:13761–13766
doi: 10.1073/pnas.2235592100
Lassmann M, Biassoni L, Monsieurs M et al (2007) The new EANM paediatric dosage card. Eur J Nucl Med Mol Imaging 34:796–798
doi: 10.1007/s00259-007-0370-0
Lassmann M, Biassoni L, Monsieurs M et al (2008) The new EANM paediatric dosage card. Eur J Nucl Med Mol Imaging 35:1748
doi: 10.1007/s00259-007-0572-5
Marcassa C, Zoccarato O, Calza P, Campini R (2013) Temporal evolution of administered activity in cardiac gated SPECT and patients’ effective dose: analysis of an historical series. Eur J Nucl Med Mol Imaging 40:325–330
doi: 10.1007/s00259-012-2287-5
Cox CPW, van Assema DME, Verburg FA, Brabander T, Konijnenberg M, Segbers M (2021) A dedicated paediatric [(18)F]FDG PET/CT dosage regimen. EJNMMI Res 11:65
doi: 10.1186/s13550-021-00812-8
Jones T, Townsend D (2017) History and future technical innovation in positron emission tomography. J Med Imaging (Bellingham) 4:011013
doi: 10.1117/1.JMI.4.1.011013
Nardo L, Schmall JP, Werner TJ, Malogolowkin M, Badawi RD, Alavi A (2020) Potential roles of total-body PET/computed tomography in pediatric imaging. PET Clin 15:271–279
doi: 10.1016/j.cpet.2020.03.009