Syncytin-1, syncytin-2 and suppressyn in human health and disease.

Pregnancy Female Humans Placenta Gene Products, env / genetics Pregnancy Proteins / genetics Endogenous Retroviruses Pre-Eclampsia
Gestational trophoblastic disease HERVs Preeclampsia Suppressyn Syncytin-1 Syncytin-2

Journal

Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 24 03 2023
accepted: 09 10 2023
revised: 06 10 2023
medline: 6 12 2023
pubmed: 19 10 2023
entrez: 19 10 2023
Statut: ppublish

Résumé

In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products-syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described.

Identifiants

DOI: 10.1007/s00109-023-02385-6 PMID: 37855856 PMC: PMC10697888
pubmed: 37855856
doi: 10.1007/s00109-023-02385-6
pii: 10.1007/s00109-023-02385-6
pmc: PMC10697888
doi:

Substances chimiques

syncytin 0
Gene Products, env 0
Pregnancy Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1527-1542

Subventions

Organisme : Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR (SK)
ID : VEGA 1/0559/22

Informations de copyright

© 2023. The Author(s).

Références

Clin Chim Acta. 2018 Aug;483:265-270
pubmed: 29750965
Placenta. 2022 Apr;121:155-163
pubmed: 35349915
J Virol. 2015 Apr;89(8):4047-50
pubmed: 25653437
Placenta. 2001 Nov;22(10):808-12
pubmed: 11718567
Cell Mol Life Sci. 2022 May 10;79(6):290
pubmed: 35536515
Viruses. 2023 Jan 18;15(2):
pubmed: 36851488
J Hypertens. 2010 Jul;28(7):1349-55
pubmed: 20467325
ScientificWorldJournal. 2007 Aug 17;7:1193-7
pubmed: 17704852
Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17532-7
pubmed: 18988732
Prog Mol Biol Transl Sci. 2017;145:111-162
pubmed: 28110749
Mol Cell Biol. 2003 May;23(10):3566-74
pubmed: 12724415
Placenta. 2016 Oct;46:18-25
pubmed: 27697217
Pharmaceuticals (Basel). 2021 Jan 16;14(1):
pubmed: 33467098
J Clin Endocrinol Metab. 2017 Sep 1;102(9):3182-3194
pubmed: 28531338
J Immunol. 2007 Jul 15;179(2):1210-24
pubmed: 17617614
Genomics. 2004 Dec;84(6):982-90
pubmed: 15533715
PLoS Genet. 2013 Mar;9(3):e1003400
pubmed: 23555306
Cell Mol Immunol. 2021 Nov;18(11):2566-2568
pubmed: 34645941
J Mol Biol. 2009 Sep 18;392(2):301-18
pubmed: 19616006
Environ Int. 2022 Nov;169:107502
pubmed: 36095930
BJOG. 2006 Feb;113(2):152-8
pubmed: 16411991
EBioMedicine. 2021 Apr;66:103341
pubmed: 33867312
N Engl J Med. 2017 Aug 17;377(7):613-622
pubmed: 28657417
Lancet. 1991 Apr 6;337(8745):862-3
pubmed: 1707471
J Reprod Immunol. 2021 Nov;148:103428
pubmed: 34601377
Nature. 2000 Feb 17;403(6771):785-9
pubmed: 10693809
FASEB J. 2014 Aug;28(8):3703-19
pubmed: 24812088
Hum Reprod Update. 2004 Nov-Dec;10(6):487-96
pubmed: 15333590
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):725-30
pubmed: 15644441
Biol Reprod. 2020 Feb 12;102(1):185-198
pubmed: 31318021
Retrovirology. 2004 Oct 11;1:32
pubmed: 15476554
Apoptosis. 2007 Jan;12(1):37-43
pubmed: 17080327
Onco Targets Ther. 2018 Dec 17;12:31-40
pubmed: 30588028
Reprod Sci. 2011 Nov;18(11):1085-91
pubmed: 21493955
Front Cell Dev Biol. 2022 Apr 12;10:852561
pubmed: 35493107
J Virol. 2003 Oct;77(19):10414-22
pubmed: 12970426
Cell Death Discov. 2021 Jul 8;7(1):177
pubmed: 34238921
Arch Virol. 2003 Apr;148(4):659-75
pubmed: 12664292
Placenta. 2007 Feb-Mar;28(2-3):185-91
pubmed: 16714059
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2184-5
pubmed: 22308481
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20534-9
pubmed: 18077339
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E487-96
pubmed: 25605903
Placenta. 2012 Nov;33(11):933-41
pubmed: 22999499
Sci Rep. 2019 Dec 20;9(1):19502
pubmed: 31862915
Front Psychiatry. 2018 Sep 07;9:422
pubmed: 30245643
Front Cell Dev Biol. 2020 Jun 03;8:402
pubmed: 32582698
Cell Signal. 2013 Apr;25(4):1027-35
pubmed: 23333240
Science. 2022 Oct 28;378(6618):422-428
pubmed: 36302021
Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120507
pubmed: 23938756
Int J Gen Med. 2021 Mar 19;14:957-965
pubmed: 33776474
J Virol Methods. 2009 Oct;161(1):98-106
pubmed: 19505508
Drug Saf. 2020 Dec;43(12):1287-1296
pubmed: 32794123
PLoS One. 2014 Feb 21;9(2):e89563
pubmed: 24586874
Bone. 2011 Apr 1;48(4):837-46
pubmed: 21111077
Curr Pharm Des. 2014;20(11):1796-802
pubmed: 23888950
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Am J Obstet Gynecol. 2002 Feb;186(2):210-3
pubmed: 11854637
Cytogenet Genome Res. 2005;110(1-4):353-64
pubmed: 16093687
Cell Rep. 2017 Oct 31;21(5):1150-1159
pubmed: 29091755
Cell Mol Life Sci. 2006 Aug;63(16):1906-11
pubmed: 16871371
J Assist Reprod Genet. 2014 May;31(5):533-9
pubmed: 24687878
Sci Rep. 2022 Jun 22;12(1):10552
pubmed: 35732788
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13013-8
pubmed: 14557543
PLoS Biol. 2022 May 24;20(5):e3001506
pubmed: 35609110
Front Microbiol. 2018 Mar 14;9:462
pubmed: 29593697
Sci Rep. 2020 Apr 14;10(1):6398
pubmed: 32286341
Placenta. 2012 Jun;33(6):460-6
pubmed: 22381536
Viruses. 2014 Nov 24;6(11):4609-27
pubmed: 25421890
Mult Scler. 2022 Mar;28(3):429-440
pubmed: 34240656
Annu Rev Neurosci. 2008;31:247-69
pubmed: 18558855
J Infect Dev Ctries. 2015 Jul 04;9(6):577-87
pubmed: 26142666
Rambam Maimonides Med J. 2022 Jan 27;13(1):
pubmed: 35089126
Sci Rep. 2013;3:1462
pubmed: 23492904
Int J Mol Sci. 2021 Sep 23;22(19):
pubmed: 34638599
Biochem Biophys Res Commun. 2005 Jun 17;331(4):1193-200
pubmed: 15883002
Placenta. 2016 Mar;39:116-24
pubmed: 26992684
J Mol Cell Biol. 2019 Dec 23;11(11):967-978
pubmed: 31408157
Histol Histopathol. 2016 Sep;31(9):1037-47
pubmed: 26875564
Front Oncol. 2021 Jul 07;11:692142
pubmed: 34307156
Mol Cell Biol. 2012 Sep;32(18):3707-17
pubmed: 22778138
PLoS One. 2013;8(2):e56145
pubmed: 23457515
Andrology. 2022 Jan;10(1):8-10
pubmed: 34411453
Infect Dis Rep. 2022 Mar 11;14(2):184-197
pubmed: 35314653
Sci Adv. 2021 Jul 28;7(31):
pubmed: 34321199
J Virol. 2001 Dec;75(23):11709-19
pubmed: 11689652
Nature. 2001 Feb 15;409(6822):860-921
pubmed: 11237011
AJP Rep. 2018 Jan;8(1):e18-e24
pubmed: 29472990
Cell Mol Life Sci. 2008 Nov;65(21):3366-82
pubmed: 18818873
Curr Opin Virol. 2017 Aug;25:105-112
pubmed: 28837888
N Engl J Med. 2000 Sep 28;343(13):938-52
pubmed: 11006371
PLoS One. 2015 Jul 08;10(7):e0132099
pubmed: 26154387
J Reprod Immunol. 2023 Feb;155:103784
pubmed: 36508844
Reproduction. 2016 Nov;152(5):R167-78
pubmed: 27486264
Cell Rep. 2020 Mar 31;30(13):4528-4539.e4
pubmed: 32234485
J Virol. 2000 Apr;74(7):3321-9
pubmed: 10708449
Placenta. 2008 Mar;29(3):282-9
pubmed: 18158183
Retrovirology. 2017 Mar 17;14(1):20
pubmed: 28302141

Auteurs

Petra Priščáková (P)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Sasinkova 4, Bratislava, 811 08, Slovak Republic.

Michal Svoboda (M)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Sasinkova 4, Bratislava, 811 08, Slovak Republic.

Zuzana Feketová (Z)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Sasinkova 4, Bratislava, 811 08, Slovak Republic.

Juraj Hutník (J)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Sasinkova 4, Bratislava, 811 08, Slovak Republic.

Vanda Repiská (V)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Sasinkova 4, Bratislava, 811 08, Slovak Republic.

Helena Gbelcová (H)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Sasinkova 4, Bratislava, 811 08, Slovak Republic.

Lajos Gergely (L)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Sasinkova 4, Bratislava, 811 08, Slovak Republic. lajos.gergely@fmed.uniba.sk.
ORCID: 0000-0003-3407-7914

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Syncytin-1, syncytin-2 and suppressyn in human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Syncytin-1, syncytin-2 and suppressyn in human...
questionsmedicales.fr › Structures de l'embryon › Placenta › Syncytin-1, syncytin-2 and suppressyn in human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Produits du gène env › Syncytin-1, syncytin-2 and suppressyn in human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de la grossesse › Syncytin-1, syncytin-2 and suppressyn in human...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › Rétroéléments › Rétrovirus endogènes › Syncytin-1, syncytin-2 and suppressyn in human...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Pré-éclampsie › Syncytin-1, syncytin-2 and suppressyn in human...