Non-invasive temporal interference electrical stimulation of the human hippocampus.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
30
10
2022
accepted:
06
09
2023
medline:
3
11
2023
pubmed:
20
10
2023
entrez:
19
10
2023
Statut:
ppublish
Résumé
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.
Identifiants
pubmed: 37857775
doi: 10.1038/s41593-023-01456-8
pii: 10.1038/s41593-023-01456-8
pmc: PMC10620081
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1994-2004Subventions
Organisme : NIA NIH HHS
ID : R01 AG059089
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG076708
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117063
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG072233
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
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