Fibroblast growth factor 2.
Journal
Differentiation; research in biological diversity
ISSN: 1432-0436
Titre abrégé: Differentiation
Pays: England
ID NLM: 0401650
Informations de publication
Date de publication:
12 Oct 2023
12 Oct 2023
Historique:
received:
22
05
2023
revised:
20
09
2023
accepted:
05
10
2023
medline:
20
10
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
aheadofprint
Résumé
Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from alternative translation initiation events and exhibit unique molecular and cellular functions. In this concise review, we aim to provide an overview of what is currently known about the structure, expression, and functions of the FGF2 isoforms within the contexts of development, homeostasis, and disease.
Identifiants
pubmed: 37858405
pii: S0301-4681(23)00072-5
doi: 10.1016/j.diff.2023.10.001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.