Infection burden and its association with neurite orientation dispersion and density imaging markers in the UK Biobank.
Aging
Brain magnetic resonance imaging
Infection
NODDI
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
05
06
2023
revised:
15
09
2023
accepted:
14
10
2023
pubmed:
20
10
2023
medline:
20
10
2023
entrez:
20
10
2023
Statut:
ppublish
Résumé
Infection burden (IB), although linked to neurodegeneration, including Alzheimer's Disease (AD), has not been examined against neurite orientation, dispersion, and density imaging (NODDI) measures. Among 38,803 UK Biobank adults (Age:40-70 years), we tested associations of total IB (IB Total and hospital-treated infection burdens (IB Total and hospital-treated infections were associated with poorer white matter microstructure (higher ISOVF or OD or lower ICVF), with some heterogeneity across cardiovascular health and AD risk. Longitudinal studies with multiple repeats on neuroimaging markers in comparable samples are needed.
Sections du résumé
BACKGROUND
BACKGROUND
Infection burden (IB), although linked to neurodegeneration, including Alzheimer's Disease (AD), has not been examined against neurite orientation, dispersion, and density imaging (NODDI) measures.
METHODS
METHODS
Among 38,803 UK Biobank adults (Age:40-70 years), we tested associations of total IB (IB
RESULTS
RESULTS
Total and hospital-treated infection burdens (IB
CONCLUSIONS
CONCLUSIONS
Total and hospital-treated infections were associated with poorer white matter microstructure (higher ISOVF or OD or lower ICVF), with some heterogeneity across cardiovascular health and AD risk. Longitudinal studies with multiple repeats on neuroimaging markers in comparable samples are needed.
Identifiants
pubmed: 37858740
pii: S0889-1591(23)00309-4
doi: 10.1016/j.bbi.2023.10.009
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
394-405Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.