Malaria sporozoites evade host complement attack.
C3b
complement
factor H
immune response
immunity
malaria
sporozoite
Journal
Parasite immunology
ISSN: 1365-3024
Titre abrégé: Parasite Immunol
Pays: England
ID NLM: 7910948
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
revised:
04
09
2023
received:
27
02
2023
accepted:
19
09
2023
medline:
20
10
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
aheadofprint
Résumé
Complement is the first line of the host innate immune response against bacterial and viral infections; however, its role in the development of the malaria liver stage remains undefined. We found that sporozoite infection by either a mosquito bite or intravenous injection activated systemic complement, but neither depletion of C3 nor knockout of C3 had a significant effect on malaria liver stage development. Incubation of mouse serum with trypsin-treated sporozoites, but not naive sporozoites, led to the deposition of a membrane attack complex (MAC) on the surface of sporozoites and greatly reduced the number of exo-erythrocytic forms (EEF). Further studies have shown that the recruitment of complement H factor (CFH) may be associated with the prevention of MAC deposition on the surface of naïve sporozoites. Our data strongly suggest that sporozoites can escape complement attacks and provide us with a novel strategy to prevent malaria infection.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13012Subventions
Organisme : State Key Program of the National Natural Science Foundation of China
ID : 81830067
Organisme : National Natural Science Foundation of China
ID : 81802033
Organisme : Natural Science Foundation of Chongqing, China
ID : cstc2018jcyjAX0443
Informations de copyright
© 2023 John Wiley & Sons Ltd.
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