Mapping of the supplementary motor area using repetitive navigated transcranial magnetic stimulation.
TMS
brain mapping
motor function
preoperative diagnostic
supplementary motor area
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
08
07
2023
accepted:
18
09
2023
medline:
20
10
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
epublish
Résumé
The supplementary motor area (SMA) is important for motor and language function. Damage to the SMA may harm these functions, yet tools for a preoperative assessment of the area are still sparse. The aim of this study was to validate a mapping protocol using repetitive navigated transcranial magnetic stimulation (rnTMS) and extend this protocol for both hemispheres and lower extremities. To this purpose, the SMA of both hemispheres were mapped based on a finger tapping task for 30 healthy subjects (35.97 ± 15.11, range 21-67 years; 14 females) using rnTMS at 20 Hz (120% resting motor threshold (RMT)) while controlling for primary motor cortex activation. Points with induced errors were marked on the corresponding MRI. Next, on the identified SMA hotspot a bimanual finger tapping task and the Nine-Hole Peg Test (NHPT) were performed. Further, the lower extremity was mapped at 20 Hz (140%RMT) using a toe tapping task. Mean finger tapping scores decreased significantly during stimulation (25.70taps) compared to baseline (30.48; The current study validated and extended a rnTMS based protocol for the mapping of the SMA regarding motor function of upper and lower extremity. This protocol could be beneficial to better understand functional SMA organisation and improve preoperative planning in patients with SMA lesions.
Sections du résumé
Background
UNASSIGNED
The supplementary motor area (SMA) is important for motor and language function. Damage to the SMA may harm these functions, yet tools for a preoperative assessment of the area are still sparse.
Objective
UNASSIGNED
The aim of this study was to validate a mapping protocol using repetitive navigated transcranial magnetic stimulation (rnTMS) and extend this protocol for both hemispheres and lower extremities.
Methods
UNASSIGNED
To this purpose, the SMA of both hemispheres were mapped based on a finger tapping task for 30 healthy subjects (35.97 ± 15.11, range 21-67 years; 14 females) using rnTMS at 20 Hz (120% resting motor threshold (RMT)) while controlling for primary motor cortex activation. Points with induced errors were marked on the corresponding MRI. Next, on the identified SMA hotspot a bimanual finger tapping task and the Nine-Hole Peg Test (NHPT) were performed. Further, the lower extremity was mapped at 20 Hz (140%RMT) using a toe tapping task.
Results
UNASSIGNED
Mean finger tapping scores decreased significantly during stimulation (25.70taps) compared to baseline (30.48;
Conclusion
UNASSIGNED
The current study validated and extended a rnTMS based protocol for the mapping of the SMA regarding motor function of upper and lower extremity. This protocol could be beneficial to better understand functional SMA organisation and improve preoperative planning in patients with SMA lesions.
Identifiants
pubmed: 37859763
doi: 10.3389/fnins.2023.1255209
pmc: PMC10582562
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1255209Informations de copyright
Copyright © 2023 Kern, Kempter, Picht and Engelhardt.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Hum Brain Mapp. 2019 May;40(7):2125-2142
pubmed: 30653778
Neurosci Lett. 2002 Aug 9;328(2):89-92
pubmed: 12133562
Cortex. 2021 Jan;134:134-144
pubmed: 33278681
J Neurol Surg A Cent Eur Neurosurg. 2020 Mar;81(2):147-154
pubmed: 32045942
J Clin Neurophysiol. 2020 Mar;37(2):140-149
pubmed: 30334832
J Neurosurg. 2022 Dec 2;:1-10
pubmed: 36461815
Acta Neurochir (Wien). 2019 Sep;161(9):1845-1851
pubmed: 31286238
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18565-70
pubmed: 23086164
Neurology. 2004 Apr 27;62(8):1323-32
pubmed: 15111669
J Neural Eng. 2022 Dec 16;19(6):
pubmed: 36541458
Neurosurg Rev. 2022 Feb;45(1):81-90
pubmed: 33993354
J Neurol Sci. 1977 Dec;34(3):301-14
pubmed: 591992
Neurosurgery. 2002 Feb;50(2):297-303; discussion 303-5
pubmed: 11844264
Somatosens Mot Res. 2012;29(2):52-61
pubmed: 22524266
Front Neurosci. 2023 Jun 02;17:1185483
pubmed: 37332876
J Neurosurg. 2017 Apr;126(4):1181-1190
pubmed: 27315027
Nat Rev Neurosci. 2008 Nov;9(11):856-69
pubmed: 18843271
Sci Rep. 2019 Nov 28;9(1):17744
pubmed: 31780823
Neurol Med Chir (Tokyo). 2014;54(7):511-20
pubmed: 24305024
Magn Reson Imaging. 2009 Jul;27(6):733-40
pubmed: 19110394
J Neurosurg. 1996 Oct;85(4):542-9
pubmed: 8814153
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Br J Neurosurg. 2000 Jun;14(3):204-10
pubmed: 10912196
AJNR Am J Neuroradiol. 2018 Aug;39(8):1493-1498
pubmed: 30002054
Eur J Neurosci. 1998 Jun;10(6):2199-203
pubmed: 9753106
Neurosurg Focus. 2018 Jun;44(6):E3
pubmed: 29852764