Clinical hypoxemia score for outpatient child pneumonia care lacking pulse oximetry in Africa and South Asia.
clinical decision rules
hypoxia
low-income countries
pediatrics
primary health care
respiratory tract infection (RTI)
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
06
2023
accepted:
07
09
2023
medline:
20
10
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
epublish
Résumé
Pulse oximeters are not routinely available in outpatient clinics in low- and middle-income countries. We derived clinical scores to identify hypoxemic child pneumonia. This was a retrospective pooled analysis of two outpatient datasets of 3-35 month olds with World Health Organization (WHO)-defined pneumonia in Bangladesh and Malawi. We constructed, internally validated, and compared fit & discrimination of four models predicting SpO 12,712 observations were included. The independent and composite LASSO models discriminated moderately (both C-statistic 0.77) between children with a SpO In the absence of pulse oximeters, both LASSO models better identified outpatient hypoxemic pneumonia cases than the WHO guidelines. Score external validation and implementation are needed.
Sections du résumé
Background
Pulse oximeters are not routinely available in outpatient clinics in low- and middle-income countries. We derived clinical scores to identify hypoxemic child pneumonia.
Methods
This was a retrospective pooled analysis of two outpatient datasets of 3-35 month olds with World Health Organization (WHO)-defined pneumonia in Bangladesh and Malawi. We constructed, internally validated, and compared fit & discrimination of four models predicting SpO
Results
12,712 observations were included. The independent and composite LASSO models discriminated moderately (both C-statistic 0.77) between children with a SpO
Conclusions
In the absence of pulse oximeters, both LASSO models better identified outpatient hypoxemic pneumonia cases than the WHO guidelines. Score external validation and implementation are needed.
Identifiants
pubmed: 37859772
doi: 10.3389/fped.2023.1233532
pmc: PMC10582699
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1233532Subventions
Organisme : FIC NIH HHS
ID : D43 TW012274
Pays : United States
Informations de copyright
© 2023 Schuh, Hooli, Ahmed, King, Roy, Lufesi, Islam, Mvalo, Chowdhury, Ginsburg, Colbourn, Checkley, Baqui and McCollum.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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