Cross-species analysis of differential transcript usage in humans and chickens with fatty liver disease.
cross-species biomarkers
differential gene expression
differential transcript usage
fat metabolism
fatty liver disease
lipidosis
transcript isoforms
Journal
Veterinary world
ISSN: 0972-8988
Titre abrégé: Vet World
Pays: India
ID NLM: 101504872
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
23
05
2023
accepted:
30
08
2023
medline:
20
10
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
ppublish
Résumé
Fatty liver disease is a common condition, characterized by excess fat accumulation in the liver. It can contribute to more severe liver-related health issues, making it a critical concern in avian and human medicine. Apart from modifying the gene expression of liver cells, the disease also alters the expression of specific transcript isoforms, which might serve as new biological markers for both species. This study aimed to identify cross-species genes displaying differential expressions in their transcript isoforms in humans and chickens with fatty liver disease. We performed differential gene expression and differential transcript usage (DTU) analyses on messenger RNA datasets from the livers of both chickens and humans with fatty liver disease. Using appropriate cross-species gene identification methods, we reviewed the acquired candidate genes and their transcript isoforms to determine their potential role in fatty liver disease's pathogenesis. We identified seven genes - This study successfully identified novel human-chicken DTU genes in fatty liver disease. Further research is encouraged to verify the functions and regulations of these transcript isoforms as potential diagnostic markers for fatty liver disease in humans and chickens.
Sections du résumé
Background and Aim
UNASSIGNED
Fatty liver disease is a common condition, characterized by excess fat accumulation in the liver. It can contribute to more severe liver-related health issues, making it a critical concern in avian and human medicine. Apart from modifying the gene expression of liver cells, the disease also alters the expression of specific transcript isoforms, which might serve as new biological markers for both species. This study aimed to identify cross-species genes displaying differential expressions in their transcript isoforms in humans and chickens with fatty liver disease.
Materials and Methods
UNASSIGNED
We performed differential gene expression and differential transcript usage (DTU) analyses on messenger RNA datasets from the livers of both chickens and humans with fatty liver disease. Using appropriate cross-species gene identification methods, we reviewed the acquired candidate genes and their transcript isoforms to determine their potential role in fatty liver disease's pathogenesis.
Results
UNASSIGNED
We identified seven genes -
Conclusion
UNASSIGNED
This study successfully identified novel human-chicken DTU genes in fatty liver disease. Further research is encouraged to verify the functions and regulations of these transcript isoforms as potential diagnostic markers for fatty liver disease in humans and chickens.
Identifiants
pubmed: 37859957
doi: 10.14202/vetworld.2023.1964-1973
pii: Vetworld-16-1964
pmc: PMC10583885
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1964-1973Informations de copyright
Copyright: © Chokeshaiusaha, et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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