Key aspects defining the development and implementation of a regional genomic surveillance strategy for the Eastern Mediterranean Region.

SARS‐CoV‐2 bioinformatics genomics influenza next‐generation sequencing whole genome sequencing

Journal

Influenza and other respiratory viruses
ISSN: 1750-2659
Titre abrégé: Influenza Other Respir Viruses
Pays: England
ID NLM: 101304007

Informations de publication

Date de publication:
10 2023
Historique:
received: 17 05 2023
revised: 24 08 2023
accepted: 20 09 2023
medline: 23 10 2023
pubmed: 20 10 2023
entrez: 20 10 2023
Statut: epublish

Résumé

The COVID-19 pandemic highlighted the critical role of pathogen sequencing in making informed public health decisions. Initially, the Eastern Mediterranean Region faced limitations in sequencing capacity. However, with robust WHO and stakeholder support, the situation significantly improved. By 2022, COVID-19 sequencing was underway in 22 out of 23 regional countries, with varying throughput and capacity. Notably, three genomic hubs were established in Oman, UAE, and Morocco, playing a key role in providing expanded genomics training and support across the region. While primarily for COVID-19 surveillance, this sequencing capacity offers an opportunity to integrate genomic surveillance into existing networks. This integration can enable early detection and response to high-threat pathogens with pandemic potential. To advance this, WHO/EMRO collaborated with stakeholders to formulate the Eastern Mediterranean Regional Genomic Surveillance Strategy for Emerging Pathogens of Pandemic Concern. Consultative meetings with regional and international genomic surveillance experts identified strategy focal points, key partners, priority pathogens, and implementation steps. As the strategy awaits member states' ratification in Q4 2023, this manuscript outlines pivotal facets defined by member states and the strategic document's key deliverables and opportunities. These efforts aim to yield a substantial positive impact within the region.

Identifiants

pubmed: 37859974
doi: 10.1111/irv.13205
pii: IRV13205
pmc: PMC10583647
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13205

Subventions

Organisme : World Health Organization
ID : 001
Pays : International

Informations de copyright

© 2023 World Health Organization; licensed by John Wiley & Sons Ltd. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.

Déclaration de conflit d'intérêts

The authors declare that they have no financial or personal relationships which may have inappropriately influenced them in the writing of this article. All authors are employed by WHO/EMRO.

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Auteurs

Luke W Meredith (LW)

Infectious Hazard Management, Department of Health Emergency World Health Organization, Eastern Mediterranean Regional Office Cairo Egypt.

Mustafa Aboualy (M)

Infectious Hazard Management, Department of Health Emergency World Health Organization, Eastern Mediterranean Regional Office Cairo Egypt.

Rachel Ochola (R)

Infectious Hazard Management, Department of Health Emergency World Health Organization, Eastern Mediterranean Regional Office Cairo Egypt.

Patrick Okwarah (P)

Infectious Hazard Management, Department of Health Emergency World Health Organization, Eastern Mediterranean Regional Office Cairo Egypt.

Mehmet Ozel (M)

Infectious Hazard Management, Department of Health Emergency World Health Organization, Eastern Mediterranean Regional Office Cairo Egypt.

Abdinasir Abubakar (A)

Infectious Hazard Management, Department of Health Emergency World Health Organization, Eastern Mediterranean Regional Office Cairo Egypt.

Amal Barakat (A)

Infectious Hazard Management, Department of Health Emergency World Health Organization, Eastern Mediterranean Regional Office Cairo Egypt.

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Classifications MeSH