Distinct mechanisms drive sequential internalization and degradation of GABA

Cellular neuroscience Molecular physiology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
20 Oct 2023
Historique:
received: 07 06 2023
revised: 30 08 2023
accepted: 22 09 2023
medline: 20 10 2023
pubmed: 20 10 2023
entrez: 20 10 2023
Statut: epublish

Résumé

Synaptic inhibition is critical for controlling neuronal excitability and function. During global cerebral ischemia (GCI), inhibitory synapses are rapidly eliminated, causing hyper-excitability which contributes to cell-death and the pathophysiology of disease. Sequential disassembly of inhibitory synapses begins within minutes of ischemia onset: GABA

Identifiants

pubmed: 37860758
doi: 10.1016/j.isci.2023.108061
pii: S2589-0042(23)02138-7
pmc: PMC10582478
doi:

Types de publication

Journal Article

Langues

eng

Pagination

108061

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interests.

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Auteurs

Joshua D Garcia (JD)

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.

Sarah E Wolfe (SE)

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.

Amber R Stewart (AR)

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.

Erika Tiemeier (E)

Department of Anesthesiology, Neuronal Injury Program, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.

Sara E Gookin (SE)

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.

Mayra Bueno Guerrero (MB)

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.

Nidia Quillinan (N)

Department of Anesthesiology, Neuronal Injury Program, University of Colorado School of Medicine, Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.

Katharine R Smith (KR)

Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 East 19th Avenue, Aurora, CO 80045, USA.

Classifications MeSH