Mechanisms underlying the health benefits of intermittent hypoxia conditioning.
cardiovascular diseases
cellular stress responses
intermittent hypoxia conditioning
mitochondria
neurological disorders
oxygen sensing
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
29
07
2023
accepted:
11
10
2023
medline:
20
10
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
aheadofprint
Résumé
Intermittent hypoxia (IH) is commonly associated with pathological conditions, particularly obstructive sleep apnoea. However, IH is also increasingly used to enhance health and performance and is emerging as a potent non-pharmacological intervention against numerous diseases. Whether IH is detrimental or beneficial for health is largely determined by the intensity, duration, number and frequency of the hypoxic exposures and by the specific responses they engender. Adaptive responses to hypoxia protect from future hypoxic or ischaemic insults, improve cellular resilience and functions, and boost mental and physical performance. The cellular and systemic mechanisms producing these benefits are highly complex, and the failure of different components can shift long-term adaptation to maladaptation and the development of pathologies. Rather than discussing in detail the well-characterized individual responses and adaptations to IH, we here aim to summarize and integrate hypoxia-activated mechanisms into a holistic picture of the body's adaptive responses to hypoxia and specifically IH, and demonstrate how these mechanisms might be mobilized for their health benefits while minimizing the risks of hypoxia exposure.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Ministry of Science and Innovation
ID : FJC2020-043385-I
Organisme : Russian Science Foundation
ID : 22-25-00781
Organisme : HORIZON EUROPE European Research Council
ID : 101054369
Organisme : Austrian Science Fund
ID : FWF W1206
Organisme : Ministero dell'Università e della Ricerca, Italia
ID : 2022E7FZEJ
Organisme : Max Planck Förderstiftung
Informations de copyright
© 2023 The Authors. The Journal of Physiology © 2023 The Physiological Society.
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