Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung.
conditional blastocyst complementation
developmental biology
human
lung generation
lung mesenchyme precursors
mesendoderm
mouse
thymus generation
whole organ generation
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 10 2023
20 10 2023
Historique:
received:
11
01
2023
accepted:
19
10
2023
medline:
14
11
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
epublish
Résumé
Millions suffer from incurable lung diseases, and the donor lung shortage hampers organ transplants. Generating the whole organ in conjunction with the thymus is a significant milestone for organ transplantation because the thymus is the central organ to educate immune cells. Using lineage-tracing mice and human pluripotent stem cell (PSC)-derived lung-directed differentiation, we revealed that gastrulating Foxa2 lineage contributed to both lung mesenchyme and epithelium formation. Interestingly, Foxa2 lineage-derived cells in the lung mesenchyme progressively increased and occupied more than half of the mesenchyme niche, including endothelial cells, during lung development.
Identifiants
pubmed: 37861292
doi: 10.7554/eLife.86105
pii: 86105
pmc: PMC10642968
doi:
pii:
Substances chimiques
Foxa2 protein, mouse
0
Hepatocyte Nuclear Factor 3-beta
135845-92-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148223
Pays : United States
Organisme : NIH HHS
ID : S10 OD032447
Pays : United States
Informations de copyright
© 2023, Miura et al.
Déclaration de conflit d'intérêts
AM, HS, JT, YH, AS, YS, TO, YK, YF, DS, ZN, JS, ND, JD, ST, JW, JQ, FH, CL, MM No competing interests declared
Références
Stem Cell Res. 2012 May;8(3):335-45
pubmed: 22286009
Nat Cell Biol. 2017 May;19(5):542-549
pubmed: 28436965
Elife. 2014 Oct 08;3:
pubmed: 25296024
Nat Biotechnol. 2011 Mar;29(3):267-72
pubmed: 21358635
Nature. 2013 Aug 29;500(7464):589-92
pubmed: 23873040
Am J Respir Crit Care Med. 2021 Feb 15;203(4):471-483
pubmed: 32877203
J Clin Invest. 2017 Jun 1;127(6):2277-2294
pubmed: 28463226
Nature. 2020 Nov;587(7835):619-625
pubmed: 33208946
Cell Transplant. 2019 Jan;28(1):5-17
pubmed: 30477315
Cell Stem Cell. 2012 Apr 6;10(4):355-61
pubmed: 22482501
Nat Protoc. 2014;9(6):1451-68
pubmed: 24874812
Elife. 2022 Nov 18;11:
pubmed: 36398878
Science. 2010 Jul 30;329(5991):538-41
pubmed: 20576850
Nat Commun. 2017 Feb 14;8:14428
pubmed: 28195173
Development. 2002 Aug;129(15):3597-608
pubmed: 12117810
Cell. 2010 Sep 3;142(5):787-99
pubmed: 20813264
Curr Opin Genet Dev. 2020 Oct;64:60-65
pubmed: 32619817
Wiley Interdiscip Rev Dev Biol. 2021 Nov;10(6):e399
pubmed: 33145915
Nat Cell Biol. 2021 Jul;23(7):692-703
pubmed: 34168324
Elife. 2022 Jan 12;11:
pubmed: 35018887
Nat Med. 2010 Aug;16(8):927-33
pubmed: 20628374
Cell. 2016 Jul 14;166(2):451-467
pubmed: 27419872
Nature. 2019 Feb;566(7745):490-495
pubmed: 30787436
Lancet Respir Med. 2022 Aug;10(8):796-810
pubmed: 35512715
Stem Cell Reports. 2016 Jan 12;6(1):18-25
pubmed: 26724905
Development. 2004 Feb;131(4):953-64
pubmed: 14757645
Sci Rep. 2022 Feb 25;12(1):3242
pubmed: 35217706
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2208-13
pubmed: 16452165
Nat Med. 2014 Aug;20(8):822-32
pubmed: 25100528
Stem Cell Reports. 2018 Oct 9;11(4):988-997
pubmed: 30245211
Development. 2010 Oct;137(20):3361-72
pubmed: 20826533
Nat Genet. 1999 Jan;21(1):138-41
pubmed: 9916808
Am J Pathol. 2012 Jun;180(6):2417-26
pubmed: 22507837
Stem Cell Reports. 2014 Sep 9;3(3):394-403
pubmed: 25241738
Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11895-9
pubmed: 10518547
Am Rev Respir Dis. 1982 Aug;126(2):332-7
pubmed: 7103258
J Clin Invest. 2011 Jun;121(6):2313-25
pubmed: 21537085
Nat Biotechnol. 2014 Jan;32(1):84-91
pubmed: 24291815
Development. 2005 Oct;132(19):4363-74
pubmed: 16141227
J Appl Physiol Respir Environ Exerc Physiol. 1979 Feb;46(2):399-406
pubmed: 422457
Nat Commun. 2020 Aug 27;11(1):4159
pubmed: 32855415
Nat Commun. 2020 Aug 27;11(1):4158
pubmed: 32855417
Int J Chron Obstruct Pulmon Dis. 2010 Apr 07;5:81-8
pubmed: 20463889
Dev Dyn. 2007 Dec;236(12):3459-71
pubmed: 17969154
Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61
pubmed: 22529374
Development. 1999 Sep;126(18):4005-15
pubmed: 10457010
Dev Biol. 2008 Jul 15;319(2):426-36
pubmed: 18533146
J Immunol. 2001 Aug 15;167(4):1954-61
pubmed: 11489975
Am J Physiol Renal Physiol. 2011 Aug;301(2):F245-51
pubmed: 21613421
Am J Respir Cell Mol Biol. 1992 Feb;6(2):235-43
pubmed: 1540387
Nature. 2017 Feb 9;542(7640):191-196
pubmed: 28117444
Dev Biol. 2008 Aug 15;320(2):340-50
pubmed: 18602626
Dev Biol. 2006 Nov 1;299(1):52-62
pubmed: 16989802
Development. 2000 Feb;127(3):483-92
pubmed: 10631169
Nature. 2022 Sep;609(7928):779-784
pubmed: 36104564
Cell Rep. 2020 May 12;31(6):107626
pubmed: 32402288
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4528-32
pubmed: 8506294
Development. 2011 Apr;138(7):1235-45
pubmed: 21350014
Nat Med. 2019 Nov;25(11):1691-1698
pubmed: 31700187