Advanced Visualization Engineering for Vision Disorders: A Clinically Focused Guide to Current Technology and Future Applications.

Assessment Augmented reality Mixed reality Rehabilitation Simulation Virtual reality Vision disorders Visualization engineering

Journal

Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512

Informations de publication

Date de publication:
20 Oct 2023
Historique:
received: 30 06 2023
accepted: 04 10 2023
medline: 20 10 2023
pubmed: 20 10 2023
entrez: 20 10 2023
Statut: aheadofprint

Résumé

Head-mounted visualization technology, often in the form of virtual, augmented, and mixed reality (VAMR), has revolutionized how visual disorders may be approached clinically. In this manuscript, we review the available literature on VAMR for visual disorders and provide a clinically oriented guide to how VAMR technology has been deployed for visual impairments. The chief areas of clinical investigation with VAMR are divided include (1) vision assessment, (2) vision simulation, and (3) vision rehabilitation. We discuss in-depth the current literature of these areas in VAMR and upcoming/future applications to combat the detrimental impact of visual impairment worldwide.

Identifiants

pubmed: 37861913
doi: 10.1007/s10439-023-03379-8
pii: 10.1007/s10439-023-03379-8
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NASA
ID : 80NSSC20K183
Pays : United States

Informations de copyright

© 2023. The Author(s) under exclusive licence to Biomedical Engineering Society.

Références

Alawa, K. A., R. P. Nolan, E. Han, A. Arboleda, H. Durkee, M. S. Sayed, M. C. Aguilar, and R. K. Lee. Low-cost, smartphone-based frequency doubling technology visual field testing using a head-mounted display. Br. J. Ophthalmol. 105:440–444, 2021.
pubmed: 31530566 doi: 10.1136/bjophthalmol-2019-314031
Aleman, T. S., A. J. Miller, K. H. Maguire, E. M. Aleman, L. W. Serrano, K. B. O’Connor, E. C. Bedoukian, B. P. Leroy, A. M. Maguire, and J. Bennett. A virtual reality orientation and mobility test for inherited retinal degenerations: testing a proof-of-concept after gene therapy. OPTH. 15:939–952, 2021.
doi: 10.2147/OPTH.S292527
Alexander, D. J., C. R. Gibson, D. R. Hamilton, S. M. C. Lee, T. H. Mader, C. Otto, C. M. Oubre, A. F. Pass, S. H. Platts, J. M. Scott, S. M. Smith, M. B. Stenger, C. M. Westby, and S. B. Zanello. Previous Authors (July 2012).
Almutleb, E. S., and S. E. Hassan. The effect of simulated central field loss on street-crossing decision-making in young adult pedestrians. Optom Vis Sci. 97:229–238, 2020.
pubmed: 32304532 pmcid: 7259828 doi: 10.1097/OPX.0000000000001502
Altangerel, U., H. S. Nallamshetty, T. Uhler, J. Fontanarosa, W. C. Steinmann, J. M. Almodin, B. H. Chen, and J. D. Henderer. Knowledge about glaucoma and barriers to follow-up care in a community glaucoma screening program. Can. J. Ophthalmol. 44:66–69, 2009.
pubmed: 19169316 doi: 10.3129/i08-175
Anik, A. A., B. A. Xavier, J. Hansmann, E. Ansong, J. Chen, L. Zhao, and E. Michals. Accuracy and reproducibility of linear and angular measurements in virtual reality: a validation study. J. Digit. Imaging. 33:111–120, 2020.
pubmed: 31396777 doi: 10.1007/s10278-019-00259-3
Aniruddha, P., N. Zaman, A. Tavakkoli, and S. Zuckerbrod. A parametric perceptual deficit modeling and diagnostics framework for retina damage using mixed reality. In: Advances in Visual Computing: 14th International Symposium on Visual Computing, ISVC 2019, Lake Tahoe, NV, USA. 11845:258–269, 2019.
Arvind, H., A. Klistorner, S. Graham, J. Grigg, I. Goldberg, A. Klistorner, and F. A. Billson. Dichoptic stimulation improves detection of glaucoma with multifocal visual evoked potentials. Invest. Ophthalmol. Vis. Sci. 48:4590–4596, 2007.
pubmed: 17898282 doi: 10.1167/iovs.07-0318
Ates, H. C., A. Fiannaca, and E. Folmer. Immersive simulation of visual impairments using a wearable see-through display. In: Proceedings of the Ninth International Conference on Tangible, Embedded, and Embodied Interaction, pp. 225–228, 2015. https://doi.org/10.1145/2677199.2680551 .
Azuma, R. T. A survey of augmented reality. Presence. 6:355–385, 1997.
doi: 10.1162/pres.1997.6.4.355
Backus, B. T., T. Tran, and J. Blaha. Clinical use of the Vivid Vision system to treat disorders of binocular vision. 2017.
Barrett, P. M., R. Komatireddy, S. Haaser, S. Topol, J. Sheard, J. Encinas, A. J. Fought, and E. J. Topol. Comparison of 24-hour Holter monitoring with 14-day novel adhesive patch electrocardiographic monitoring. Am. J. Med. 127(95):e11-17, 2014.
Bennett, C. R., P. J. Bex, C. M. Bauer, and L. B. Merabet. The assessment of visual function and functional vision. Semin. Pediatr. Neurol. 31:30–40, 2019.
pubmed: 31548022 pmcid: 6761988 doi: 10.1016/j.spen.2019.05.006
Blakemore, C., and B. Julesz. Stereoscopic depth aftereffect produced without monocular cues. Science. 171:286–288, 1971.
pubmed: 5538841 doi: 10.1126/science.171.3968.286
Bohil, C. J., B. Alicea, and F. A. Biocca. Virtual reality in neuroscience research and therapy. Nat. Rev. Neurosci. 12:752–762, 2011.
pubmed: 22048061 doi: 10.1038/nrn3122
Bohr, I., and J. C. A. Read. Stereoacuity with Frisby and revised FD2 stereo tests. PLoS ONE.8:e82999, 2013.
pubmed: 24349416 pmcid: 3861460 doi: 10.1371/journal.pone.0082999
Bookwala, J., and B. Lawson. Poor vision, functioning, and depressive symptoms: a test of the activity restriction model. Gerontologist. 51:798–808, 2011.
pubmed: 21737397 pmcid: 3254152 doi: 10.1093/geront/gnr051
Bramley, T., P. Peeples, J. G. Walt, M. Juhasz, and J. E. Hansen. Impact of vision loss on costs and outcomes in medicare beneficiaries with glaucoma. Arch. Ophthalmol. 126:849–856, 2008.
pubmed: 18541852 doi: 10.1001/archopht.126.6.849
Brown, G. C., M. M. Brown, and S. Sharma. Difference between ophthalmologists’ and patients’ perceptions of quality of life associated with age-related macular degeneration. Can. J. Ophthalmol. 35:127–133, 2000.
pubmed: 10812481 doi: 10.1016/S0008-4182(00)80005-8
Brown, R. L., and A. E. Barrett. Visual impairment and quality of life among older adults: an examination of explanations for the relationship. J. Gerontol. B. 66:364–373, 2011.
doi: 10.1093/geronb/gbr015
Bruun-Jensen, J. Visual field screening with a laptop computer system. Optometry. 82:519–527, 2011.
pubmed: 21871394 doi: 10.1016/j.optm.2010.09.016
Capri, J., H. McLeod, L. V. Messner, A. S. Hariprasad, and D. Leong. Color contrast sensitivity in age-related macular degeneration (AMD). Investig. Ophthalmol. Vis. Sci. 59:2418, 2018.
Cheung, S.-H., and G. E. Legge. Functional and cortical adaptations to central vision loss. Vis. Neurosci. 22:187–201, 2005.
pubmed: 15935111 pmcid: 1255967 doi: 10.1017/S0952523805222071
Cholewiak, S. A., G. D. Love, P. P. Srinivasan, R. Ng, and M. S. Banks. Chromablur: rendering chromatic eye aberration improves accommodation and realism. ACM Trans. Graph. 36:210:1-210:12, 2017.
doi: 10.1145/3130800.3130815
Coco-Martin, M. B., D. P. Piñero, L. Leal-Vega, C. J. Hernández-Rodríguez, J. Adiego, A. Molina-Martín, D. de Fez, and J. F. Arenillas. The potential of virtual reality for inducing neuroplasticity in children with amblyopia. J. Ophthalmol. 2020:7067846, 2020.
pubmed: 32676202 pmcid: 7341422 doi: 10.1155/2020/7067846
Colenbrander, A. Aspects of vision loss—visual functions and functional vision. Vis. Impair. Res. 5:115–136, 2003.
doi: 10.1080/1388235039048919
Corn, A. L., and J. N. Erin. Foundations of Low Vision: Clinical and Functional Perspectives. New York: American Foundation for the Blind, 2010.
Crabb, D. P. A view on glaucoma—are we seeing it clearly? Eye. 30:304–313, 2016.
pubmed: 26611846 doi: 10.1038/eye.2015.244
Craddock, G., C. Doran, and L. McNutt. Transforming Our World Through Design, Diversity and Education: Proceedings of Universal Design and Higher Education in Transformation Congress 2018. IOS Press, Amsterdam, 2018.
Creighton, R. H. Unity 3D game development by example : a seat-of-your-pants manual for building fun, groovy little games quickly. Packt Publishing, 2010. https://www.biblio.com/book/unity-3d-game-development-example-seat/d/1446159679 .
Crudden, A., L. W. McBroom, A. L. Skinner, and J. E. Moore. Comprehensive examination of barriers to employment among persons who are blind or visually impaired. Mississippi State University, Rehabilitation Research and Training Center on Blindness and Low Vision, 1998. https://eric.ed.gov/?id=ED419309 .
Culham, L. E., A. Chabra, and G. S. Rubin. Clinical performance of electronic, head-mounted, low-vision devices. Ophthalmic Physiol. Opt. 24:281–290, 2004.
pubmed: 15228505 doi: 10.1111/j.1475-1313.2004.00193.x
Culham, L. E., A. Chabra, and G. S. Rubin. Users’ subjective evaluation of electronic vision enhancement systems. Ophthalmic Physiol. Opt. 29:138–149, 2009.
pubmed: 19236583 doi: 10.1111/j.1475-1313.2008.00630.x
Damato, B., and C. Groenewald. Multifixation campimetry on line: a perimeter for the detection of visual field loss using the internet. Br. J. Ophthalmol. 87:1296–1298, 2003.
pubmed: 14507769 pmcid: 1920763 doi: 10.1136/bjo.87.10.1296
Dascal, J., M. Reid, W. W. IsHak, B. Spiegel, J. Recacho, B. Rosen, and I. Danovitch. Virtual reality and medical inpatients: a systematic review of randomized. Control. Trials. Innov. Clin. Neurosci. 14:14–21, 2017.
De Letter, J., A. All, L. De Marez, V. Avramelos, P. Lambert, and G. Van Wallendael. Exploratory study on user’s dynamic visual acuity and quality perception of impaired images. 2020. https://doi.org/10.48550/arXiv.2001.03542 .
doi: 10.48550/arXiv.2001.03542
Deemer, A. D., C. K. Bradley, N. C. Ross, D. M. Natale, R. Itthipanichpong, F. S. Werblin, and R. W. Massof. Low vision enhancement with head-mounted video display systems: are we there yet? Optom. Vis. Sci. 95:694–703, 2018.
pubmed: 30153240 pmcid: 6119088 doi: 10.1097/OPX.0000000000001278
Demmin, D. L., and S. M. Silverstein. Visual impairment and mental health: unmet needs and treatment options. Clin. Ophthalmol. 14:4229–4251, 2020.
pubmed: 33299297 pmcid: 7721280 doi: 10.2147/OPTH.S258783
Dundon, N. M., C. Bertini, E. Làdavas, B. A. Sabel, and C. Gall. Visual rehabilitation: visual scanning, multisensory stimulation and vision restoration trainings. Front. Behav. Neurosci. 9:192, 2015.
pubmed: 26283935 pmcid: 4515568 doi: 10.3389/fnbeh.2015.00192
Eastgate, R. M., G. D. Griffiths, P. E. Waddingham, A. D. Moody, T. K. H. Butler, S. V. Cobb, I. F. Comaish, S. M. Haworth, R. M. Gregson, I. M. Ash, and S. M. Brown. Modified virtual reality technology for treatment of amblyopia. Eye (Lond). 20:370–374, 2006.
pubmed: 15832182 doi: 10.1038/sj.eye.6701882
Edemekong, P. F., D. L. Bomgaars, S. Sukumaran, and C. Schoo. Activities of daily living. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK470404/ .
Ellwein, L. B., V. Friedlin, A. M. McBean, and P. P. Lee. Use of eye care services among the 1991 Medicare population. Ophthalmology. 103:1732–1743, 1996.
pubmed: 8942864 doi: 10.1016/S0161-6420(96)30433-8
Everingham, M. R., B. T. Thomas, and T. Troscianko. Head-mounted mobility aid for low vision using scene classification techniques. Int. J. Virtual Real. 3:1–10, 1998.
doi: 10.20870/IJVR.1998.3.4.2629
Feng, X. LCD motion-blur analysis, perception, and reduction using synchronized backlight flashing. SPIE. 6057:213–226, 2006.
Fong, D. S., M. Sharza, W. Chen, J. F. Paschal, R. G. Ariyasu, and P. P. Lee. Vision loss among diabetics in a group model Health Maintenance Organization (HMO). Am. J. Ophthalmol. 133:236–241, 2002.
pubmed: 11812428 doi: 10.1016/S0002-9394(01)01364-2
Bourne, R., J. D. Steinmetz, and S. Flaxman. GBD 2019 blindness and vision impairment collaborators and vision loss expert group of the global burden of disease study. Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study. Lancet Glob. Health. 9:e130–e143, 2021.
doi: 10.1016/S2214-109X(20)30425-3
Gensheimer, M. W. G., R. Mazzoli, C. M. E. Reynolds, J. Pasternak, C. W. Kim, C. E. Chou, C. Cousineau-Krieger, M. J. Corsini, M. L. L. Groves, L. M. Colyer, C. D. K. Carlton, M. G. Legault, C. K. Miller, and L. C. J. Zimmerman. Eye trauma: initial care (CPG ID:03). Jt. Trauma Syst. Clin. Pract. Guidel.
Georgiadis, K., F. Kalaganis, P. Migkotzidis, E. Chatzilari, S. Nikolopoulos, and I. Kompatsiaris. A computer vision system supporting blind people—the supermarket case. In: Computer Vision Systems: 12th International Conference, ICVS 2019. 2019. https://doi.org/10.1007/978-3-030-34995-0_28 .
doi: 10.1007/978-3-030-34995-0_28
Gopal, S. K. S., J. Kelkar, A. Kelkar, and A. Pandit. Simplified updates on the pathophysiology and recent developments in the treatment of amblyopia: a review. Indian J. Ophthalmol. 67:1392–1399, 2019.
pubmed: 31436180 pmcid: 6727694 doi: 10.4103/ijo.IJO_11_19
Greenfield, J. A., M. Deiner, A. Nguyen, G. Wollstein, B. Damato, B. T. Backus, M. Wu, J. S. Schuman, and Y. Ou. Measurement reproducibility using Vivid Vision Perimetry: a virtual reality-based mobile platform. Investig. Ophthalmol. Vis. Sci. 61:4800, 2020.
Gusev, D. A., D. M. Whittinghill, and J. Yong. A simulator to study the effects of color and color blindness on motion sickness in virtual reality using head-mounted displays. In: Mobile and Wireless Technologies 2016. Springer, Berlin. 2016. https://doi.org/10.1007/978-981-10-1409-3_22 .
doi: 10.1007/978-981-10-1409-3_22
Heesterbeek, T. J., H. P. A. van der Aa, G. H. M. B. van Rens, J. W. R. Twisk, and R. M. A. van Nispen. The incidence and predictors of depressive and anxiety symptoms in older adults with vision impairment: a longitudinal prospective cohort study. Ophthalmic Physiol. Opt. 37:385–398, 2017.
pubmed: 28516509 doi: 10.1111/opo.12388
Hodge, S., and F. Eccles. Loneliness, Social Isolation and Sight Loss. Lancaster: Lancaster University, 2013.
Holford, K. C., A. E. Jagodinsky, R. Saripalle, and P. McAllister. Leveraging virtual reality for vestibular testing: clinical outcomes from tests of dynamic visual acuity. J. Vestib. Res. 32:15–20, 2022.
pubmed: 34633336 doi: 10.3233/VES-200782
Howard, M. C. A meta-analysis and systematic literature review of virtual reality rehabilitation programs. Comput. Hum. Behav. 70:317–327, 2017.
doi: 10.1016/j.chb.2017.01.013
Huang, M., J. Patel, and B. C. Patel. Optic Nerve Glioma. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK557878/ .
Ianchulev, T., P. Pham, V. Makarov, B. Francis, and D. Minckler. Peristat: a computer-based perimetry self-test for cost-effective population screening of glaucoma. Curr. Eye Res. 30:1–6, 2005.
pubmed: 15875358 doi: 10.1080/02713680490522399
Jeganathan, V. S. E., A. Kumagai, H. Shergill, M. D. Fetters, S. E. Moroi, J. Gosbee, D. S. Kim, J. D. Weiland, and J. R. Ehrlich. Design of smart head-mounted display technology: a convergent mixed-methods study. J. Vis. Impair. Blindness. 116:629–643, 2022.
doi: 10.1177/0145482X221130068
Jin, B., Z. Ai, and M. Rasmussen. Simulation of eye disease in virtual reality. In: 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. 2005. https://doi.org/10.1109/IEMBS.2005.1615631 .
doi: 10.1109/IEMBS.2005.1615631
Johnson, A., M. Allen, R. Pryzby, R. Wright, S. Robison, X. Scrimgeour, M. Zacharias, D. Hays, and K. Collins-Lee. Using health literacy principles to create a vision loss virtual reality (VR) app.
Jones, P. R., and G. Ometto. Degraded reality: using VR/AR to simulate visual impairments. In: 2018 IEEE Workshop on Augmented and Virtual Realities for Good (VAR4Good). IEEE. 2018. https://doi.org/10.1109/VAR4GOOD.2018.8576885 .
doi: 10.1109/VAR4GOOD.2018.8576885
Jones, P. R., T. Somoskeöy, H. Chow-Wing-Bom, and D. P. Crabb. Seeing other perspectives: evaluating the use of virtual and augmented reality to simulate visual impairments (OpenVisSim). NPJ Digit. Med. 3:1–9, 2020.
doi: 10.1038/s41746-020-0242-6
Joo, W.-J., J. Kyoung, M. Esfandyarpour, S.-H. Lee, H. Koo, S. Song, Y.-N. Kwon, S. H. Song, J. C. Bae, A. Jo, M.-J. Kwon, S. H. Han, S.-H. Kim, S. Hwang, and M. L. Brongersma. Metasurface-driven OLED displays beyond 10,000 pixels per inch. Science. 370:459–463, 2020.
pubmed: 33093108 doi: 10.1126/science.abc8530
Katibeh, M., H. Ziaei, E. Panah, H.-R. Moein, S. Hosseini, M. Kalantarion, A. Eskandari, and M. Yaseri. Knowledge and awareness of age related eye diseases: a population-based survey. J. Ophthalmic Vis. Res. 9:223–231, 2014.
pubmed: 25279125 pmcid: 4181206
Kelly, S. A., Y. Pang, and S. Klemencic. Reliability of the CSV-1000 in adults and children. Optometry Vis. Sci. 89:1172, 2012.
doi: 10.1097/OPX.0b013e318264097b
Kimura, T., C. Matsumoto, and H. Nomoto. Comparison of head-mounted perimeter (imo®) and humphrey field analyzer. Clin. Ophthalmol. 13:501–513, 2019.
pubmed: 30936681 pmcid: 6422415 doi: 10.2147/OPTH.S190995
Knight, R., and H. J. Griffiths. The effect of luminance on visual acuity with Fresnel prisms. Br. Ir. Orthopt. J. 8:29–32, 2011.
doi: 10.22599/bioj.37
Koenderink, J. J., and A. J. van Doorn. Representation of local geometry in the visual system. Biol. Cybern. 55:367–375, 1987.
pubmed: 3567240 doi: 10.1007/BF00318371
Krösl, K., D. Bauer, M. Schwärzler, H. Fuchs, G. Suter, and M. Wimmer. A VR-based user study on the effects of vision impairments on recognition distances of escape-route signs in buildings. Vis Comput. 34:911–923, 2018.
doi: 10.1007/s00371-018-1517-7
Krosl, K., C. Elvezio, M. Hurbe, S. Karst, S. Feiner, and M. Wimmer. XREye: simulating visual impairments in eye-tracked XR. In: 2020 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops (VRW), pp. 830–831, 2020. https://doi.org/10.1109/VRW50115.2020.00266 .
Krösl, K., C. Elvezio, M. Hürbe, S. Karst, M. Wimmer, and S. Feiner. ICthroughVR: illuminating cataracts through virtual reality. In: 2019 IEEE Conference on Virtual Reality and 3D User Interfaces (VR). 2019. https://doi.org/10.1109/VR.2019.8798239 .
Kuzmiene, L. Static perimetry. In: Biophysical Properties in Glaucoma: Diagnostic Technologies, edited by I. Januleviciene, and A. Harris. Cham: Springer, 2019, pp. 109–113. https://doi.org/10.1007/978-3-319-98198-7_15 .
Laffont, P.-Y., T. Martin, M. Gross, W. D. Tan, C. Lim, A. Au, and R. Wong. Rectifeye: a vision-correcting system for virtual reality. In: SIGGRAPH ASIA 2016 VR Showcase, 2016. https://doi.org/10.1145/2996376.2996382 .
Lampton, D. R., B. W. Knerr, S. L. Goldberg, J. P. Bliss, J. M. Moshell, and B. S. Blau. The virtual environment performance assessment battery (VEPAB): development and evaluation. Presence. 3:145–157, 1994.
doi: 10.1162/pres.1994.3.2.145
Lau, J. T. F., V. Lee, D. Fan, M. Lau, and J. Michon. Knowledge about cataract, glaucoma, and age related macular degeneration in the Hong Kong Chinese population. Br. J. Ophthalmol. 86:1080–1084, 2002.
pubmed: 12234882 pmcid: 1771305 doi: 10.1136/bjo.86.10.1080
Lawrenson, J. G., E. Graham-Rowe, F. Lorencatto, J. Burr, C. Bunce, J. J. Francis, P. Aluko, S. Rice, L. Vale, T. Peto, J. Presseau, N. Ivers, and J. M. Grimshaw. Interventions to increase attendance for diabetic retinopathy screening. Cochrane Database Syst. Rev. 1:CD012054, 2018.
pubmed: 29333660
Lee, A. G., T. H. Mader, C. R. Gibson, W. Tarver, P. Rabiei, R. F. Riascos, L. A. Galdamez, and T. Brunstetter. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update. NPJ Microgravity. 6:1–10, 2020.
Lee, H.-J., and S.-J. Kim. Effectiveness of binocularity-stimulating treatment in children with residual amblyopia following occlusion. BMC Ophthalmol. 18:253, 2018.
pubmed: 30236086 pmcid: 6149203 doi: 10.1186/s12886-018-0922-z
Li, S. L., A. Reynaud, R. F. Hess, Y.-Z. Wang, R. M. Jost, S. E. Morale, A. De La Cruz, L. Dao, D. Stager, and E. E. Birch. Dichoptic movie viewing treats childhood amblyopia. J. AAPOS. 19:401–405, 2015.
pubmed: 26486019 pmcid: 4659348 doi: 10.1016/j.jaapos.2015.08.003
Long, G. M., and D. F. Kearns. Visibility of text and icon highway signs under dynamic viewing conditions. Hum. Factors. 38:690–701, 1996.
doi: 10.1518/001872096778827215
Lorenzini, M.-C., J. Jarry, and W. Wittich. The impact of using eSight eyewear on functional vision and oculo-motor control in low vision patients. Investig. Ophthalmol. Vis. Sci. 58:3267, 2017.
Loriaut, P., P. Loriaut, P. Boyer, P. Massin, and I. Cochereau. Visual impairment and hip fractures: a case-control study in elderly patients. Ophthalmic Res. 52:212–216, 2014.
pubmed: 25378036 doi: 10.1159/000362881
Lotery, A., X. Xu, G. Zlatava, and J. Loftus. Burden of illness, visual impairment and health resource utilisation of patients with neovascular age-related macular degeneration: results from the UK cohort of a five-country cross-sectional study. Br. J. Ophthalmol. 91:1303–1307, 2007.
pubmed: 17504847 pmcid: 2000983 doi: 10.1136/bjo.2007.116939
Luo, G., and E. Peli. Use of an augmented-vision device for visual search by patients with tunnel vision. Investig. Ophthalmol. Vis. Sci. 47:4152–4159, 2006.
doi: 10.1167/iovs.05-1672
Lynch, K. A. Survey reveals myths and misconceptions abundant among hiring managers about the capabilities of people who are visually impaired. J. Vis. Impair. Blindness. 107:408–410, 2013.
doi: 10.1177/0145482X1310700603
Maggio, M. G., G. Maresca, R. De Luca, M. C. Stagnitti, B. Porcari, M. C. Ferrera, F. Galletti, C. Casella, A. Manuli, and R. S. Calabrò. The growing use of virtual reality in cognitive rehabilitation: fact, fake or vision? A scoping review. J. Natl. Med. Assoc. 111:457–463, 2019.
pubmed: 30739728
Mansouri, K., S. Orgül, F. Meier-Gibbons, and A. Mermoud. Awareness about glaucoma and related eye health attitudes in Switzerland: a survey of the general public. Ophthalmologica. 220:101–108, 2006.
pubmed: 16491032 doi: 10.1159/000090574
Masalkhi, M., J. Ong, E. Waisberg, J. Berdahl, and A. G. Lee. Intraocular pressure during spaceflight and risk of glaucomatous damage in prolonged microgravity. Encyclopedia. 3:1187–1196, 2023.
doi: 10.3390/encyclopedia3040086
Masalkhi, M., J. Ong, E. Waisberg, and A. G. Lee. Chorioretinal folds in astronauts: risk of chorioretinal fold-related maculopathy and terrestrial staging of disease. Eye. 2023. https://doi.org/10.1038/s41433-023-02730-6 .
doi: 10.1038/s41433-023-02730-6 pubmed: 37770534
Masalkhi, M., E. Waisberg, J. Ong, N. Zaman, P. Sarker, A. G. Lee, and A. Tavakkoli. Apple vision pro for ophthalmology and medicine. Ann. Biomed. Eng. 2023. https://doi.org/10.1007/s10439-023-03283-1 .
doi: 10.1007/s10439-023-03283-1 pubmed: 37332003
Maxhall, M., A. Backman, K. Bodin, L. Hedman, B. Sondell, and G. Bucht. Responses to a stroke training simulator. A pilot study. Int. J. Disab. Hum. Dev. 4:245–250, 2005.
Maxwell, D., E. Oster, and S. Lynch. Evaluating the applicability of repurposed entertainment virtual reality devices for military training. MODSIM World. 25:1–10, 2018.
Mees, L., S. Upadhyaya, P. Kumar, S. Kotawala, S. Haran, S. Rajasekar, D. S. Friedman, and R. Venkatesh. Validation of a head-mounted virtual reality visual field screening device. J. Glaucoma. 29:86–91, 2020.
pubmed: 31790067 doi: 10.1097/IJG.0000000000001415
Moglia, A., V. Ferrari, L. Morelli, M. Ferrari, F. Mosca, and A. Cuschieri. A systematic review of virtual reality simulators for robot-assisted surgery. Eur. Urol. 69:1065–1080, 2016.
pubmed: 26433570 doi: 10.1016/j.eururo.2015.09.021
Moharrer, M., S. Wang, B. E. Dougherty, W. Cybis, B. R. Ott, J. D. Davis, and G. Luo. Evaluation of the driving safety of visually impaired bioptic drivers based on critical events in naturalistic driving. Transl. Vis. Sci. Technol. 9:14, 2020.
pubmed: 32855861 pmcid: 7422772 doi: 10.1167/tvst.9.8.14
Montelongo, M., A. Gonzalez, F. Morgenstern, S. P. Donahue, and S. L. Groth. A virtual reality-based automated perimeter, device, and pilot study. Transl. Vis. Sci. Technol. 10:20, 2021.
pubmed: 34003954 pmcid: 7991920 doi: 10.1167/tvst.10.3.20
MSD. Barriers to Employment Identified by Blind and Vision-Impaired Persons in New Zealand—Ministry of Social Development. https://www.msd.govt.nz/about-msd-and-our-work/publications-resources/journals-and-magazines/social-policy-journal/spj26/26-barriers-to-employment-identified-by-blind-and-vision-impaired-persons-pages173-185.html .
Müller, A., J. E. Keeffe, and H. R. Taylor. Changes in eye care utilization following an eye health promotion campaign. Clin. Exp. Ophthalmol. 35:305–309, 2007.
pubmed: 17539780 doi: 10.1111/j.1442-9071.2007.01450.x
Naidoo, K. S., T. R. Fricke, K. D. Frick, M. Jong, T. J. Naduvilath, S. Resnikoff, and P. Sankaridurg. Potential lost productivity resulting from the global burden of myopia: systematic review, meta-analysis, and modeling. Ophthalmology. 126:338–346, 2019.
pubmed: 30342076 doi: 10.1016/j.ophtha.2018.10.029
National Research Council (US) Committee on Vision. Emergent Techniques for Assessment of Visual Performance. Washington (DC): National Academies Press (US), 1985. http://www.ncbi.nlm.nih.gov/books/NBK219047/ .
Ong, J., A. Tavakkoli, N. Zaman, S. A. Kamran, E. Waisberg, N. Gautam, and A. G. Lee. Terrestrial health applications of visual assessment technology and machine learning in spaceflight associated neuro-ocular syndrome. NPJ Microgravity. 8:37, 2022.
pubmed: 36008494 pmcid: 9411571 doi: 10.1038/s41526-022-00222-7
Ong, J., N. Zaman, S. A. Kamran, E. Waisberg, A. Tavakkoli, A. G. Lee, and M. Webster. A multi-modal visual assessment system for monitoring spaceflight associated neuro-ocular syndrome (SANS) during long duration spaceflight. J. Vis. 22:6, 2022.
doi: 10.1167/jov.22.3.6
Ong, J., N. Zaman, E. Waisberg, S. A. Kamran, A. G. Lee, and A. Tavakkoli. Head-mounted digital metamorphopsia suppression as a countermeasure for macular-related visual distortions for prolonged spaceflight missions and terrestrial health. Wearable Technol.3:e26, 2022.
doi: 10.1017/wtc.2022.21
Owsley, C. Visual processing speed. Vis. Res. 90:52–56, 2013.
pubmed: 23231958 doi: 10.1016/j.visres.2012.11.014
Palmer, S. E. Vision science: photons to phenomenology. Cambridge: The MIT Press, 1999.
Papakonstantinou, D., and K. Papadopoulos. The impact of information on employers’ attitudes towards employees with visual impairments. J. Vocat. Rehabil. 47:99–107, 2017.
doi: 10.3233/JVR-170886
Parihar, J. K. S. Glaucoma: the ‘Black hole’ of irreversible blindness. Med. J. Armed Forces India. 72:3–4, 2016.
pubmed: 26900214 pmcid: 4723712 doi: 10.1016/j.mjafi.2015.12.001
Park, H.-Y., H. Ryu, H.-Y. Kang, H. Lee, and J.-W. Kwon. Clinical and economic burden of visual impairment in an aging society of South Korea. Asia Pac. J. Public Health. 27:631–642, 2015.
pubmed: 26041834 doi: 10.1177/1010539515588944
Pelli, D. G. Crowding: a cortical constraint on object recognition. Curr. Opin. Neurobiol. 18:445–451, 2008.
pubmed: 18835355 pmcid: 3624758 doi: 10.1016/j.conb.2008.09.008
Pieramici, D. J., F. Heimann, R. Brassard, G. Barteselli, and S. Ranade. Virtual reality becomes a reality for ophthalmologic surgical clinical trials. Transl. Vis. Sci. Technol. 9:1, 2020.
pubmed: 32832208 pmcid: 7414641 doi: 10.1167/tvst.9.7.1
Randall, D., H. Griffiths, G. Arblaster, A. Bjerre, and J. Fenner. Simulation of oscillopsia in virtual reality. Br. Ir. Orthopt. J. 14:45–49, 2018.
pubmed: 32999964 pmcid: 7510383 doi: 10.22599/bioj.112
Reiss, F., A.-K. Meyrose, C. Otto, T. Lampert, F. Klasen, and U. Ravens-Sieberer. Socioeconomic status, stressful life situations and mental health problems in children and adolescents: results of the German BELLA cohort-study. PLoS ONE.14:e0213700, 2019.
pubmed: 30865713 pmcid: 6415852 doi: 10.1371/journal.pone.0213700
Rolland, J., and T. Hopkins. 1-A method of computational correction for optical distortion in head-mounted displays. 1993. https://www.semanticscholar.org/paper/1-A-Method-of-Computational-Correction-for-Optical-Rolland-Hopkins/6175f366325585b9feddaad383a2837b3fbaf99d .
Rosenthal, B. P., and M. Fischer. Chapter 51—functional vision changes in the normal and aging eye. In: A Comprehensive Guide to Geriatric Rehabilitation (Third Edition), edited by T. L. Kauffman, R. Scott, J. O. Barr, and M. L. Moran. Oxford: Churchill Livingstone, 2014, pp. 381–391. https://doi.org/10.1016/B978-0-7020-4588-2.00051-6 .
Rubin, G. S., K. Bandeen-Roche, G.-H. Huang, B. Muñoz, O. D. Schein, L. P. Fried, and S. K. West. The association of multiple visual impairments with self-reported visual disability: SEE project. Investig. Ophthalmol. Vis. Sci. 42:64–72, 2001.
Ruia, S., and K. Tripathy. Humphrey visual field. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2023. http://www.ncbi.nlm.nih.gov/books/NBK585112/ .
Rus-Calafell, M., P. Garety, E. Sason, T. J. K. Craig, and L. R. Valmaggia. Virtual reality in the assessment and treatment of psychosis: a systematic review of its utility, acceptability and effectiveness. Psychol. Med. 48:362–391, 2018.
pubmed: 28735593 doi: 10.1017/S0033291717001945
Salive, M. E., J. Guralnik, R. J. Glynn, W. Christen, R. B. Wallace, and A. M. Ostfeld. Association of visual impairment with mobility and physical function. J. Am. Geriatr. Soc. 42:287–292, 1994.
pubmed: 8120313 doi: 10.1111/j.1532-5415.1994.tb01753.x
Sarker, P., J. Ong, N. Zaman, S. A. Kamran, E. Waisberg, P. Paladugu, A. G. Lee, and A. Tavakkoli. Extended reality quantification of pupil reactivity as a non-invasive assessment for the pathogenesis of spaceflight associated neuro-ocular syndrome: a technology validation study for astronaut health. Life Sci. Space Res. 38:79–86, 2023.
doi: 10.1016/j.lssr.2023.06.001
Sarker, P., N. Zaman, J. Ong, P. Paladugu, M. Aldred, E. Waisberg, A. G. Lee, and A. Tavakkoli. Test-retest reliability of virtual reality devices in quantifying for relative afferent pupillary defect. Trans. Vis. Sci. Technol. 12:2, 2023.
doi: 10.1167/tvst.12.6.2
Saw, S.-M., G. Gazzard, D. Friedman, P. J. Foster, J. G. Devereux, M. L. Wong, and S. Seah. Awareness of glaucoma, and health beliefs of patients suffering primary acute angle closure. Br. J. Ophthalmol. 87:446–449, 2003.
pubmed: 12642308 pmcid: 1771598 doi: 10.1136/bjo.87.4.446
Sayed, A. M., M. Abdel-Mottaleb, R. Kashem, V. Roongpoovapatr, A. Elsawy, M. Abdel-Mottaleb, R. K. Parrish, and M. A. Shousha. Expansion of peripheral visual field with novel virtual reality digital spectacles. Am. J. Ophthalmol. 210:125–135, 2020.
pubmed: 31626763 doi: 10.1016/j.ajo.2019.10.006
Sayed, A. M., R. Kashem, M. Abdel-Mottaleb, V. Roongpoovapatr, T. K. Eleiwa, M. Abdel-Mottaleb, R. K. Parrish, and M. A. Shousha. Toward improving the mobility of patients with peripheral visual field defects with novel digital spectacles. Am. J. Ophthalmol. 210:136–145, 2020.
pubmed: 31606442 doi: 10.1016/j.ajo.2019.10.005
Scarfe, P., and A. Glennerster. Using high-fidelity virtual reality to study perception in freely moving observers. J. Vis. 15:3, 2015.
pubmed: 26161632 doi: 10.1167/15.9.3
Schor, C. M. A dynamic model of cross-coupling between accommodation and convergence: simulations of step and frequency responses. Optom. Vis. Sci. 69:258–269, 1992.
pubmed: 1565425 doi: 10.1097/00006324-199204000-00002
Scott, A. W., N. M. Bressler, S. Ffolkes, J. S. Wittenborn, and J. Jorkasky. Public attitudes about eye and vision health. JAMA Ophthalmol. 134:1111–1118, 2016.
pubmed: 27490785 doi: 10.1001/jamaophthalmol.2016.2627
Shen, T.-W., H.-Y. Hsu, and Y.-Z. Chen. Evaluation of visual acuity measurement based on the mobile virtual reality device. Math. Prob. Eng.2022:e1270565, 2022.
doi: 10.1155/2022/1270565
Shickle, D., and M. Griffin. Why don’t older adults in England go to have their eyes examined? Ophthalmic Physiol. Opt. 34:38–45, 2014.
pubmed: 24325433 doi: 10.1111/opo.12100
Shivakumar, F. OxSight uses augmented reality to aid the visually impaired, 2017. https://techcrunch.com/2017/02/16/oxsight-uses-augmented-reality-to-aide-the-visually-impaired/ .
Sircar, T., Z. Pradhan, A. Bopardikar, H. L. Rao, H. Agrawal, and V. N. Tiwari. Development and clinical validation of GearVision—a smartphone based head mounted perimeter. In: 2019 IEEE 16th India Council International Conference (INDICON). 2019. https://doi.org/10.1109/INDICON47234.2019.9030319 .
doi: 10.1109/INDICON47234.2019.9030319
Sproule, D., R. F. Jacinto, S. Rundell, J. Williams, S. Perlmutter, and S. Arndt. Characterization of visual acuity and contrast sensitivity using head-mounted displays in a virtual environment: a pilot study. Proc. Hum. Factors Ergonom. Soc. Annu. Meet. 63:547–551, 2019.
doi: 10.1177/1071181319631488
Stewart, C. E., A. R. Fielder, D. A. Stephens, and M. J. Moseley. Design of the monitored occlusion treatment of amblyopia study (MOTAS). Br J Ophthalmol. 86:915–919, 2002.
pubmed: 12140215 pmcid: 1771248 doi: 10.1136/bjo.86.8.915
Stock, S., C. Erler, and W. Stork. Realistic simulation of progressive vision diseases in virtual reality. In: Proceedings of the 24th ACM Symposium on Virtual Reality Software and Technology. 2018. https://doi.org/10.1145/3281505.3283395 .
doi: 10.1145/3281505.3283395
Swenor, B. K., B. Muñoz, and S. K. West. A longitudinal study of the association between visual impairment and mobility performance in older adults: the salisbury eye evaluation study. Am. J. Epidemiol. 179:313–322, 2014.
pubmed: 24148711 doi: 10.1093/aje/kwt257
Thevin, L., and T. Machulla. Three common misconceptions about visual impairments. In: 2020 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops (VRW). 2020. https://doi.org/10.1109/VRW50115.2020.00113 .
doi: 10.1109/VRW50115.2020.00113
Thompson, J. M. T., and J. M. Harris. Binocular vision: moving closer to reality. Philos. Trans. Soc. R. Lond. Ser. A. 362:2721–2739, 2004.
doi: 10.1098/rsta.2004.1464
Thonginnetra, O., V. C. Greenstein, D. Chu, J. M. Liebmann, R. Ritch, and D. C. Hood. Normal versus high tension glaucoma: a comparison of functional and structural defects. J. Glaucoma. 19:151–157, 2010.
pubmed: 19223786 pmcid: 2891909 doi: 10.1097/IJG.0b013e318193c45c
Tidow, G., K. D. Wühst, and H. de Marées. Dynamic Visual Acuity as a Performance-Influencing Factor in Sport. In: Training und Sport zur Prävention und Rehabilitation in der technisierten Umwelt/Training and Sport for Prevention and Rehabilitation in the Technicized Environment: Deutscher Sportärztekongreß Berlin, 27.–29. September 1984, edited by I.-W. Franz, H. Mellerowicz, and W. Noack. Berlin: Springer, 1985, pp. 353–358. https://doi.org/10.1007/978-3-642-70301-0_52 .
Tsapakis, S., D. Papaconstantinou, A. Diagourtas, S. Kandarakis, K. Droutsas, K. Andreanos, and D. Brouzas. Home-based visual field test for glaucoma screening comparison with Humphrey perimeter. Clin. Ophthalmol. 12:2597–2606, 2018.
pubmed: 30587906 pmcid: 6296209 doi: 10.2147/OPTH.S187832
Urwyler, P., N. Gruber, R. M. Müri, M. Jäger, R. Bieri, T. Nyffeler, U. P. Mosimann, and T. Nef. Age-dependent visual exploration during simulated day- and night driving on a motorway: a cross-sectional study. BMC Geriatr. 15:18, 2015.
pubmed: 25888141 pmcid: 4350319 doi: 10.1186/s12877-015-0015-2
Lopez, V., C. Johnson, N. Rady, G. Mijares, M. K. Durbin, A. Nicklin, and M. A. Shousha. Contrast sensitivity application for augmented reality wearable device. IOVS. 63:721, 2022.
Vargas-Martin, F. Augmented-view for restricted visual field: multiple device implementations. Optom. Vis. Sci. 79(11):715–723, 2002.
pubmed: 12462540 doi: 10.1097/00006324-200211000-00009
Väyrynen, J., A. Colley, and J. Häkkilä. Head mounted display design tool for simulating visual disabilities. In: Proceedings of the 15th International Conference on Mobile and Ubiquitous Multimedia. 2016. https://doi.org/10.1145/3012709.3012714 .
doi: 10.1145/3012709.3012714
Velázquez, R., C. N. Sánchez, and E. E. Pissaloux. Visual impairment simulator based on the hadamard product. Electron. Notes Theor. Comput. Sci. 329:169–179, 2016.
doi: 10.1016/j.entcs.2016.12.010
Versek, C., A. Rissmiller, A. Tran, M. Taya, K. Chowdhury, P. Bex, and S. Sridhar. Portable system for neuro-optical diagnostics using virtual reality display. Mil. Med. 184:584–592, 2019.
pubmed: 30901414 pmcid: 6433097 doi: 10.1093/milmed/usy286
Vingrys, A. J., J. K. Healey, S. Liew, V. Saharinen, M. Tran, W. Wu, and G. Y. X. Kong. Validation of a tablet as a tangent perimeter. Transl. Vis. Sci. Technol. 5:3, 2016.
pubmed: 27486553 pmcid: 4959816 doi: 10.1167/tvst.5.4.3
Waisberg, E., J. Ong, S. A. Kamran, N. Zaman, P. Paladugu, P. Sarker, A. Tavakkoli, and A. G. Lee. Further characterizing the physiological process of posterior globe flattening in spaceflight associated neuro-ocular syndrome with generative adversarial networks. J. Appl. Physiol. 134:150–151, 2023.
pubmed: 36592406 doi: 10.1152/japplphysiol.00747.2022
Waisberg, E., J. Ong, and A. G. Lee. Factors associated with optic disc edema development during spaceflight. JAMA Ophthalmol. 2023. https://doi.org/10.1001/jamaophthalmol.2023.0303 .
doi: 10.1001/jamaophthalmol.2023.0303 pubmed: 36928752
Waisberg, E., J. Ong, and A. G. Lee. Space radiation and the potential for early cataract development. Eye (London, England) (accepted).
Waisberg, E., J. Ong, M. Masalkhi, and A. G. Lee. Optic neuropathy in spaceflight-associated neuro-ocular syndrome (SANS). Ir. J. Med. Sci. 2023. https://doi.org/10.1007/s11845-023-03353-2 .
doi: 10.1007/s11845-023-03353-2 pubmed: 37422552 pmcid: 9918813
Waisberg, E., J. Ong, M. Masalkhi, A. G. Lee, and J. Berdahl. Anatomical considerations for reducing ocular emergencies during spaceflight. Ir. J. Med. Sci. 2023. https://doi.org/10.1007/s11845-023-03407-5 .
doi: 10.1007/s11845-023-03407-5 pubmed: 37422552 pmcid: 9918813
Waisberg, E., J. Ong, M. Masalkhi, N. Zaman, P. Sarker, A. G. Lee, and A. Tavakkoli. Apple Vision Pro and why extended reality will revolutionize the future of medicine. Ir. J. Med. Sci. 2023. https://doi.org/10.1007/s11845-023-03437-z .
doi: 10.1007/s11845-023-03437-z pubmed: 37422552 pmcid: 9918813
Waisberg, E., J. Ong, M. Masalkhi, N. Zaman, P. Sarker, A. G. Lee, and A. Tavakkoli. Apple Vision Pro: the future of surgery with advances in virtual and augmented reality. Ir. J. Med. Sci. 2023. https://doi.org/10.1007/s11845-023-03457-9 .
doi: 10.1007/s11845-023-03457-9 pubmed: 37422552 pmcid: 9918813
Waisberg, E., J. Ong, M. Masalkhi, N. Zaman, P. Sarker, A. G. Lee, and A. Tavakkoli. The future of ophthalmology and vision science with the Apple Vision Pro. Eye. 2023. https://doi.org/10.1038/s41433-023-02688-5 .
doi: 10.1038/s41433-023-02688-5 pubmed: 37857719
Waisberg, E., J. Ong, M. Masalkhi, N. Zaman, P. Sarker, A. G. Lee, and A. Tavakkoli. Apple Vision Pro and the advancement of medical education with extended reality. Can. Med. Ed. J. 2023. https://doi.org/10.36834/cmej.77634 .
doi: 10.36834/cmej.77634
Waisberg, E., J. Ong, P. Paladugu, S. A. Kamran, N. Zaman, A. Tavakkoli, and A. G. Lee. Advances in machine learning to detect preventable causes of blindness. Eye. 2022. https://doi.org/10.1038/s41433-022-02354-2 .
doi: 10.1038/s41433-022-02354-2 pubmed: 36509995
Waisberg, E., J. Ong, P. Paladugu, S. A. Kamran, N. Zaman, A. Tavakkoli, and A. G. Lee. Applying generative adversarial network techniques to portable ophthalmic imaging. Eye. 2022. https://doi.org/10.1038/s41433-022-02353-3 .
doi: 10.1038/s41433-022-02353-3 pubmed: 36509995
Waisberg, E., J. Ong, P. Paladugu, N. Zaman, S. A. Kamran, A. G. Lee, and A. Tavakkoli. Optimizing screening for preventable blindness with head-mounted visual assessment technology. J. Vis. Impair. Blindness. 116:579–581, 2022.
doi: 10.1177/0145482X221124186
Waisberg, E., J. Ong, N. Zaman, S. A. Kamran, A. G. Lee, and A. Tavakkoli. Stroboscopic augmented reality as an approach to mitigate gravitational transition effects during interplanetary spaceflight. Int. J. Aviat. Aeronaut. Aerosp. 9:6, 2022.
Waisberg, E., J. Ong, N. Zaman, S. A. Kamran, A. G. Lee, and A. Tavakkoli. A non-invasive approach to monitor anemia during long-duration spaceflight with retinal fundus images and deep learning. Life Sci. Space Res. 33:69–71, 2022.
doi: 10.1016/j.lssr.2022.04.004
Waisberg, E., J. Ong, N. Zaman, S. A. Kamran, A. G. Lee, and A. Tavakkoli. Head-mounted dynamic visual acuity for g-transition effects during interplanetary spaceflight: technology development and results from an early validation study. Aerosp. Med. Hum. Perform. 93:800–805, 2022.
pubmed: 36309801 doi: 10.3357/AMHP.6092.2022
Waisberg, E., J. Ong, N. Zaman, S. A. Kamran, P. Sarker, A. Tavakkoli, and A. G. Lee. Extended reality for strabismus screening in developing countries. Eye. 2023. https://doi.org/10.1038/s41433-023-02649-y .
doi: 10.1038/s41433-023-02649-y pubmed: 37857719
Waisberg, E., J. Ong, N. Zaman, P. Paladugu, S. A. Kamran, A. Tavakkoli, and A. G. Lee. The spaceflight contrast sensitivity hypothesis and its role to investigate the pathophysiology of spaceflight-associated neuro-ocular syndrome. Front. Ophthalmol. 3:1229748, 2023.
doi: 10.3389/fopht.2023.1229748
Waisbourd, M., O. M. Ahmed, J. Newman, M. Sahu, D. Robinson, L. Siam, C. B. Reamer, T. Zhan, M. Goldstein, S. Kurtz, M. R. Moster, L. A. Hark, and L. J. Katz. The effect of an innovative vision simulator (OrCam) on quality of life in patients with glaucoma. J. Vis. Impair. Blindness. 113:332–340, 2019.
doi: 10.1177/0145482X19869797
Wang, S., M. Moharrer, V. Baliutaviciute, B. E. Dougherty, W. Cybis, A. R. Bowers, and G. Luo. Bioptic telescope use in naturalistic driving by people with visual impairment. Transl. Vis. Sci. Technol. 9:11, 2020.
pubmed: 32855858 pmcid: 7422818 doi: 10.1167/tvst.9.4.11
Werfel, F., R. Wiche, J. Feitsch, and C. Geiger. Empathizing audiovisual sense impairments: interactive real-time illustration of diminished sense perception. In: Proceedings of the 7th Augmented Human International Conference. 2016. https://doi.org/10.1145/2875194.2875226 .
doi: 10.1145/2875194.2875226
The SEE Project. West, S. K., G. S. Rubin, A. T. Broman, B. Muñoz, K. Bandeen-Roche, K. Turano, and for the SEE Project Team. How does visual impairment affect performance on tasks of everyday life? Arch. Ophthalmol. 120:774–780, 2002.
doi: 10.1001/archopht.120.6.774
Wittich, W., M.-C. Lorenzini, J. E. Goldstein, S. N. Markowitz, B. E. Patino, K. Lindeman, S. Braudway, S. A. Gartner, L. Godsay, A. Howson, M. Tolentino, T. Jayasundera, S. Reyes, and G. Dagnelie. eQUEST: the eSight quality of life and efficacy study. Investig. Ophthalmol. Vis. Sci. 58:4764, 2017.
Wolffe, K. E., and A. R. Candela. A qualitative analysis of employers’ experiences with visually impaired workers. J. Vis. Impair. Blindness. 96:622–634, 2002.
doi: 10.1177/0145482X0209600903
Wood, J., A. Chaparro, T. Carberry, and B. S. Chu. Effect of simulated visual impairment on nighttime driving performance. Optom. Vis. Sci. 87:379–386, 2010.
pubmed: 20386352 doi: 10.1097/OPX.0b013e3181d95b0d
Wroblewski, D., B. A. Francis, A. Sadun, G. Vakili, and V. Chopra. Testing of visual field with virtual reality goggles in manual and visual grasp modes. BioMed Res. Int.2014:e206082, 2014.
doi: 10.1155/2014/206082
Wu, H., D. H. Ashmead, H. Adams, and B. Bodenheimer. Using virtual reality to assess the street crossing behavior of pedestrians with simulated macular degeneration at a roundabout. Front. ICT. 5:27, 2018.
doi: 10.3389/fict.2018.00027
Zaman, N., A. Tavakkoli, and S. Zuckerbrod. A mixed reality system for modeling perceptual deficit to correct neural errors and recover functional vision. In 2020 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops (VRW). 2020. https://doi.org/10.1109/VRW50115.2020.00055 .
doi: 10.1109/VRW50115.2020.00055
Zao, J. K., Y.-Y. Chien, F.-C. Lin, Y.-T. Wang, M. Nakanishi, F. A. Medeiros, T.-P. Jung, and Y.-P. Huang. 37–4: invited paper: intelligent virtual-reality head-mounted displays with brain monitoring and visual function assessment. SID Symp. Dig. Tech. Pap. 49:475–478, 2018.
doi: 10.1002/sdtp.12604
Zhang, Q., Y. Guo, P.-Y. Laffont, T. Martin, and M. Gross. A virtual try-on system for prescription eyeglasses. IEEE Comput. Graph. Appl. 37:84–93, 2017.
pubmed: 28829296 doi: 10.1109/MCG.2017.3271458
Zhao, Y., E. Cutrell, C. Holz, M. R. Morris, E. Ofek, and A. D. Wilson. SeeingVR: a set of tools to make virtual reality more accessible to people with low vision. Proceedings of the 2019 CHI conference on human factors in computing systems. 2019. https://doi.org/10.1145/3290605.3300341 .
Zhao, Y., S. Szpiro, and S. Azenkot. ForeSee: a customizable head-mounted vision enhancement system for people with low vision. In: Proceedings of the 17th International ACM SIGACCESS Conference on Computers & Accessibility, pp. 239–249, 2015. https://doi.org/10.1145/2700648.2809865 .
Zhao, Y., S. Szpiro, J. Knighten, and S. Azenkot. CueSee: exploring visual cues for people with low vision to facilitate a visual search task. In: Proceedings of the 2016 ACM International Joint Conference on Pervasive and Ubiquitous Computing, pp. 73–84, 2016. https://doi.org/10.1145/2971648.2971730 .
doi: 10.1145/2971648.2971730
Zhao, Y., S. Szpiro, L. Shi, and S. Azenkot. Designing and evaluating a customizable head-mounted vision enhancement system for people with low vision. ACM Trans. Access. Comput. 12:151–1546, 2019.
doi: 10.1145/3361866
Žiak, P., A. Holm, J. Halička, P. Mojžiš, and D. P. Piñero. Amblyopia treatment of adults with dichoptic training using the virtual reality oculus rift head mounted display: preliminary results. BMC Ophthalmol. 17(1):105, 2017. https://doi.org/10.1186/s12886-017-0501-8 .
pubmed: 28659140 pmcid: 5490155 doi: 10.1186/s12886-017-0501-8
Cloud-based augmented/virtual reality platform receives class I listing with FD, 2020. https://www.ophthalmologytimes.com/view/cloud-based-augmented-virtual-reality-platform-receives-class-i-listing-with-fda .
Product Lineup | FOVE Official Website, 2021. https://fove-inc.com/product/ , https://fove-inc.com/product/ .
FundamentalVR raises $20M to grow its surgical VR platform, 2022. https://www.auganix.org/fundamentalvr-announces-it-has-raised-20m-to-further-grow-its-vr-surgical-simulation-platform/ .
Vision impairment and blindnessat. https://www.who.int/news-room/fact-sheets/detail/blindness-and-visual-impairment .
Oculus Rift S: PC-Powered VR Gaming Headset | Oculusat. https://www.oculus.com/rift-s/ .
SAMSUNG | Samsung UKat. https://www.samsung.com/ie/common/error/ .
Glass – Glassat. https://www.google.com/glass/start/ .
VIVE VR Headsets, Immersive Glasses & Equipment | United Statesat. https://www.vive.com/us/product/ .
Game Development and Simulation with Unreal Technology, Second Editionat. https://www.routledge.com/Game-Development-and-Simulation-with-Unreal-Technology-Second-Edition/Tavakkoli/p/book/9781138092198 .
Unreal Engine 5.1 Documentationat. https://docs.unrealengine.com/5.1/en-US/ .
Vision Assessment: Shaping Technology in 21st Century Societyat. https://doi.org/10.1007/978-3-642-59702-2 .
Effects of VR-Displays on Visual Acuity | TU Wien – Research Unit of Computer Graphicsat. https://www.cg.tuwien.ac.at/research/publications/2019/panfili-2019-VAVR/ .
Clinical Procedures in Primary Eye Care—5th Editionat. https://www.elsevier.com/books/clinical-procedures-in-primary-eye-care/elliott/978-0-7020-7789-0 .
VR headset—Varjo VR-3 | Highest resolution virtual reality | Varjoat. https://varjo.com/products/vr-3/ .
Full article: Visual Impairment and Mental Health: Unmet Needs and Treatment Optionsat. https://doi.org/10.2147/OPTH.S258783 .
Empath-D | Proceedings of the 16th Annual International Conference on Mobile Systems, Applications, and Servicesat. https://doi.org/10.1145/3210240.3211108 .
Gordois, A., H. Cutler, L. Pezzullo, K. Gordon, A. Cruess, S. Winyard, W. Hamilton, and K. Chua. An estimation of the worldwide economic and health burden of visual impairment. Glob. Public Health. 7(5):465–481, 2012.
pubmed: 22136197 doi: 10.1080/17441692.2011.634815
Panfili, L. Effects of VR-Displays on Visual Acuity. Vienna: Technische Universität Wien, 2019.
Ong, J., N. Zaman, E. Waisberg, S.A. Kamran, A.G. Lee, and A. Tavakkoli. Head-Mounted Digital Metamorphopsia Suppression as a Countermeasure for Macular-Related Visual Distortions for Prolonged Spaceflight Missions and Terrestrial Health. Cambridge: Cambridge University Press, 2022.
doi: 10.1017/wtc.2022.21
Qiu, Q., D.A. Ramirez, S. Saleh, G.G. Fluet, H.D. Parikh, D. Kelly, and S.V. Adamovich. The New Jersey Institute of Technology Robot-Assisted Virtual Rehabilitation (NJIT-RAVR) system for children with cerebral palsy: a feasibility study. J. Neuroeng. Rehabil. 6:40, 2009.
pubmed: 19917124 pmcid: 2781812 doi: 10.1186/1743-0003-6-40
Waddingham, P.Ε., S.V. Cobb, R.M. Eastgate, and R.M. Gregson. Virtual reality for interactive binocular treatment of amblyopia. Int. J. Disabil. Hum. Dev. 2011. https://doi.org/10.1515/IJDHD.2006.5.2.155 .
doi: 10.1515/IJDHD.2006.5.2.155
Vedamurthy, I., D. C. Knill, S. J. Huang, A. Yung, J. Ding, O. S. Kwon, D. Bavelier, and D. M. Levi. Recovering stereo vision by squashing virtual bugs in a virtual reality environment. Philos. Trans. R. Soc. Lond. B 371(1697):20150264, 2016.
pubmed: 27269607 pmcid: 4901458 doi: 10.1098/rstb.2015.0264
Boon, M. Y., L. J. Asper, P. Chik, P. Alagiah, and M. Ryan. Treatment and compliance with virtual reality and anaglyph-based training programs for convergence insufficiency. Clin. Exp. Optom. 103(6):870–876, 2020.
pubmed: 32201990 doi: 10.1111/cxo.13057
Yaramothu, C., J. V. d’Antonio-Bertagnolli, E. M. Santos, P. C. Crincoli, J. V. Rajah, M. Scheiman, and T. L. Alvarez. Proceedings #37: Virtual Eye Rotation Vision Exercises (VERVE): A Virtual Reality Vision Therapy Platform with Eye Tracking. New York: Elsevier, 2019.
doi: 10.1016/j.brs.2018.12.206
Gopalakrishnan, S., C. E. S. Jacob, M. Kumar, V. Karunakaran, and R. Raman. Comparison of visual parameters between normal individuals and people with low vision in a virtual environment. Cyberpsychol. Behav. Soc. Netw. 23(3):171–178, 2020.
pubmed: 32150699 doi: 10.1089/cyber.2019.0235
Saraiva, A. A., M. P. Barros, A. T. Nogueira, N. M. Fonseca Ferreira, and A. Valente. Virtual interactive environment for low-cost treatment of mechanical strabismus and amblyopia. Information 9(7), 175, 2020. https://doi.org/10.3390/info9070175 .
Greuter, S., R. Woodcock, L. Torre, A. Douglass, G. Sampson, L. Chong, J. Armitage, S. Backhouse. AmblyopiaVR: immersive game-based virtual reality system for the treatment of amblyopia. In: Proceedings of Australasian Computer Science Week (ACSW 2020). New York: ACM, pp 1–5, 2020.
Peli, E., L. Luo, A. Bowers, and N. Rensing. Applications of augmented vision head-mounted systems in vision rehabilitation. J. Soc. Inf. Disp. 15(12):1037–1045, 2007.
pubmed: 18172511 pmcid: 2171331 doi: 10.1889/1.2825088
Merino-Gracia, C., K. Lenc, M. Mirmehdi. A head-mounted device for recognizing text in natural scienes. Lect. Note. Comput. Sci, 2011. https://doi.org/10.1007/978-3-642-29364-1_3 .
Hicks, J. D., R. A. Flanagan, P. V. Petrov, A. D. Stoyen. Eyekon: augmented reality for battlefield soldiers. In: Published in: 27th Annual NASA Goddard/IEEE Software Engineering Workshop. Greenbelt: IEEE, 2013.
Tanuwidjaja, E., D. Huynh, K. Koa, C. Nguyen, C. Shao, P. Torbett, C. Emmenegger, and N. Weibel, Chroma: a wearable augmented-reality solution for color blindness. In: Proceedings of the 2014 ACM International Joint Conference on Pervasive and Ubiquitous Computing, pp. 799–810, 2014. https://doi.org/10.1145/2632048.2632091 .
Ruffieux, S, N. Ruffieux, R. Caldara, and D. Lalanne. i KnowU–exploring the potential of multimodal AR smart glasses for the decoding and rehabilitation of face processing in clinical populations. In: Human-Computer Interaction–INTERACT 2017: 16th IFIP TC 13 International Conference, Mumbai, India, September 25–29, 2017, Proceedings, Part III 16, pp. 423–432. New York: Springer, 2017. https://doi.org/10.1007/978-3-319-67687-6_28 .
Melillo, P., D. Riccio, L. Di Perna, G. S. Di Baja, M. De Nino, S. Rossi, F. Testa, F. Simonelli, and M. Frucci. Wearable improved vision system for color vision deficiency correction. IEEE J. Transl. Eng. Health Med. 5:1–7, 2017.
doi: 10.1109/JTEHM.2017.2679746
Lorenzini, M. C. and W. Wittich. 19 virtual reality applications in the context of low-vision rehabilitation. Virtual Real. Health Rehabil. 2020. https://doi.org/10.1201/9780429351365-19 .
doi: 10.1201/9780429351365-19
Wittich, W., M. C. Lorenzini, S. N. Markowitz, M. Tolentino, S. A. Gartner, J. E. Goldstein, and G. Dagnelie. The effect of a head-mounted low vision device on visual function. Optom. Vis. Sci. 95(9):774, 2018.
pubmed: 30153237 pmcid: 6133226 doi: 10.1097/OPX.0000000000001262
Williams, M., K. K. Yao, and J. R. Nurse. ToARist: an augmented reality tourism app created through user-centred design, 2018. arXiv:1807.05759 .
Aguilar, C., and E. Castet. Evaluation of a gaze-controlled vision enhancement system for reading in visually impaired people. PLoS One.12(4):e0174910, 2017.
pubmed: 28380004 pmcid: 5381883 doi: 10.1371/journal.pone.0174910
Stearns, L., V. DeSouza, J. Yin, L. Findlater, and J. E. Froehlich. Augmented reality magnification for low vision users with the microsoft hololens and a finger-worn camera. In Proceedings of the 19th International ACM SIGACCESS Conference on Computers and Accessibility, pp. 361–362, 2017.
Albouys-Perrois, J., J. Laviole, J. Briant, A. Brock. Towards a multisensory augmented reality map for blind and low vision people: a participatory design approach. In: Proceedings of the 2018 CHI Conference on Human Factors in Computing Systems (CHI’18). Association for Computing Machinery, New York, NY, USA, 21–26 April, pp. 1–14, 2018.
Tang, R., L. F. Ma, Z. X. Rong, M. D. Li, J. P. Zeng, X. D. Wang, H. E. Liao, and J. H. Dong. Augmented reality technology for preoperative planning and intraoperative navigation during hepatobiliary surgery: a review of current methods. Hepatob. Pancreat. Dis. Int. 17(2):101–112, 2018.
doi: 10.1016/j.hbpd.2018.02.002
Zuniga, R., J. Magee. Conversation aid for people with low vision using head mounted display and computer vision emotion detection. In: Computers Helping People with Special Needs: 16th International Conference, ICCHP 2018, Linz, Austria, July 11–13, 2018, Proceedings, Part II 16, pp. 44–50. New York: Springer.
Gupta, A., K. Scott, and M. Dukewich. Innovative technology using virtual reality in the treatment of pain: does it reduce pain via distraction, or is there more to it? Pain Medicine. 19(1):151–159, 2018.
pubmed: 29025113 doi: 10.1093/pm/pnx109
Kinateder, M., J. Gualtieri, M. J. Dunn, W. Jarosz, X. D. Yang, and E. A. Cooper. Using an augmented reality device as a distance-based vision aid—promise and limitations. Optom. Vis. Sci. 95(9):727, 2018.
pubmed: 29877901 pmcid: 6133229 doi: 10.1097/OPX.0000000000001232
Chen, Y., Q. Wang, H. Chen, X. Song, H. Tang, and M. Tian. An overview of augmented reality technology. J. Phys. 1237(2), 022082, 2018.
Zhao, Y., E. Kupferstein, B. V. Castro, S. Feiner, and S. Azenkot. Designing AR visualizations to facilitate stair navigation for people with low vision. In: Proceedings of the 32nd Annual ACM Symposium on User Interface Software and Technology, pp. 387–402, 2019.
Koch, T. Simulation of diabetic Macular Edema in virtual reality. 2019.
Daga, F. B., E. Macagno, C. Stevenson, A. Elhosseiny, A. Diniz-Filho, E. R. Boer, J. Schulze, and F. A. Medeiros. Wayfinding and glaucoma: a virtual reality experiment. Investig. Ophthalmol. Visual Sci. 58(9):3343–3349, 2017.
doi: 10.1167/iovs.17-21849
Lam, M. C., H. K. Tee, S. S. M. Nizam, N. C. Hashim, N. A. Suwadi, S. Y. Tan, N. A. Abd Majid, H. Arshad, and S. Y. Liew. Interactive augmented reality with natural action for chemistry experiment learning. Tem J. 9(1):351–360, 2020.
Zavlanou, C. and A. Lanitis. Virtual reality-based simulation of age-related visual deficiencies: implementation and evaluation in the design process. In: Human Interaction and Emerging Technologies: Proceedings of the 1st International Conference on Human Interaction and Emerging Technologies (IHIET 2019), August 22–24, 2019, Nice, France, pp. 262–267, 2020. New York: Springer.
Kim, S. K., S. J. Kang, Y. J. Choi, M. H. Choi, and M. Hong. Augmented-reality survey: from concept to application. KSII Trans. Internet Inf. Syst. 2017. https://doi.org/10.3837/tiis.2017.02.019 .
doi: 10.3837/tiis.2017.02.019
Langlotz, T., Y. Itoh, and J. Sutton. Amplifying Human Vision Using Computational Glasses (2018). https://www.hci.otago.ac.nz/downloads/arive/2020/ARIVELecture4ComputationalGlasses.pdf

Auteurs

Nasif Zaman (N)

Human-Machine Perception Laboratory, University of Nevada, Reno, NV, USA.

Joshua Ong (J)

Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Ethan Waisberg (E)

University College Dublin School of Medicine, Belfield, Dublin 4, Ireland. ethan.waisberg@ucdconnect.ie.

Mouayad Masalkhi (M)

University College Dublin School of Medicine, Belfield, Dublin 4, Ireland.

Andrew G Lee (AG)

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.
The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, USA.
Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA.
University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Texas A&M College of Medicine, Bryan, TX, USA.
Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Alireza Tavakkoli (A)

Human-Machine Perception Laboratory, University of Nevada, Reno, NV, USA.

Stewart Zuckerbrod (S)

Houston Eye Associates, Houston, TX, USA.

Classifications MeSH