Collagen-EGCG Combination Synergistically Prevents UVB-Induced Skin Photoaging in Nude Mice.
anti-photoaging
antioxidative
collagen
epigallocatechin gallate
ultraviolet B
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
12
10
2023
received:
31
05
2023
pubmed:
21
10
2023
medline:
21
10
2023
entrez:
20
10
2023
Statut:
ppublish
Résumé
Ultraviolet (UV) radiation is a major cause of skin photoaging through generating excessive oxidative stress and inflammation. One of the strategies is to use photo-chemoprotectors, such as natural products with antioxidant and anti-inflammatory properties, to protect the skin from photo damage. The present study investigates the photoprotective potentials of topical administration of unhydrolyzed collagen, epigallocatechin gallate (EGCG), and their combination against ultraviolet B (UVB)-induced photoaging in nude mice. It is found that both the solo and combined pretreatments could recover UVB-induced depletion of antioxidative enzymes, including superoxide dismutase and glutathione peroxidase (GSH-Px), as well as an increase of lipid peroxide malondialdehyde and inflammatory tumor necrosis factor-α. Meanwhile, the UVB-stimulated skin collagen degradation is attenuated significantly with drug treatments, which is evidenced by expression analysis of matrix metalloproteinase-1 and hydroxyproline. Additionally, the mouse skin histology shows that the drug-pretreated groups possess decreased epidermis thickness and normal collagen fiber structure of the dermis layer. These results demonstrate that both EGCG and collagen can protect the skin against UVB-induced skin photoaging. Synergistically, the combination of them shows the maximum prevention to skin damage, showing its potential in the application of anti-photoaging formulation products.
Identifiants
pubmed: 37863121
doi: 10.1002/mabi.202300251
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300251Subventions
Organisme : Basic and Applied Basic Research Foundation of Guangdong Province
ID : 2021B1515140006
Organisme : Basic and Applied Basic Research Foundation of Guangdong Province
ID : 2021A1515012437
Organisme : Basic and Applied Basic Research Foundation of Guangdong Province
ID : 2021A1515011831
Organisme : Special projects in key areas for general colleges and universities of Guangdong Province
ID : 2021ZDZX2039
Organisme : Special projects in key areas for general colleges and universities of Guangdong Province
ID : 2021ZDZX2061
Organisme : Featured Innovation Projects for General Colleges and Universities of Guangdong Province
ID : 2022KTSCX042
Organisme : Featured Innovation Projects for General Colleges and Universities of Guangdong Province
ID : 2021KTSCX040
Organisme : Funds for PhD Researchers of Guangdong Medical University in 2023
ID : 4SG23184G
Organisme : Funds for PhD Researchers of Guangdong Medical University in 2023
ID : 4SG23233G
Organisme : Discipline Construction Project of Guangdong Medical University
ID : 1019K20220003
Informations de copyright
© 2023 Wiley-VCH GmbH.
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