Macrophage polarization and metabolism in atherosclerosis.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
20 10 2023
20 10 2023
Historique:
received:
15
06
2023
accepted:
29
09
2023
revised:
27
09
2023
medline:
1
11
2023
pubmed:
21
10
2023
entrez:
20
10
2023
Statut:
epublish
Résumé
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty deposits in the inner walls of vessels. These plaques restrict blood flow and lead to complications such as heart attack or stroke. The development of atherosclerosis is influenced by a variety of factors, including age, genetics, lifestyle, and underlying health conditions such as high blood pressure or diabetes. Atherosclerotic plaques in stable form are characterized by slow growth, which leads to luminal stenosis, with low embolic potential or in unstable form, which contributes to high risk for thrombotic and embolic complications with rapid clinical onset. In this complex scenario of atherosclerosis, macrophages participate in the whole process, including the initiation, growth and eventually rupture and wound healing stages of artery plaque formation. Macrophages in plaques exhibit high heterogeneity and plasticity, which affect the evolving plaque microenvironment, e.g., leading to excessive lipid accumulation, cytokine hyperactivation, hypoxia, apoptosis and necroptosis. The metabolic and functional transitions of plaque macrophages in response to plaque microenvironmental factors not only influence ongoing and imminent inflammatory responses within the lesions but also directly dictate atherosclerotic progression or regression. In this review, we discuss the origin of macrophages within plaques, their phenotypic diversity, metabolic shifts, and fate and the roles they play in the dynamic progression of atherosclerosis. It also describes how macrophages interact with other plaque cells, particularly T cells. Ultimately, targeting pathways involved in macrophage polarization may lead to innovative and promising approaches for precision medicine. Further insights into the landscape and biological features of macrophages within atherosclerotic plaques may offer valuable information for optimizing future clinical treatment for atherosclerosis by targeting macrophages.
Identifiants
pubmed: 37863894
doi: 10.1038/s41419-023-06206-z
pii: 10.1038/s41419-023-06206-z
pmc: PMC10589261
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
691Informations de copyright
© 2023. The Author(s).
Références
Cytokine Growth Factor Rev. 2021 Dec;62:42-53
pubmed: 34742632
Science. 2016 Apr 22;352(6284):aaf1098
pubmed: 27102489
Physiol Rev. 2022 Jan 1;102(1):411-454
pubmed: 34898294
Atherosclerosis. 2010 Feb;208(2):572-80
pubmed: 19683236
Nat Commun. 2022 Jan 11;13(1):215
pubmed: 35017526
Hypertension. 2011 Mar;57(3):490-6
pubmed: 21263115
Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):870-6
pubmed: 10195911
Cell Metab. 2011 Nov 2;14(5):575-85
pubmed: 22055501
Nat Immunol. 2016 Feb;17(2):159-68
pubmed: 26642357
Circ Res. 2016 Jul 22;119(3):414-7
pubmed: 27458196
Front Pharmacol. 2021 Nov 26;12:785220
pubmed: 34899348
Immunity. 2013 Apr 18;38(4):792-804
pubmed: 23601688
Biochem J. 1998 Nov 1;335 ( Pt 3):573-9
pubmed: 9794797
Mol Oncol. 2021 Nov;15(11):2823-2840
pubmed: 34245122
Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):
pubmed: 34782454
Cell Death Differ. 2023 May;30(5):1097-1154
pubmed: 37100955
Cell Mol Immunol. 2022 Mar;19(3):384-408
pubmed: 34876704
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10340-10345
pubmed: 16801531
Arterioscler Thromb Vasc Biol. 2022 May;42(5):659-676
pubmed: 35321563
Arterioscler Thromb Vasc Biol. 2020 May;40(5):1155-1167
pubmed: 32212851
J Intern Med. 2017 May;281(5):471-482
pubmed: 28345303
Circ Res. 2010 Sep 17;107(6):737-46
pubmed: 20651288
Cell Death Differ. 2022 Nov;29(11):2275-2287
pubmed: 35523956
J Am Coll Cardiol. 2008 Apr 1;51(13):1258-65
pubmed: 18371555
Cell Death Differ. 2022 Aug;29(8):1450-1465
pubmed: 35031770
Free Radic Biol Med. 2011 Nov 15;51(10):1903-9
pubmed: 21925592
Pharmacol Ther. 2020 Oct;214:107620
pubmed: 32599008
J Nucl Med. 2007 Nov;48(11):1800-15
pubmed: 17942804
Cell Metab. 2020 Mar 3;31(3):518-533.e10
pubmed: 32004476
Cell Death Differ. 2021 Nov;28(11):3022-3035
pubmed: 34091599
Immunity. 2013 Jan 24;38(1):79-91
pubmed: 23273845
JAMA. 2004 Oct 20;292(15):1845-52
pubmed: 15494582
Cell Death Differ. 2022 Jun;29(6):1107-1122
pubmed: 35581387
Nat Med. 2017 Dec;23(12):1481-1487
pubmed: 29106401
Cell Metab. 2007 Aug;6(2):137-43
pubmed: 17681149
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13531-6
pubmed: 14581613
Biochemistry. 2009 Jan 20;48(2):242-53
pubmed: 19140693
Biol Direct. 2022 Mar 8;17(1):6
pubmed: 35255936
Immunity. 2016 Nov 15;45(5):975-987
pubmed: 27814941
Nat Immunol. 2020 Jan;21(1):42-53
pubmed: 31768073
Cell Death Dis. 2022 May 18;13(5):467
pubmed: 35585052
Sci Adv. 2016 Jul 22;2(7):e1600224
pubmed: 27532042
J Exp Med. 2020 Nov 2;217(11):
pubmed: 32785653
Int J Mol Sci. 2021 Jan 01;22(1):
pubmed: 33401449
Innate Immun. 2015 Apr;21(3):255-65
pubmed: 24663337
J Am Coll Cardiol. 2021 Apr 6;77(13):1599-1611
pubmed: 33795033
Immunol Rev. 2014 Nov;262(1):153-66
pubmed: 25319333
PLoS One. 2017 Aug 17;12(8):e0183572
pubmed: 28817687
Nat Rev Immunol. 2013 Oct;13(10):709-21
pubmed: 23995626
Cell. 2012 Sep 28;151(1):138-52
pubmed: 23021221
Cell Mol Life Sci. 2020 May;77(10):1919-1932
pubmed: 31720740
Circ Res. 2010 Jan 8;106(1):203-11
pubmed: 19910578
Biol Direct. 2022 Dec 2;17(1):38
pubmed: 36461070
Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2792-7
pubmed: 22096099
Circ Res. 2011 Oct 28;109(10):1141-52
pubmed: 21921268
Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1330-1336
pubmed: 31653516
Biol Direct. 2022 Aug 18;17(1):20
pubmed: 35978367
Pharmacol Ther. 2001 Nov-Dec;92(2-3):135-45
pubmed: 11916534
J Nucl Med. 2014 Oct;55(10):1699-705
pubmed: 25214643
Curr Opin Lipidol. 2017 Apr;28(2):91-98
pubmed: 28134664
Cell Death Differ. 2021 Jul;28(7):2238-2256
pubmed: 33753901
Nat Immunol. 2012 Jan 08;13(2):136-43
pubmed: 22231519
Appl Immunohistochem Mol Morphol. 2021 Nov-Dec 01;29(10):741-749
pubmed: 34039839
Circ Res. 2017 May 26;120(11):1789-1799
pubmed: 28302649
J Clin Invest. 2007 Jan;117(1):195-205
pubmed: 17200719
Cell Mol Immunol. 2021 Mar;18(3):579-587
pubmed: 32934339
Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1731-8
pubmed: 24903093
Cell Death Differ. 2022 Sep;29(9):1790-1803
pubmed: 35264781
Cardiovasc Diabetol. 2018 Mar 29;17(1):46
pubmed: 29598820
Cell Metab. 2020 Nov 3;32(5):710-725
pubmed: 33027638
Front Immunol. 2022 Mar 30;13:843712
pubmed: 35432323
Physiol Rev. 2018 Oct 1;98(4):2523-2569
pubmed: 30156496
Nat Rev Drug Discov. 2021 Aug;20(8):589-610
pubmed: 33976384
Atherosclerosis. 2011 Oct;218(2):356-62
pubmed: 21813127
Cell Death Differ. 2021 Nov;28(11):3140-3160
pubmed: 34040168
Circ Res. 2014 Oct 24;115(10):875-83
pubmed: 25185259
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1782-90
pubmed: 27444197
Arch Biochem Biophys. 2000 Jan 15;373(2):435-41
pubmed: 10620369
Nat Cell Biol. 2003 Sep;5(9):781-92
pubmed: 12907943
J Am Coll Cardiol. 2012 Jan 10;59(2):166-77
pubmed: 22154776
Circulation. 2021 Jan 12;143(2):163-177
pubmed: 33222501
Nat Med. 2019 Oct;25(10):1576-1588
pubmed: 31591603
Cell Metab. 2006 Jul;4(1):13-24
pubmed: 16814729
Cell Rep. 2013 Jan 31;3(1):200-10
pubmed: 23333278
Biol Direct. 2022 Nov 25;17(1):34
pubmed: 36434686
Atherosclerosis. 1997 Nov;135(1):19-27
pubmed: 9395269
Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
pubmed: 10807742
Circulation. 2014 Apr 15;129(15):1551-9
pubmed: 24481950
J Lipid Res. 2010 Nov;51(11):3196-206
pubmed: 20650929
Front Pharmacol. 2021 Apr 26;12:657486
pubmed: 33981234
Biol Direct. 2021 Oct 20;16(1):18
pubmed: 34670590
Nature. 2021 Apr;592(7853):296-301
pubmed: 33731931
Nat Immunol. 2018 Jun;19(6):526-537
pubmed: 29777212
Int J Immunopathol Pharmacol. 2005 Jan-Mar;18(1):95-112
pubmed: 15698515
Cell. 2018 Jan 11;172(1-2):162-175.e14
pubmed: 29328911
Am J Pathol. 2008 Apr;172(4):1112-26
pubmed: 18321997
Circ Res. 2012 Jan 6;110(1):20-33
pubmed: 22052915
Cell Death Differ. 2008 Apr;15(4):660-6
pubmed: 18219320
Immunol Rev. 2015 Mar;264(1):182-203
pubmed: 25703560
Nat Rev Cardiol. 2020 Jan;17(1):52-63
pubmed: 31366922
Eur Heart J. 2020 Aug 14;41(31):2997-3004
pubmed: 32402086
J Clin Invest. 2017 Aug 1;127(8):2904-2915
pubmed: 28650342
Immunity. 2010 May 28;32(5):593-604
pubmed: 20510870
Nature. 2010 Apr 29;464(7293):1357-61
pubmed: 20428172
Aging Dis. 2019 Feb 01;10(1):71-81
pubmed: 30705769
Circ Res. 2020 Jul 17;127(3):402-426
pubmed: 32673538
J Gen Intern Med. 2021 Aug;36(8):2517-2518
pubmed: 32705476
Nature. 2021 Apr;592(7855):524-533
pubmed: 33883728
Nature. 2018 Jun;558(7709):301-306
pubmed: 29875409
Nat Rev Cardiol. 2015 Jan;12(1):10-7
pubmed: 25367649
Eur J Pharmacol. 2017 Dec 5;816:14-24
pubmed: 28989084
Cells. 2020 Jun 02;9(6):
pubmed: 32498363
Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):372-380
pubmed: 35172605
Atherosclerosis. 2012 Dec;225(2):461-8
pubmed: 23078881
Oncogene. 2009 Oct 29;28(43):3814-24
pubmed: 19668229
Immunity. 2014 Feb 20;40(2):274-88
pubmed: 24530056
Nat Rev Cardiol. 2019 Dec;16(12):727-744
pubmed: 31243391
Cell Death Differ. 2015 Feb;22(2):225-36
pubmed: 25146926
Arterioscler Thromb Vasc Biol. 2022 Nov;42(11):1283-1306
pubmed: 36134566
Cell Death Differ. 2022 Oct;29(10):2009-2023
pubmed: 35568718
Biol Direct. 2021 Aug 6;16(1):14
pubmed: 34362419
Cytokine. 2019 Oct;122:154141
pubmed: 28899579
J Lipid Res. 2017 May;58(5):895-906
pubmed: 28258089
Circulation. 2012 Jan 17;125(2):364-74
pubmed: 22144566
J Clin Invest. 2018 Mar 1;128(3):910-912
pubmed: 29457787
J Immunol. 2000 Jun 15;164(12):6166-73
pubmed: 10843666
Immunity. 2017 May 16;46(5):849-862.e7
pubmed: 28514690
Cell. 2013 Apr 11;153(2):362-75
pubmed: 23582326
J Immunol. 2008 Apr 15;180(8):5707-19
pubmed: 18390756
J Control Release. 2022 Sep;349:2-15
pubmed: 35779655
Science. 2015 Jul 17;349(6245):316-20
pubmed: 26185250
Int J Mol Sci. 2019 Nov 11;20(22):
pubmed: 31718020
J Clin Invest. 2009 Jan;119(1):136-45
pubmed: 19065049
Circ Res. 2022 Apr 29;130(9):1289-1305
pubmed: 35400205
Sci Transl Med. 2016 Apr 6;8(333):333ra50
pubmed: 27053774
Circulation. 2008 Oct 28;118(18):1837-47
pubmed: 18852364
Cell Death Differ. 2022 Jan;29(1):96-104
pubmed: 34304242
Sci Immunol. 2022 Apr 15;7(70):eabl7482
pubmed: 35427180
Circ Res. 2001 Apr 27;88(8):780-6
pubmed: 11325869
J Lipid Res. 2020 Mar;61(3):351-364
pubmed: 31988148
Immunity. 2018 Oct 16;49(4):595-613
pubmed: 30332628
Nat Rev Cardiol. 2019 Jul;16(7):389-406
pubmed: 30846875
Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1570-1578
pubmed: 28572160
Circ Res. 2020 May 8;126(10):e61-e79
pubmed: 32151196
J Am Heart Assoc. 2016 Aug 15;5(8):
pubmed: 27528409
Cell Metab. 2021 Dec 7;33(12):2445-2463.e8
pubmed: 34784501
Blood. 2010 Jan 21;115(3):e10-9
pubmed: 19965649
Eur Respir J. 2023 Mar 2;61(3):
pubmed: 36517180
Pharmacol Res. 2021 Mar;165:105447
pubmed: 33516832
Cardiovasc Res. 2018 Mar 15;114(4):590-600
pubmed: 29514202
Atherosclerosis. 2013 Jul;229(1):124-9
pubmed: 23578355
Circulation. 1967 Jul;36(1):1-4
pubmed: 6028742
Immunity. 2016 Mar 15;44(3):450-462
pubmed: 26982353
J Clin Invest. 2018 Mar 1;128(3):1106-1124
pubmed: 29457790
Pharmacol Ther. 2018 Aug;188:12-25
pubmed: 29444453
Cell Death Differ. 2022 Oct;29(10):2024-2033
pubmed: 35641782
Cell Death Differ. 2022 Jan;29(1):133-146
pubmed: 34363018
Circ Res. 2012 Aug 31;111(6):778-99
pubmed: 22935534
Circ Res. 2019 Dec 6;125(12):1087-1102
pubmed: 31625810
Nat Rev Cardiol. 2022 Jan;19(1):43-58
pubmed: 34267377
Circ J. 2016 Oct 25;80(11):2259-2268
pubmed: 27725526
Arterioscler Thromb Vasc Biol. 1999 Jan;19(1):98-105
pubmed: 9888871
J Pathol. 2020 Apr;250(5):705-714
pubmed: 32003464
Cardiovasc Diabetol. 2021 May 6;20(1):98
pubmed: 33957931
Nat Rev Mol Cell Biol. 2020 Jul;21(7):398-414
pubmed: 32251387
Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2081-5
pubmed: 8134352
Nat Cell Biol. 2014 Jan;16(1):55-65
pubmed: 24316671
Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1925-32
pubmed: 20651282
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):724-36
pubmed: 24558104
JCI Insight. 2019 Feb 21;4(4):
pubmed: 30830865
JCI Insight. 2020 Apr 9;5(7):
pubmed: 32191637
Front Cardiovasc Med. 2022 Apr 25;9:865367
pubmed: 35548412
Nat Immunol. 2020 Oct;21(10):1194-1204
pubmed: 32895539
Cell Death Differ. 2022 Jun;29(6):1199-1210
pubmed: 34974535
Nat Metab. 2022 Apr;4(4):444-457
pubmed: 35361955
Atherosclerosis. 2022 Apr;346:26-35
pubmed: 35255257
Cell. 2016 Oct 6;167(2):457-470.e13
pubmed: 27667687
Nat Immunol. 2015 Jul;16(7):689-97
pubmed: 26086143
Cell Death Differ. 2021 Sep;28(9):2728-2744
pubmed: 33934104
Nat Med. 2015 Jun;21(6):628-37
pubmed: 25985364
Circ Res. 2018 Oct 26;123(10):1127-1142
pubmed: 30359200
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):583-596
pubmed: 31996026