Design, synthesis and anticancer activity evaluation of 4-(3-1H-indazolyl)amino quinazoline derivatives as PAK4 inhibitors.
4-(3-1H-indazolyl)amino quinazoline derivatives
Anti-cancer
Apoptosis
Cell cycle arrest
PAK4 inhibitors
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 11 2023
15 11 2023
Historique:
received:
21
08
2023
revised:
08
10
2023
accepted:
11
10
2023
medline:
14
11
2023
pubmed:
22
10
2023
entrez:
21
10
2023
Statut:
ppublish
Résumé
A novel series of 4-(3-1H-indazolyl)amino quinazoline derivatives were developed as PAK4 inhibitors based on a scaffold hopping strategy. Compounds 27e, 27g, 27i and 27j were found to exhibit potent inhibitory activity against PAK4 (IC
Identifiants
pubmed: 37864885
pii: S0968-0896(23)00349-8
doi: 10.1016/j.bmc.2023.117501
pii:
doi:
Substances chimiques
Quinazolines
0
Protein Kinase Inhibitors
0
Antineoplastic Agents
0
Banques de données
ClinicalTrials.gov
['NCT02702492']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117501Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.