The Role of Ribosomal Proteins eL15 and eL36 in the Early Steps of Yeast 60S Ribosomal Subunit Assembly.
eL8-eL15-eL36 ribosomal protein cluster
ribosomal RNA domain I
ribosome
ribosome assembly
yeast
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
15 Dec 2023
15 Dec 2023
Historique:
received:
25
08
2023
revised:
16
10
2023
accepted:
16
10
2023
pubmed:
22
10
2023
medline:
22
10
2023
entrez:
21
10
2023
Statut:
ppublish
Résumé
Ribosomal proteins have important roles in maintaining the structure and function of mature ribosomes, but they also drive crucial rearrangement reactions during ribosome biogenesis. The contribution of most, but not all, ribosomal proteins to ribosome synthesis has been previously analyzed in the yeast Saccharomyces cerevisiae. Herein, we characterize the role of yeast eL15 during 60S ribosomal subunit formation. In vivo depletion of eL15 results in a shortage of 60S subunits and the appearance of half-mer polysomes. This is likely due to defective processing of the 27SA
Identifiants
pubmed: 37865285
pii: S0022-2836(23)00432-1
doi: 10.1016/j.jmb.2023.168321
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
168321Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.