Significance of SF3B1 Mutations in Myeloid Neoplasms.

Humans RNA Splicing Factors / genetics Prognosis Myelodysplastic Syndromes / diagnosis Mutation Neoplasms Phosphoproteins / genetics
Maematopoiesis Mutation Myeloid Neoplasm SF3B1 Tumor

Journal

Clinics in laboratory medicine
ISSN: 1557-9832
Titre abrégé: Clin Lab Med
Pays: United States
ID NLM: 8100174

Informations de publication

Date de publication:
12 2023
Historique:
medline: 1 11 2023
pubmed: 22 10 2023
entrez: 21 10 2023
Statut: ppublish

Résumé

Myelodysplastic neoplasm with low blasts and SF3B1 mutation (MDS-LB-SF3B1) has undergone significant classification changes in the past year with the publication of the 5th edition of the World Health Organization Classification of Tumors of Haematopoietic and Lymphoid Tissues and the International Consensus Classification. This article reviews the basic biology of SF3B1, iron metabolism, and dysfunction that leads to the formation of ring sideroblasts. It highlights neoplastic and non-neoplastic considerations to the differential diagnoses. Finally, a review on the evolution of the prognostic scoring system and treatment regimens that are available to patients with a diagnosis of MDS is presented.

Identifiants

DOI: 10.1016/j.cll.2023.07.005 PMID: 37865505
pubmed: 37865505
pii: S0272-2712(23)00077-X
doi: 10.1016/j.cll.2023.07.005
pii:
doi:

Substances chimiques

RNA Splicing Factors 0
SF3B1 protein, human 0
Phosphoproteins 0

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

597-606

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

David C Gajzer (DC)

University of Washington, Seattle, WA, USA.

Cecilia C S Yeung (CCS)

University of Washington, Seattle, WA, USA; Fred Hutch Cancer Center, Seattle, WA, USA. Electronic address: cyeung@fredhutch.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Significance of SF3B1 Mutations in Myeloid Neoplasms.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Facteurs d'épissage des ARN › Significance of SF3B1 Mutations in Myeloid Neoplasms.
questionsmedicales.fr › Diagnostic › Pronostic › Significance of SF3B1 Mutations in Myeloid Neoplasms.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myélodysplasiques › Significance of SF3B1 Mutations in Myeloid Neoplasms.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Significance of SF3B1 Mutations in Myeloid Neoplasms.
questionsmedicales.fr › Tumeurs › Significance of SF3B1 Mutations in Myeloid Neoplasms.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Significance of SF3B1 Mutations in Myeloid Neoplasms.