Health outcomes associated with phytosterols: An umbrella review of systematic reviews and meta-analyses of randomized controlled trials.

Humans Phytosterols Randomized Controlled Trials as Topic Systematic Reviews as Topic Cholesterol, LDL Outcome Assessment, Health Care
Health Lipid profile Metabolic syndrome Phytosterols Umbrella review

Journal

Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794

Informations de publication

Date de publication:
Jan 2024
Historique:
received: 09 06 2023
revised: 17 08 2023
accepted: 14 10 2023
medline: 14 11 2023
pubmed: 23 10 2023
entrez: 22 10 2023
Statut: ppublish

Résumé

Phytosterols (PS), as a kind of plant active ingredients, have many benefits to human health. However, there is currently no comprehensive overview of the clinical evidence and an assessment of the evidence quality. We conducted an umbrella review, which incorporated verification spanning a number of meta-analyses and systematic reviews to clarify the link that existed between PS consuming and health outcomes. The databases PubMed, Embase, Web of Science and The Cochrane Library were searched for appropriate research and ultimately included 23 articles involving 79 results. Methodological quality and the validity of evidence received designation in the included meta-analyses leveraging the Assessment of Multiple Systematic Reviews (AMSTAR-2) and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE). The consumption of PS makes a contribution to the alleviation of metabolic conditions such as hypercholesterolemia, diabetes, obesity, and hypertension. Its most essential function is to decrease cholesterol absorption, leading to dramatically reductions in total cholesterol and low density lipoprotein cholesterol. Furthermore, utilizing PS products can have a favorable impact on managing apolipoprotein levels along with decreasing the probability of obtaining atherosclerotic cardiovascular disease. This umbrella review summarized a range of beneficial functions of PS to humans, highlighting the promising potential for the development of PS into functional foods.

Sections du résumé

BACKGROUND BACKGROUND
Phytosterols (PS), as a kind of plant active ingredients, have many benefits to human health. However, there is currently no comprehensive overview of the clinical evidence and an assessment of the evidence quality.
PURPOSE OBJECTIVE
We conducted an umbrella review, which incorporated verification spanning a number of meta-analyses and systematic reviews to clarify the link that existed between PS consuming and health outcomes.
METHODS METHODS
The databases PubMed, Embase, Web of Science and The Cochrane Library were searched for appropriate research and ultimately included 23 articles involving 79 results. Methodological quality and the validity of evidence received designation in the included meta-analyses leveraging the Assessment of Multiple Systematic Reviews (AMSTAR-2) and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE).
RESULTS RESULTS
The consumption of PS makes a contribution to the alleviation of metabolic conditions such as hypercholesterolemia, diabetes, obesity, and hypertension. Its most essential function is to decrease cholesterol absorption, leading to dramatically reductions in total cholesterol and low density lipoprotein cholesterol. Furthermore, utilizing PS products can have a favorable impact on managing apolipoprotein levels along with decreasing the probability of obtaining atherosclerotic cardiovascular disease.
CONCLUSION CONCLUSIONS
This umbrella review summarized a range of beneficial functions of PS to humans, highlighting the promising potential for the development of PS into functional foods.

Identifiants

DOI: 10.1016/j.phymed.2023.155151 PMID: 37866333
pubmed: 37866333
pii: S0944-7113(23)00510-X
doi: 10.1016/j.phymed.2023.155151
pii:
doi:

Substances chimiques

Phytosterols 0
Cholesterol, LDL 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

155151

Informations de copyright

Copyright © 2023. Published by Elsevier GmbH.

Déclaration de conflit d'intérêts

Declaration of Competing Interest No conflicts of interest are declared by the authors.

Auteurs

Bing Liu (B)

College of Public Health, Zhengzhou University, Zhengzhou, China.

Ke Chen (K)

College of Public Health, Zhengzhou University, Zhengzhou, China.

Xi Chen (X)

College of Public Health, Zhengzhou University, Zhengzhou, China.

Jian Wang (J)

College of Public Health, Zhengzhou University, Zhengzhou, China.

Guangjie Shu (G)

College of Public Health, Zhengzhou University, Zhengzhou, China.

Zhiguang Ping (Z)

College of Public Health, Zhengzhou University, Zhengzhou, China.

Shenshen Zhang (S)

College of Public Health, Zhengzhou University, Zhengzhou, China; Food Laboratory of Zhongyuan, Luohe, China. Electronic address: zsslb2005@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Health outcomes associated with phytosterols:...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Phytostérols › Health outcomes associated with phytosterols:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Health outcomes associated with phytosterols:...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Moyens de communication › Publications › Littérature de revue comme sujet › Revues systématiques comme sujet › Health outcomes associated with phytosterols:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Health outcomes associated with phytosterols:...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Health outcomes associated with phytosterols:...