Unusual triterpenoids and steroids from Cipadessa baccifera and their biological activities.
Antibacterial
Antiproliferation
Cipadessa baccifera
Limonoid
Steroid
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
09
08
2023
revised:
18
10
2023
accepted:
19
10
2023
medline:
27
11
2023
pubmed:
23
10
2023
entrez:
22
10
2023
Statut:
ppublish
Résumé
Five undescribed triterpenoids and steroids (1-5), as well as ten known compounds, were purified from the branches and leaves of Cipadessa baccifera. Notably, 1 and 2 are rare cipadesin-type limonoids with an unusual 8,30-epoxide ring and 1,8-ether linkage, respectively. Compound 5 possessed pregnane steroid skeleton with an uncommon 5/6/6/6/5-fused ring system. Their structures were constructed by extensive spectroscopic analysis (NMR, IR, UV, and HRESIMS), and their absolute configurations were confirmed by ECD calculations and quantum chemical calculations. All the isolates were in vitro assayed for their antimicrobial potentials against 6 pathogenic microorganisms and antiproliferation activities against five human cancer cell lines. As a result, compounds 5, 12, 13, and 14 exhibited moderate antibacterial activities (MIC: 25-50 μg/mL). Moreover, 5 showed cytotoxicity against five cancer cell lines with IC
Identifiants
pubmed: 37866424
pii: S0367-326X(23)00283-6
doi: 10.1016/j.fitote.2023.105708
pii:
doi:
Substances chimiques
Triterpenes
0
Steroids
0
Limonins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105708Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.