Nano-Plumber Reshapes Glymphatic-Lymphatic System to Sustain Microenvironment Homeostasis and Improve Long-Term Prognosis after Traumatic Brain Injury.
brain homeostasis
drug delivery system
gene transfection
nanotechnology
tissue regeneration and repair
traumatic brain injury
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
24
08
2023
received:
27
06
2023
medline:
11
12
2023
pubmed:
23
10
2023
entrez:
22
10
2023
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Long-term changes in the microenvironment of the brain contribute to the degeneration of neurological function following TBI. However, current research focuses primarily on short-term modulation during the early phases of TBI, not on the critical significance of long-term homeostasis in the brain microenvironment. Notably, dysfunction of the glymphatic-lymphatic system results in the accumulation of danger/damage-associated molecular patterns (DAMPs) in the brain, which is regarded as the leading cause of long-term microenvironmental disturbances following TBI. Here, a nanostructure, Nano-plumber, that co-encapsulates the microenvironment regulator pro-DHA and the lymphatic-specific growth factor VEGF-C is developed, allowing for a sustainable and orderly regulation of the microenvironment to promote long-term neurological recovery. Nano-plumber reverses the injury microenvironment by suppressing microglia and astrocytes activation and maintaining reduced activation via enhanced glymphatic-lymphatic drainage, and significantly improves the neurological function of rodents with TBI. This study demonstrates that glymphatic-lymphatic system reconstruction is essential for enhancing long-term prognosis following TBI, and that the Nano-plumber developed here may serve as a clinically translatable treatment option for TBI.
Identifiants
pubmed: 37867233
doi: 10.1002/advs.202304284
pmc: PMC10700187
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2304284Subventions
Organisme : National Natural Science Foundation of China
ID : 82373814
Organisme : National Natural Science Foundation of China
ID : 92068110
Organisme : National Natural Science Foundation of China
ID : 92068111
Organisme : National Natural Science Foundation of China
ID : 81973272
Organisme : National Key Research and Development Program of China
ID : 2022YFC2502800
Organisme : Shanghai Science and Technology Committee
ID : 20JC1411800
Organisme : Shanghai Science and Technology Committee
ID : 23S41900100
Organisme : Shanghai Municipal Education Commission
ID : 2023ZKZD21
Organisme : Programs of Shanghai Academic/Technology Research Leader
ID : 21XD1400200
Organisme : Programs of Shanghai Academic/Technology Research Leader
ID : 21XD1422200
Informations de copyright
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
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