Global impact of proteoglycan science on human diseases.

Cancer Cellular physiology Neuroscience

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
17 Nov 2023
Historique:
medline: 23 10 2023
pubmed: 23 10 2023
entrez: 23 10 2023
Statut: epublish

Résumé

In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss the role of proteoglycans in selected and emerging areas of proteoglycan science, such as neurodegenerative diseases, autophagy, angiogenesis, cancer, infections and their impact on mammalian diseases.

Identifiants

pubmed: 37867945
doi: 10.1016/j.isci.2023.108095
pii: S2589-0042(23)02172-7
pmc: PMC10589900
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

108095

Informations de copyright

© 2023 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Christopher Xie (C)

Department of Pathology and Genomic Medicine, the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.

Liliana Schaefer (L)

Institute of Pharmacology and Toxicology, Goethe University, Frankfurt, Germany.

Renato V Iozzo (RV)

Department of Pathology and Genomic Medicine, the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.

Classifications MeSH