Pretrial predictors of conflict response efficacy in the human prefrontal cortex.
Biological sciences
Cognitive neuroscience
Neuroscience
Systems neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
received:
18
02
2022
revised:
14
07
2023
accepted:
21
09
2023
medline:
23
10
2023
pubmed:
23
10
2023
entrez:
23
10
2023
Statut:
epublish
Résumé
The ability to perform motor actions depends, in part, on the brain's initial state. We hypothesized that initial state dependence is a more general principle and applies to cognitive control. To test this idea, we examined human single units recorded from the dorsolateral prefrontal (dlPFC) cortex and dorsal anterior cingulate cortex (dACC) during a task that interleaves motor and perceptual conflict trials, the multisource interference task (MSIT). In both brain regions, variability in pre-trial firing rates predicted subsequent reaction time (RT) on conflict trials. In dlPFC, ensemble firing rate patterns suggested the existence of domain-specific initial states, while in dACC, firing patterns were more consistent with a domain-general initial state. The deployment of shared and independent factors that we observe for conflict resolution may allow for flexible and fast responses mediated by cognitive initial states. These results also support hypotheses that place dACC hierarchically earlier than dlPFC in proactive control.
Identifiants
pubmed: 37867949
doi: 10.1016/j.isci.2023.108047
pii: S2589-0042(23)02124-7
pmc: PMC10589857
doi:
Types de publication
Journal Article
Langues
eng
Pagination
108047Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
Dr. Sheth serves as a consultant for Boston Scientific, Zimmer Biomet, Neuropace, Koh Young, Varian Medical, Sensoria Therapeutics; and is a Co-founder of Motif Neurotech.
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