Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle.
BayesR
BayesRC
RNA splicing
complex traits
eQTL
gene expression
heritability
sQTL
Journal
Cell genomics
ISSN: 2666-979X
Titre abrégé: Cell Genom
Pays: United States
ID NLM: 9918284260106676
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
received:
08
06
2022
revised:
10
08
2022
accepted:
26
07
2023
medline:
23
10
2023
pubmed:
23
10
2023
entrez:
23
10
2023
Statut:
epublish
Résumé
Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) or RNA splicing (sVariants) are expected to significantly affect phenotypes. We quantify the contribution of eVariants and sVariants detected from 16 tissues (n = 4,725) to 37 traits of ∼120,000 cattle (average magnitude of genetic correlation between traits = 0.13). Analyzed in Bayesian mixture models, averaged across 37 traits,
Identifiants
pubmed: 37868035
doi: 10.1016/j.xgen.2023.100385
pii: S2666-979X(23)00182-9
pmc: PMC10589627
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100385Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Genet Sel Evol. 2020 Jul 7;52(1):37
pubmed: 32635893
Nat Commun. 2021 Nov 30;12(1):6972
pubmed: 34848700
Science. 2016 Apr 29;352(6285):600-4
pubmed: 27126046
Sci Rep. 2017 Aug 23;7(1):9248
pubmed: 28835686
PLoS Genet. 2015 Apr 07;11(4):e1004969
pubmed: 25849665
Nat Genet. 2022 Sep;54(9):1355-1363
pubmed: 35982161
Nat Commun. 2021 Feb 1;12(1):727
pubmed: 33526779
Nat Genet. 2017 Aug 30;49(9):1304-1310
pubmed: 28854176
J Allergy Clin Immunol. 2020 Apr;145(4):1208-1218
pubmed: 31707051
Nat Genet. 2021 Sep;53(9):1300-1310
pubmed: 34475573
Nat Genet. 2018 Mar;50(3):362-367
pubmed: 29459679
Nat Genet. 2021 Jul;53(7):949-954
pubmed: 34045765
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19398-19408
pubmed: 31501319
Front Genet. 2021 Jun 23;12:664379
pubmed: 34249087
BMC Genomics. 2016 Feb 27;17:144
pubmed: 26920147
Elife. 2022 Dec 14;11:
pubmed: 36515579
J Dairy Sci. 2012 Jul;95(7):4114-29
pubmed: 22720968
Commun Biol. 2022 Jul 5;5(1):661
pubmed: 35790806
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Nat Genet. 2012 Jul 22;44(8):955-9
pubmed: 22820512
Annu Rev Anim Biosci. 2019 Feb 15;7:89-102
pubmed: 30508490
Genome Biol. 2014;15(12):550
pubmed: 25516281
Genome Res. 2005 Aug;15(8):1034-50
pubmed: 16024819
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Nat Genet. 2012 Mar 18;44(4):369-75, S1-3
pubmed: 22426310
Nat Genet. 2020 Jun;52(6):626-633
pubmed: 32424349
Sci Rep. 2019 Feb 14;9(1):2137
pubmed: 30765736
PLoS Genet. 2014 May 15;10(5):e1004383
pubmed: 24830394
N Engl J Med. 2015 Sep 3;373(10):895-907
pubmed: 26287746
Science. 2020 Sep 11;369(6509):1318-1330
pubmed: 32913098
Commun Biol. 2021 Dec 2;4(1):1353
pubmed: 34857886
Nat Commun. 2021 Mar 23;12(1):1821
pubmed: 33758196
Nat Genet. 2018 Jan;50(1):151-158
pubmed: 29229983
Nature. 2022 Mar;603(7899):95-102
pubmed: 35197637
Am J Hum Genet. 2014 Nov 6;95(5):535-52
pubmed: 25439723
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 26;978-979:95-102
pubmed: 25531876
Nature. 2017 Oct 11;550(7675):204-213
pubmed: 29022597
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Nat Commun. 2019 Nov 8;10(1):5086
pubmed: 31704910
J Dairy Sci. 1995 Jan;78(1):205-20
pubmed: 7738256
Nat Genet. 2022 Sep;54(9):1438-1447
pubmed: 35953587
Bioinformatics. 2015 Mar 1;31(5):782-4
pubmed: 25338720
Cell. 2017 Jun 15;169(7):1177-1186
pubmed: 28622505
Nat Protoc. 2012 Feb 16;7(3):500-7
pubmed: 22343431
Nat Genet. 2015 Nov;47(11):1228-35
pubmed: 26414678
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Genome Biol. 2020 Nov 24;21(1):285
pubmed: 33234160
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nat Commun. 2022 May 9;13(1):2532
pubmed: 35534486
PLoS Genet. 2013 Jun;9(6):e1003491
pubmed: 23785294
Food Chem. 2017 Dec 15;237:865-869
pubmed: 28764079
Commun Biol. 2020 Feb 28;3(1):88
pubmed: 32111961
Bioinformatics. 2016 May 15;32(10):1479-85
pubmed: 26708335
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5
pubmed: 12883005
Nat Genet. 2014 Aug;46(8):858-65
pubmed: 25017103
BMC Biol. 2020 Jul 3;18(1):80
pubmed: 32620158
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
Nat Commun. 2021 Feb 8;12(1):860
pubmed: 33558518
Gigascience. 2020 Mar 1;9(3):
pubmed: 32191811
BMC Genomics. 2018 Jul 4;19(1):521
pubmed: 29973141
Nat Commun. 2014 Aug 07;5:4398
pubmed: 25099282