Relationship between BDNF and oxytocin.
Biomarkers
Brain-derived neurotrophic factor
Humans plasma
Interactions
Oxytocin
Platelets
Journal
Comprehensive psychoneuroendocrinology
ISSN: 2666-4976
Titre abrégé: Compr Psychoneuroendocrinol
Pays: England
ID NLM: 101774169
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
10
07
2023
revised:
29
08
2023
accepted:
01
09
2023
medline:
23
10
2023
pubmed:
23
10
2023
entrez:
23
10
2023
Statut:
epublish
Résumé
Converging, albeit scattered data mainly gathered in animals indicate that the neurotrophin brain-derived neurotrophic factor (BDNF) and the nonapeptide oxytocin (OT) interact in a cooperative way. Data in humans are really limited and indirect. Therefore, the aim of the present study was to explore the possible existence of a link between OT and BDNF in humans, by means of two peripheral markers, the platelet-poor-plasmatic-BDNF (PPP-BDNF) and the platelet BDNF (PLT-BDNF) and OT levels. Twenty-six young healthy controls of both sexes who volunteered for the study were included in the study. Fifty ml of peripheral venous blood were drawn from one-night fasting subjects between 8.00 and 9.00 a.m. The BDNF and OT assays were carried out according to common methods. Comparisons for continuous variables were performed by the Student's t-test for variables that follow a normal distribution, and by the Wilcoxon-Mann-Whitney test for variables not normally distributed. The correlations between biological markers were explored by calculating the Pearson's correlation coefficient or Spearman's rank correlation. The results showed that PLT-BDNF (pg/mg proteins, mean ± SD) and PPP-BDNF (pg/ml, mean ± SD) were 1546 ± 1844 and 10111 ± 1892, respectively. The OT levels (pg/ml, mean ± SD) were 13.92 ± 4.54. The OT levels were significantly higher in women than in men. The Spearman's analysis revealed a statistically significant and negative correlation between OT levels and PLT-BDNF (R = -0.543, p = 0.004). The findings of this study highlight the presence of a significant and negative correlation between OT and PLT-BDNF in a small group of healthy controls of both sexes. In any case, despite all the limits of peripheral biomarkers, they suggest that this reciprocal influence might have a downstream homeostatic function dampening one activity when the other is activated or no longer necessary, maybe at the level of the stress and/or immune systems.
Identifiants
pubmed: 37868112
doi: 10.1016/j.cpnec.2023.100207
pii: S2666-4976(23)00041-3
pmc: PMC10585630
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100207Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
None.
Références
Stroke. 2011 Dec;42(12):3606-11
pubmed: 21960564
J Endocrinol. 1997 Aug;154(2):347-53
pubmed: 9291845
Nat Neurosci. 2023 Jun;26(6):1032-1041
pubmed: 37280397
J Neurosci Res. 2015 Jun;93(6):893-901
pubmed: 25612898
J Neuroendocrinol. 2004 Apr;16(4):319-24
pubmed: 15089969
Stress. 2015;18(4):451-61
pubmed: 26061800
Curr Opin Neurobiol. 2004 Dec;14(6):777-83
pubmed: 15582383
Neurobiol Aging. 2005 Jan;26(1):115-23
pubmed: 15585351
Neuropeptides. 2014 Oct;48(5):281-6
pubmed: 25047873
Front Genet. 2015 Jun 30;6:230
pubmed: 26175754
Neurol Sci. 2021 May;42(5):1861-1867
pubmed: 32940801
Mol Neurobiol. 2020 Jan;57(1):290-301
pubmed: 31327126
Psychoneuroendocrinology. 2018 Mar;89:131-133
pubmed: 29414026
Thromb Haemost. 2002 Apr;87(4):728-34
pubmed: 12008958
Psychosom Med. 2006 Mar-Apr;68(2):238-45
pubmed: 16554389
Glia. 2019 Feb;67(2):345-359
pubmed: 30506969
Neuropharmacology. 2014 Jan;76 Pt C:610-27
pubmed: 23791959
Histol Histopathol. 2010 Feb;25(2):237-58
pubmed: 20017110
Sci Rep. 2017 Jul 31;7(1):6871
pubmed: 28761093
Clin Pract Epidemiol Ment Health. 2019 Mar 26;15:58-63
pubmed: 31015856
Neuron. 2012 Feb 9;73(3):553-66
pubmed: 22325206
Med Sci Monit. 2015 Jan 06;21:69-75
pubmed: 25559382
Nat Neurosci. 2004 Oct;7(10):1048-54
pubmed: 15452576
Clin Neuropsychiatry. 2020 Jun;17(3):195
pubmed: 34908994
Physiol Behav. 1996 Nov;60(5):1209-15
pubmed: 8916173
Front Psychiatry. 2021 Feb 22;12:633664
pubmed: 33692712
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
Cell Mol Neurobiol. 2012 Jul;32(5):891-6
pubmed: 22252786
Arch Med Sci. 2015 Dec 10;11(6):1164-78
pubmed: 26788077
Psychoneuroendocrinology. 2007 May;32(4):407-10
pubmed: 17383107
Psychoneuroendocrinology. 2019 May;103:276-283
pubmed: 30771710
Acta Pharmacol Sin. 2011 Jan;32(1):3-11
pubmed: 21131999
J Neurosci. 2022 Nov 9;42(45):8439-8449
pubmed: 36351821
Mol Psychiatry. 2014 Jul;19(7):791-800
pubmed: 23958957
Neuromolecular Med. 2020 Dec;22(4):557-571
pubmed: 32918238
Neuropsychobiology. 2010;62(4):207-12
pubmed: 20714169
Psychoneuroendocrinology. 2011 Feb;36(2):228-39
pubmed: 20702043
Elife. 2018 Sep 07;7:
pubmed: 30192229
Front Psychiatry. 2020 Feb 28;10:1032
pubmed: 32184739
Clin Pract Epidemiol Ment Health. 2006 Oct 11;2:28
pubmed: 17034623
Lancet Diabetes Endocrinol. 2023 Jul;11(7):454-464
pubmed: 37192642
Neuropharmacology. 2014 Jan;76 Pt C:601-2
pubmed: 23973290
Z Psychosom Med Psychother. 2005;51(1):57-80
pubmed: 15834840
Transl Psychiatry. 2016 Nov 22;6(11):e958
pubmed: 27874848
Nat Rev Neurosci. 2013 Jan;14(1):7-23
pubmed: 23254191
J Endocrinol. 1973 Jun;57(3):477-93
pubmed: 4577217
Transl Psychiatry. 2012 Aug 14;2:e150
pubmed: 22892716
Curr Med Chem. 2008;15(7):698-704
pubmed: 18336283
Psychodyn Psychiatry. 2017 Winter;45(4):499-517
pubmed: 29244625
J Neurodev Disord. 2009 Sep;1(3):215-23
pubmed: 21547716
Int J Neuropsychopharmacol. 2011 Apr;14(3):347-53
pubmed: 20604989
J Mol Neurosci. 2013 Jul;50(3):462-8
pubmed: 23335033
Mol Neurobiol. 2019 May;56(5):3295-3312
pubmed: 30117106
Neuropsychopharmacology. 2005 Feb;30(2):223-30
pubmed: 15536493
Am J Pathol. 1999 Oct;155(4):1183-93
pubmed: 10514401
Am J Physiol Endocrinol Metab. 2017 Mar 1;312(3):E183-E189
pubmed: 28049625
Pharmacol Rev. 2012 Apr;64(2):238-58
pubmed: 22407616
J Mol Neurosci. 2021 Oct;71(10):2008-2021
pubmed: 33230708
Brain Res. 1996 Feb 12;709(1):122-301
pubmed: 8869564
Biol Psychiatry. 2010 Mar 15;67(6):e33-4; author reply e35
pubmed: 20060102
Eur Neuropsychopharmacol. 2012 Aug;22(8):578-83
pubmed: 22297159
Biotech Histochem. 2019 Oct;94(7):469-480
pubmed: 31104534
J Affect Disord. 2022 Jun 1;306:167-173
pubmed: 35314247