Refined control of CRISPR-Cas9 gene editing in
CRISPR-Cas9
Clostridium sporogenes
cancer
cytokines
immunotherapy
secretion
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
06
2023
accepted:
01
09
2023
medline:
2
11
2023
pubmed:
23
10
2023
entrez:
23
10
2023
Statut:
epublish
Résumé
Despite considerable clinical success, the potential of cancer immunotherapy is restricted by a lack of tumour-targeting strategies. Treatment requires systemic delivery of cytokines or antibodies at high levels to achieve clinically effective doses at malignant sites. This is exacerbated by poor penetration of tumour tissue by therapeutic antibodies. High-grade immune-related adverse events (irAEs) occur in a significant number of patients (5-15%, cancer- and therapeutic-dependent) that can lead to lifelong issues and can exclude from treatment patients with pre-existing autoimmune diseases. Tumour-homing bacteria, genetically engineered to produce therapeutics, is one of the approaches that seeks to mitigate these drawbacks. The ability of
Identifiants
pubmed: 37869009
doi: 10.3389/fimmu.2023.1241632
pmc: PMC10585264
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1241632Informations de copyright
Copyright © 2023 Kubiak, Claessen, Zhang, Khazaie and Bailey.
Déclaration de conflit d'intérêts
AK was an employee of Exomnis Biotech B.V. at the time of the study design and execution. AK is an inventor on two patents pending WO2021123391 and WO2022171904. TB is an inventor on one patent pending WO2022171904. LC was an employee of Exomnis Biotech B.V. at the time of the study design and execution 2021/2022. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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