Life-course adiposity and severe liver disease: a Mendelian randomization analysis.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
21
07
2023
received:
29
04
2023
accepted:
04
08
2023
medline:
27
11
2023
pubmed:
23
10
2023
entrez:
23
10
2023
Statut:
ppublish
Résumé
There is little evidence on the genetic associations between life-course adiposity (including birth weight, childhood BMI, and adulthood BMI) and severe liver disease (SLD; including cirrhosis and liver cancer). The current study aimed to examine and contrast these associations. Genetic variants were obtained from genome-wide association studies. Two-sample Mendelian randomization (MR) analyses were performed to assess the genetic associations of life-course adiposity with SLD and liver biomarkers. Cox regression was used to estimate adjusted hazard ratios for SLD associated with genetic risk scores of life-course adiposity and adulthood weight change in the China Kadoorie Biobank. In observational analyses, genetic predispositions to childhood adiposity and adulthood adiposity were each associated with SLD. There was a U-shaped association between adulthood weight change and risk of SLD. In meta-analyses of MR results, genetically predicted 1-standard deviation increase in birth weight was inversely associated with SLD at a marginal significance (odds ratio: 0.81 [95% CI: 0.65-1.00]), whereas genetically predicted 1-standard deviation higher childhood BMI and adulthood BMI were positively associated with SLD (odds ratio: 1.27 [95% CI: 1.05-1.55] and 1.79 [95% CI: 1.59-2.01], respectively). The results of liver biomarkers mirrored those of SLD. The current study provided genetic evidence on the associations between life-course adiposity and SLD.
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3077-3085Subventions
Organisme : China Postdoctoral Science Foundation
ID : 2019TQ0008
Organisme : China Postdoctoral Science Foundation
ID : 2020M670071
Organisme : Kadoorie Charitable Foundation
Organisme : Ministry of Science and Technology of the People's Republic of China
ID : 2011BAI09B01
Organisme : National Key Research and Development Program of China
ID : 2016YFC0900500
Organisme : National Natural Science Foundation of China
ID : 81390540
Organisme : National Natural Science Foundation of China
ID : 81941018
Organisme : National Natural Science Foundation of China
ID : 82192900
Organisme : National Natural Science Foundation of China
ID : 82192901
Organisme : National Natural Science Foundation of China
ID : 82192904
Organisme : National Natural Science Foundation of China
ID : 91846303
Organisme : National Natural Science Foundation of China
ID : 82304223
Organisme : Peking University Medicine Fund of Fostering Young Scholars' Scientific & Technological Innovation
ID : BMU2022RCZX022
Organisme : UK Wellcome Trust
ID : 088158/Z/09/Z
Organisme : UK Wellcome Trust
ID : 104085/Z/14/Z
Organisme : UK Wellcome Trust
ID : 202922/Z/16/Z
Organisme : UK Wellcome Trust
ID : 212946/Z/18/Z
Informations de copyright
© 2023 The Obesity Society.
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