Toward a Nanoencapsulated EPR Imaging Agent for Clinical Use.
EPR imaging
Electron paramagnetic resonance (EPR)
Encapsulated
Imaging agent
RADI-Sense
Radiotherapy guidance
pO2
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
23 Oct 2023
23 Oct 2023
Historique:
received:
01
05
2023
accepted:
25
09
2023
revised:
21
09
2023
medline:
23
10
2023
pubmed:
23
10
2023
entrez:
23
10
2023
Statut:
aheadofprint
Résumé
Progress toward developing a novel radiocontrast agent for determining pO The imaging agent is based on a nanoscaffold of aluminum hydroxide (boehmite) with sizes from 100 to 200 nm, paramagnetic probe molecule, and encapsulation with a gas permeable, thin (10-20 nm) polymer layer to separate the imaging agent and body environment while still allowing O Side-by-side in vivo imaging comparisons made in a mouse model made between RADI-Sense and free paramagnetic probe (OX-071) showed oxygen sensitivity is retained and RADI-Sense can create 3D pO
Identifiants
pubmed: 37870648
doi: 10.1007/s11307-023-01863-0
pii: 10.1007/s11307-023-01863-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : 75N91010C00032
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to World Molecular Imaging Society.
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