The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione (ISOAC1) as a new molecule able to inhibit Amyloid β aggregation and neurotoxicity.

Humans Alzheimer Disease / metabolism Amyloid beta-Peptides Pentanes / pharmacology Peptide Fragments / toxicity Protein Aggregates
Alzheimer’s disease Amyloid β 1–42 aggregation Neuroprotection β-diketone-3-substituted isoindolinone

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 23 08 2023
revised: 12 10 2023
accepted: 16 10 2023
medline: 15 11 2023
pubmed: 24 10 2023
entrez: 23 10 2023
Statut: ppublish

Résumé

Amyloid β 1-42 (Aβ

Identifiants

DOI: 10.1016/j.biopha.2023.115745 PMID: 37871561
pubmed: 37871561
pii: S0753-3322(23)01543-3
doi: 10.1016/j.biopha.2023.115745
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
pentane 4FEX897A91
Pentanes 0
Peptide Fragments 0
Protein Aggregates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115745

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that there are no conflicts of interests.

Auteurs

Ilaria Piccialli (I)

Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Naples, Italy.

Francesca Greco (F)

Department of Pharmacy, Federico II University of Naples, Naples, Italy.

Giovanni Roviello (G)

Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Naples, Italy.

Maria Josè Sisalli (MJ)

Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Naples, Italy.

Valentina Tedeschi (V)

Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Naples, Italy.

Antonia di Mola (A)

Department of Chemistry and Biology "A. Zambelli", University of Salerno, Fisciano, SA, Italy.

Nicola Borbone (N)

Department of Pharmacy, Federico II University of Naples, Naples, Italy.

Giorgia Oliviero (G)

Department of Molecular Medicine and Medical Biotechnologies, Federico II University of Naples, Naples, Italy.

Vincenzo De Feo (V)

Department of Pharmacy, University of Salerno, Fisciano, SA, Italy.

Agnese Secondo (A)

Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Naples, Italy.

Antonio Massa (A)

Department of Chemistry and Biology "A. Zambelli", University of Salerno, Fisciano, SA, Italy. Electronic address: amassa@unisa.it.

Anna Pannaccione (A)

Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Naples, Italy. Electronic address: pannacio@unina.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Pentanes › The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione...
questionsmedicales.fr › Structures macromoléculaires › Agrégats de protéines › The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione...