Effect of F11 Receptor/Junctional Adhesion Molecule-A-derived Peptide on Neointimal Hyperplasia in a Murine Model.
Journal
Journal of vascular and interventional radiology : JVIR
ISSN: 1535-7732
Titre abrégé: J Vasc Interv Radiol
Pays: United States
ID NLM: 9203369
Informations de publication
Date de publication:
21 Oct 2023
21 Oct 2023
Historique:
received:
02
03
2023
revised:
24
09
2023
accepted:
15
10
2023
pubmed:
24
10
2023
medline:
24
10
2023
entrez:
23
10
2023
Statut:
aheadofprint
Résumé
To determine whether inhibition of the F11 receptor/JAM-A (F11R) using F11R-specific antagonist peptide 4D results in inhibition of smooth muscle cell (SMC) proliferation and migration in vivo, known as neointimal hyperplasia (NIH), using a mouse focal carotid artery stenosis model (FCASM). The mouse FCASM was chosen to test the hypothesis because the dominant cell type at the site of stenosis is SMC, similar to that in vascular access stenosis. Fourteen C57BL/6 mice underwent left carotid artery (LCA) partial ligation to induce stenosis, followed by daily injection of peptide 4D in 7 mice and saline in the remaining 7 mice, and these mice were observed for 21 days and then euthanized. Bilateral carotid arteries were excised for histologic analysis of the intima and media areas. The mean intimal area was significantly larger in control mice compared with peptide 4D-treated mice (0.031 mm Peptide 4D, an F11R antagonist, significantly inhibited NIH in C57BL/6 mice in a FCASM.
Identifiants
pubmed: 37871832
pii: S1051-0443(23)00755-8
doi: 10.1016/j.jvir.2023.10.012
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 SIR. Published by Elsevier Inc. All rights reserved.